Nature Search

Mosaic anatomy in an early fossil squamate

Breugnathair elgolensis gen. et sp. nov., an early squamate identified from a newly discovered Middle Jurassic skeleton on the Isle of Skye, provides new evidence on the origins of snakes.

Roger B. J. Benson
Stig A. Walsh
Susan E. Evans
ResearchOpen Access01 Oct 2025
Nature

P: 1-7
Disruption of the oak tree microbiome with urbanization

Urbanization disrupts oak tree microbiomes by reducing beneficial fungi and increasing plant and human pathogens across leaves, roots and soils, with consequences for tree health, urban climate mitigation and potential human exposure to pathogens.

Kathryn F. Atherton
Chikae Tatsumi
Jennifer M. Bhatnagar
Research03 Oct 2025
Nature Cities

P: 1-11
Correlates of risk of respiratory syncytial virus disease: a prospective cohort study

This study found higher RSV antibody levels were associated with lower RSV risk in children outside the hospital. An earlier rise in incidence and higher incidence rates were observed among children <5 years compared to older children and adults.

Collrane Frivold
Sarah N. Cox
Helen Y. Chu
ResearchOpen Access26 Sept 2025
Nature Communications

Volume: 16, P: 1-12
Remote sensing for healthy vegetation on green roofs

Green roofs enhance urban ecosystem services, but the long-term vegetation health and design’s impact is underexplored. This study shows a temporal increase in vegetation health and identifies key factors and thresholds that support sustained vegetation health, offering guidance for effective green roof planning and design.

Wenxi Liao
Madison Appleby
Sean C. Thomas
Research08 Oct 2025
Nature Cities

P: 1-10
Polygenic and developmental profiles of autism differ by age at diagnosis

A study of several longitudinal birth cohorts and cross-sectional cohorts finds only moderate overlap in genetic variants between autism that is diagnosed earlier and that diagnosed later, so they may represent aetiologically different conditions.

Xinhe Zhang
Jakob Grove
Varun Warrier
ResearchOpen Access01 Oct 2025
Nature

P: 1-12
Polygenic prediction of body mass index and obesity through the life course and across ancestries

Polygenic scores for body mass index and obesity constructed using data from 5 million people with different ancestries were associated with distinct weight gain trajectories from early childhood to adulthood.

Roelof A. J. Smit
Kaitlin H. Wade
Ruth J. F. Loos
ResearchOpen Access21 Jul 2025
Nature Medicine

Volume: 31, P: 3151-3168
Targeting histone H2B acetylated enhanceosomes via p300/CBP degradation in prostate cancer

This study shows that p300/CBP-dependent H2B acetylation is crucial for maintaining transcription of oncogenic gene programs in androgen receptor-driven prostate cancer.

Jie Luo
Zhixiang Chen
Arul M. Chinnaiyan
ResearchOpen Access03 Oct 2025
Nature Genetics

P: 1-14
Association of genetic scores related to insulin resistance with neurological outcomes in ancestrally diverse cohorts from the Trans-Omics for Precision Medicine (TOPMed) program

Polygenic scores and partitioned polygenic scores related to insulin resistance derived in multiancestry populations show distinct association with neurological outcomes

Chloé Sarnowski
Yixin Zhang
David C. Glahn
ResearchOpen Access24 Sept 2025
Communications Biology

Volume: 8, P: 1-11
Genome-wide association meta-analysis of childhood ADHD symptoms and diagnosis identifies new loci and potential effector genes

Genome-wide association meta-analyses of attention-deficit/hyperactivity disorder symptom measures and clinical diagnoses identify new risk loci, highlight putative effector genes and yield improved polygenic risk scores.

Camiel M. van der Laan
Hill F. Ip
Dorret I. Boomsma
Research17 Sept 2025
Nature Genetics

P: 1-9
Hominin glacial-stage occupation 712,000 to 424,000 years ago at Fordwich Pit, Old Park (Canterbury, UK)

The authors report Acheulean hominin occupation of eastern Britain during glacial marine isotope stages 17–16 and again in glacial marine isotope stage 12 via stone tools in sediments dated to 712,000 to 424,000 years ago.

