Nature Search

Dietary control of peripheral adipose storage capacity through membrane lipid remodelling

Dietary n-6 PUFAs enhance adipose tissue expandability through the PPARγ–LPCAT3 membrane remodelling axis.

Marcus J. Tol
Yuta Shimanaka
Peter Tontonoz
Research27 Jun 2025
Nature Metabolism

Volume: 7, P: 1424-1442
A higher order PUF complex is central to regulation of C. elegans germline stem cells

PUF proteins, conserved stem cell regulators, maintain germline stem cells with partner proteins in nematodes. Here, authors discover a complex of two FBF-2 PUF proteins and partner LST-1 that represses target mRNA via adjacent regulatory elements.

Chen Qiu
Sarah L. Crittenden
Traci M. Tanaka Hall
ResearchOpen Access02 Jan 2025
Nature Communications

Volume: 16, P: 1-18
Structure of alpha-synuclein fibrils derived from human Lewy body dementia tissue

The accumulation of alpha-synuclein fibrils within neurons is the defining feature of Lewy body dementia (LBD). Here the authors report a method to produce large quantities of alpha-synuclein fibrils that reproduce the complex structure of the fibrils that accumulate in LBD brain tissue.

Dhruva D. Dhavale
Alexander M. Barclay
Paul T. Kotzbauer
ResearchOpen Access29 Mar 2024
Nature Communications

Volume: 15, P: 1-18
Spatiotemporal immune atlas of a clinical-grade gene-edited pig-to-human kidney xenotransplant

Xenotransplantation in humans using pig organs could improve the transplant organ supply. Here the authors transplant pig kidneys into a brain-dead recipient and monitor the human immune cell response early after transplantation using spatial and single cell transcriptomics and show early myeloid cell infiltration.

Matthew D. Cheung
Rebecca Asiimwe
Paige M. Porrett
ResearchOpen Access11 Apr 2024
Nature Communications

Volume: 15, P: 1-15
Somatic mosaicism reveals clonal distributions of neocortical development

A comprehensive analysis of brain somatic mosaicism across the neocortex demonstrates the origins and distribution patterns of cells within the human brain.

Martin W. Breuss
Xiaoxu Yang
Joseph G. Gleeson
Research20 Apr 2022
Nature

Volume: 604, P: 689-696
Defining cellular complexity in human autosomal dominant polycystic kidney disease by multimodal single cell analysis

Autosomal dominant polycystic kidney disease (ADPKD) is a complicated disease that involves numerous cell types. Here the authors used a multiomics approach consisting of single nucleus transcriptomes and epigenomes to redefine cell states in ADPKD and to dissect the cellular interactions and molecular mechanisms of ADPKD.

Yoshiharu Muto
Eryn E. Dixon
Benjamin D. Humphreys
ResearchOpen Access30 Oct 2022
Nature Communications

Volume: 13, P: 1-19
Comprehensive multi-omic profiling of somatic mutations in malformations of cortical development

This Brain Somatic Mosaicism Network analysis of 283 cases of malformations of cortical development identifies 69 candidate and known genes in 76 patients. Single-nucleus RNA sequencing and mouse modeling implicate radial glia and daughter excitatory neurons.

Changuk Chung
Xiaoxu Yang
Joseph G. Gleeson
Research12 Jan 2023
Nature Genetics

Volume: 55, P: 209-220
Hexokinase-2 depletion inhibits glycolysis and induces oxidative phosphorylation in hepatocellular carcinoma and sensitizes to metformin

Hexokinase 2 (HK2) is selectively upregulated in hepatocellular carcinoma (HCC). Here the authors show that HK2 ablation decreases glycolysis and triggers oxidative phosphorylation (OXPHO) rendering HCC more susceptible to the OXPHO inhibitor metformin and to the FDA-approved drug sorafenib.

Dannielle DeWaal
Veronique Nogueira
Nissim Hay
ResearchOpen Access31 Jan 2018
Nature Communications

Volume: 9, P: 1-14
A conserved RNA-binding protein controls germline stem cells in Caenorhabditis elegans

Sarah L. Crittenden
David S. Bernstein
Judith Kimble
Research22 May 2002
Nature

Volume: 417, P: 660-663
Single-cell transcriptomic landscape of the developing human spinal cord

Andersen, Thom and colleagues reveal the single-cell-resolution transcriptome of the midgestation human spinal cord and discover remarkable heterogeneity across and within cell types.

Jimena Andersen
Nicholas Thom
Sergiu P. Pașca
Research24 Apr 2023
Nature Neuroscience

Volume: 26, P: 902-914
A high-throughput method for the quantitative analysis of auxins

Lana S Barkawi
Yuen-Yee Tam
Jerry D Cohen
Protocols09 Sept 2010
Nature Protocols

Volume: 5, P: 1609-1618
Cost-effective high-throughput single-haplotype iterative mapping and sequencing for complex genomic structures

This protocol describes SHIMS 2.0, a method to generate accurate reference sequences from structurally complex genomic regions in a cost-effective, high-throughput manner.