Alastair Key
James Clark
Tomos Proffitt
ResearchOpen Access01 Sept 2025
Nature Ecology & Evolution

Volume: 9, P: 1781-1790
GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
ResearchOpen Access17 May 2023
Nature

Volume: 617, P: 764-768
Joint, multifaceted genomic analysis enables diagnosis of diverse, ultra-rare monogenic presentations

Using well-calibrated statistical methods the authors jointly analyze Undiagnosed Diseases Network genomes, identifying known and novel disease genes. Software is publicly available to support future cross-cohort rare disease discovery efforts.

Shilpa Nadimpalli Kobren
Mikhail A. Moldovan
Shamil R. Sunyaev
ResearchOpen Access07 Aug 2025
Nature Communications

Volume: 16, P: 1-19
DNA methylation cooperates with genomic alterations during non-small cell lung cancer evolution

Integrated multi-omic analyses using samples from the TRACERx study highlight cross-talk between DNA hypermethylation and genomic lesions in non-small cell lung cancer.

Francisco Gimeno-Valiente
Carla Castignani
Nnennaya Kanu
ResearchOpen Access10 Sept 2025
Nature Genetics

Volume: 57, P: 2226-2237
Publisher Correction: Genome-wide association meta-analysis of childhood ADHD symptoms and diagnosis identifies new loci and potential effector genes

Camiel M. van der Laan
Hill F. Ip
Dorret I. Boomsma
Amendments and Corrections29 Sept 2025
Nature Genetics

P: 1
Cross-Product Extensions of the Gene Ontology

Christopher Mungall
Michael Bada
Jane Lomax
ResearchOpen Access29 Jul 2009
Nature Precedings

P: 1
A statistical framework for multi-trait rare variant analysis in large-scale whole-genome sequencing studies

MultiSTAAR provides a general and flexible statistical framework for functionally informed multi-trait rare variant analysis of biobank-scale sequencing studies by jointly analyzing multiple traits and incorporating annotation information.

Xihao Li
Han Chen
Xihong Lin
Research07 Feb 2025
Nature Computational Science

Volume: 5, P: 125-143
Sequencing in over 50,000 cases identifies coding and structural variation underlying atrial fibrillation risk

Analyses of genome and exome sequencing data identify rare coding and structural variants associated with atrial fibrillation and highlight genetic links between atrial fibrillation and cardiomyopathies.

Seung Hoan Choi
Sean J. Jurgens
Patrick T. Ellinor
Research06 Mar 2025
Nature Genetics

Volume: 57, P: 548-562
Group-Translocation: A Consequence of Enzyme-Catalysed Group-Transfer

PETER MITCHELL
JENNIFER MOYLE
Research09 Aug 1958
Nature

Volume: 182, P: 372-373
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Structure of Vitamin B₁₂

DOROTHY CROWFOOT HODGKIN
JENNIFER KAMPER
JOHN G. WHITE
Research14 Jul 1956
Nature

Volume: 178, P: 64-66
Erratum: DNA-modified nanocrystalline diamond thin-films as stable, biologically active substrates

Wensha Yang
Orlando Auciello
Robert J. Hamers
Amendments and Corrections01 Jan 2003
Nature Materials

Volume: 2, P: 63
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Whole genome sequencing analysis of body mass index identifies novel African ancestry-specific risk allele

Here, the authors leverage whole-genome sequencing from >88,000 diverse individuals to uncover 18 BMI-related genetic signals, including novel variants in participants of African genetic ancestry, highlighting the value of diversity in genetic discovery.

Xinruo Zhang
Jennifer A. Brody
Anne E. Justice
ResearchOpen Access11 Apr 2025
Nature Communications

Volume: 16, P: 1-15
Tegavivint triggers TECR-dependent nonapoptotic cancer cell death

In chemical-genetic and lipidomics analyses, the clinical candidate oncology drug tegavivint induced an unconventional form of nonapoptotic cell death that required the lipid metabolic enzyme trans-2,3-enoyl-CoA reductase.

Logan Leak
Ziwei Wang
Scott J. Dixon
Research26 May 2025
Nature Chemical Biology

P: 1-12
Aberrant activation of TCL1A promotes stem cell expansion in clonal haematopoiesis

Using data from a single time point, passenger-approximated clonal expansion rate (PACER) estimates the fitness of common driver mutations that lead to clonal haematopoiesis and identifies TCL1A activation as a mediator of clonal expansion.

Joshua S. Weinstock
Jayakrishnan Gopakumar
Siddhartha Jaiswal
Research12 Apr 2023
Nature

Volume: 616, P: 755-763
Changing the identity of a transfer RNA

Jennifer Normanly
Richard C. Ogden
John Abelson
Research15 May 1986
Nature

Volume: 321, P: 213-219
Occurrence of a Phosphoric Ester in Certain Bacteria: Its Relation to Gram Staining and Penicillin Sensitivity

PETER MITCHELL
JENNIFER MOYLE
Research05 Aug 1950
Nature

Volume: 166, P: 218-220
Correction: Corrigendum: DICER1 and microRNA regulation in post-traumatic stress disorder with comorbid depression

Aliza P. Wingo
Lynn M. Almli
Kerry J. Ressler
Amendments and CorrectionsOpen Access03 Mar 2016
Nature Communications

Volume: 7, P: 1
Whole-genome sequencing reveals host factors underlying critical COVID-19

Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

Athanasios Kousathanas
Erola Pairo-Castineira
J. Kenneth Baillie
ResearchOpen Access07 Mar 2022
Nature

Volume: 607, P: 97-103
A saturated map of common genetic variants associated with human height

A large genome-wide association study of more than 5 million individuals reveals that 12,111 single-nucleotide polymorphisms account for nearly all the heritability of height attributable to common genetic variants.

Loïc Yengo
Sailaja Vedantam
Joel N. Hirschhorn
ResearchOpen Access12 Oct 2022
Nature

Volume: 610, P: 704-712
Accumulation of Neural Activity in the Posterior Insula Encodes the Passage of Time

Marc Wittmann
Alan Simmons
Martin Paulus
ResearchOpen Access10 Jul 2008
Nature Precedings

P: 1
Structure–based rescue of common tumor–derived p53 mutants

Ania M. Wieczorek
Jennifer L.F. Waterman
Thanos D. Halazonetis
Research01 Oct 1996
Nature Medicine

Volume: 2, P: 1143-1146
Cancer-induced nerve injury promotes resistance to anti-PD-1 therapy

Perineural invasion and cancer-induced nerve injury of tumour-associated nerves are associated with poor response to anti-PD-1 therapy, which can be reversed by combining anti-PD-1 therapy with anti-inflammatory interventions.

Erez N. Baruch
Frederico O. Gleber-Netto
Moran Amit
ResearchOpen Access20 Aug 2025
Nature

Volume: 646, P: 462-473
Sequence diversity lost in early pregnancy

Around 1 in 136 pregnancies is lost due to a pathogenic small sequence variant genotype in the fetus.

Gudny A. Arnadottir
Hakon Jonsson
Kari Stefansson
ResearchOpen Access21 May 2025
Nature

Volume: 642, P: 672-681
A framework for detecting noncoding rare-variant associations of large-scale whole-genome sequencing studies

STAARpipeline is a comprehensive framework for flexible and scalable rare-variant association analysis using whole-genome sequencing data and annotation information.

Zilin Li
Xihao Li
Xihong Lin
Research27 Oct 2022
Nature Methods

Volume: 19, P: 1599-1611
SARS-CoV-2 evolution during treatment of chronic infection

Chronic infection with SARS-CoV-2 leads to the emergence of viral variants that show reduced susceptibility to neutralizing antibodies in an immunosuppressed individual treated with convalescent plasma.

Steven A. Kemp
Dami A. Collier
Ravindra K. Gupta
Research05 Feb 2021
Nature

Volume: 592, P: 277-282
Predicting opioid consumption after surgical discharge: a multinational derivation and validation study using a foundation model

Chris Varghese
Luke Peters
Caroline Reinke
ResearchOpen Access26 Aug 2025
npj Digital Medicine

Volume: 8, P: 1-16
A generic non-invasive neuromotor interface for human-computer interaction

A high-bandwidth neuromotor interface offers performant out-of-the-box generalization across people.