Daniel W Bellott
Ting-Jan Cho
David C Page
Protocols22 Mar 2018
Nature Protocols

Volume: 13, P: 787-809
Protein kinase 2 of the giant sarcomeric protein UNC-89 regulates mitochondrial morphology and function

UNC-89, a giant protein localized to muscle sarcomeres, contains 2 protein kinase domains, one of which, PK2 is a canonical kinase. A missense mutation expected to inactivate PK2 results in worms with an unexpected phenotype suggesting signaling from sarcomeres to mitochondria.

Yohei Matsunaga
Hiroshi Qadota
Guy M. Benian
ResearchOpen Access17 Oct 2024
Communications Biology

Volume: 7, P: 1-16
MULTI-seq: sample multiplexing for single-cell RNA sequencing using lipid-tagged indices

Tagging live single cells and nuclei with lipid- or cholesterol-modified oligonucleotides enables massive scRNA-seq sample multiplexing, identifies doublets and recovers cells with low RNA content.

Christopher S. McGinnis
David M. Patterson
Zev J. Gartner
Research17 Jun 2019
Nature Methods

Volume: 16, P: 619-626
Vegetable omega-3 and omega-6 fatty acids differentially modulate the antiviral and antibacterial immune responses of Atlantic salmon

Albert Caballero-Solares
Khalil Eslamloo
Matthew L. Rise
ResearchOpen Access13 May 2024
Scientific Reports

Volume: 14, P: 1-18
The mutational decay of male-male and hermaphrodite-hermaphrodite competitive fitness in the androdioecious nematode C. elegans

Shu-Dan Yeh
Ayush Shekhar Saxena
Charles F. Baer
Research14 Nov 2017
Heredity

Volume: 120, P: 1-12
Dosage compensation and DNA methylation landscape of the X chromosome in mouse liver

Christopher G. Duncan
Sara A. Grimm
Paul A. Wade
ResearchOpen Access04 Jul 2018
Scientific Reports

Volume: 8, P: 1-17
Ly6C^hi inflammatory monocytes promote susceptibility to Leishmania donovani infection

Cesar Terrazas
Sanjay Varikuti
Abhay R. Satoskar
ResearchOpen Access31 Oct 2017
Scientific Reports

Volume: 7, P: 1-10
Migration-associated secretion of melanoma inhibitory activity at the cell rear is supported by KCa3.1 potassium channels

Jennifer Schmidt
Kristin Friebel
Anja-Katrin Bosserhoff
Research24 Aug 2010
Cell Research

Volume: 20, P: 1224-1238
Zebrafishology, study design guidelines for rigorous and reproducible data using zebrafish

A review emphasizes the advantages of using zebrafish in research, outlines key differences in experimental approaches, and offers guidelines for designing studies in a way that enhances experimental rigor and reproducibility.

Victoria M. Bedell
Priya Dubey
Stephen C. Ekker
ReviewsOpen Access13 May 2025
Communications Biology

Volume: 8, P: 1-14

Search

Dietary control of peripheral adipose storage capacity through membrane lipid remodelling

A higher order PUF complex is central to regulation of C. elegans germline stem cells

Structure of alpha-synuclein fibrils derived from human Lewy body dementia tissue

Spatiotemporal immune atlas of a clinical-grade gene-edited pig-to-human kidney xenotransplant

Somatic mosaicism reveals clonal distributions of neocortical development

Defining cellular complexity in human autosomal dominant polycystic kidney disease by multimodal single cell analysis

Comprehensive multi-omic profiling of somatic mutations in malformations of cortical development

Hexokinase-2 depletion inhibits glycolysis and induces oxidative phosphorylation in hepatocellular carcinoma and sensitizes to metformin

A conserved RNA-binding protein controls germline stem cells in Caenorhabditis elegans

Single-cell transcriptomic landscape of the developing human spinal cord

A high-throughput method for the quantitative analysis of auxins

Cost-effective high-throughput single-haplotype iterative mapping and sequencing for complex genomic structures

Protein kinase 2 of the giant sarcomeric protein UNC-89 regulates mitochondrial morphology and function

MULTI-seq: sample multiplexing for single-cell RNA sequencing using lipid-tagged indices

Vegetable omega-3 and omega-6 fatty acids differentially modulate the antiviral and antibacterial immune responses of Atlantic salmon

The mutational decay of male-male and hermaphrodite-hermaphrodite competitive fitness in the androdioecious nematode C. elegans

Dosage compensation and DNA methylation landscape of the X chromosome in mouse liver

Ly6C^hi inflammatory monocytes promote susceptibility to Leishmania donovani infection

Migration-associated secretion of melanoma inhibitory activity at the cell rear is supported by KCa3.1 potassium channels

Zebrafishology, study design guidelines for rigorous and reproducible data using zebrafish

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