Patrick Kaifosh
Thomas R. Reardon
Danny Zlobinsky
ResearchOpen Access23 Jul 2025
Nature

Volume: 645, P: 702-711
Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies

Sera from vaccinated individuals and some monoclonal antibodies show a modest reduction in neutralizing activity against the B.1.1.7 variant of SARS-CoV-2; but the E484K substitution leads to a considerable loss of neutralizing activity.

Dami A. Collier
Anna De Marco
Ravindra K. Gupta
Research11 Mar 2021
Nature

Volume: 593, P: 136-141
Self-administered mindfulness interventions reduce stress in a large, randomized controlled multi-site study

Does self-administered mindfulness effectively reduce stress? In a study across 37 sites involving 2,239 participants, four mindfulness exercises significantly reduced short-term, self-reported stress.

Alessandro Sparacio
Hans IJzerman
Gabriela M. Jiga-Boy
ResearchOpen Access11 Jun 2024
Nature Human Behaviour

Volume: 8, P: 1716-1725
Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals

Meta-analyses in up to 1.3 million individuals identify 87 rare-variant associations with blood pressure traits. On average, rare variants exhibit effects ~8 times larger than the mean effects of common variants and implicate candidate causal genes at associated regions.

Praveen Surendran
Elena V. Feofanova
Joanna M. M. Howson
Research23 Nov 2020
Nature Genetics

Volume: 52, P: 1314-1332
Acid Phosphatases

C. A. VERNON
J. GAULDIE
BARBARA E. C. BANKS
Research23 Oct 1965
Nature

Volume: 208, P: 382-383
Meta-analysis of exome-wide gene burden analysis of breast cancer susceptibility genes

Jennifer A. Collister
Karl Smith-Byrne
David J. Hunter
ResearchOpen Access03 Oct 2025
npj Breast Cancer

Volume: 11, P: 1-6
Whole-genome sequencing of 490,640 UK Biobank participants

A study reports whole-genome sequences for 490,640 participants from the UK Biobank and combines these data with phenotypic data to provide new insights into the relationship between human variation and sequence variation.

Keren Carss
Bjarni V. Halldorsson
Ole Schulz-Trieglaff
ResearchOpen Access06 Aug 2025
Nature

Volume: 645, P: 692-701
Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility

Both rare and common variants contribute to the aetiology of complex traits such as type 2 diabetes (T2D). Here, the authors examine the effect of coding variation on glycaemic traits and T2D, and identify low-frequency variation in GLP1Rsignificantly associated with these traits.

Jennifer Wessel
Audrey Y Chu
Mark O Goodarzi
ResearchOpen Access29 Jan 2015
Nature Communications

Volume: 6, P: 1-16
The power of genetic diversity in genome-wide association studies of lipids

A genome-wide association meta-analysis study of blood lipid levels in roughly 1.6 million individuals demonstrates the gain of power attained when diverse ancestries are included to improve fine-mapping and polygenic score generation, with gains in locus discovery related to sample size.

Sarah E. Graham
Shoa L. Clarke
Cristen J. Willer
Research09 Dec 2021
Nature

Volume: 600, P: 675-679
Gene Curation Software at the Rat Genome Database (RGD)

Shur-Jen Wang
George Kowalski
G. Thomas Hayman
ResearchOpen Access20 Oct 2010
Nature Precedings

P: 1
Genetic analysis of autoimmune type 1 diabetes mellitus in mice

John A. Todd
Timothy J. Aitman
Linda S. Wicker
Research13 Jun 1991
Nature

Volume: 351, P: 542-547
Cloning and analysis of cDNAs encoding plant storage protein precursors

Ronald R. D. Croy
Grantley W. Lycett
Donald Boulter
Research07 Jan 1982
Nature

Volume: 295, P: 76-79
Potential impact and cost-effectiveness of long-acting injectable lenacapavir plus cabotegravir as HIV treatment in Africa

Long-acting injectable drugs for viral suppression of HIV are not yet available in African settings. Here, the authors present a mathematical modelling and cost effectiveness study of a long-acting drug combination in adults living with HIV in East, Central, Southern and West Africa.

Andrew Phillips
Jennifer Smith
Paul Revill
ResearchOpen Access01 Jul 2025
Nature Communications

Volume: 16, P: 1-13

Search

Filter By:

Search

Quick links