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Showing 1–10 of 10 results
Advanced filters: Author: Jeronimo Rodriguez-Beltran Clear advanced filters

  • Plasmids exhibit a broad range of sizes and copies per cell, and these two parameters appear to be negatively correlated. Here, Ramiro-Martínez et al. analyse the copy number of thousands of diverse bacterial plasmids in relation to their genomic context, hosts, and other features, and develop a universal scaling law that links copy number and plasmid size across bacterial species.

    • Paula Ramiro-Martínez
    • Ignacio de Quinto
    • Jerónimo Rodríguez-Beltrán
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-11

  • Recent studies have revealed that the evolutionary impact of plasmids goes above and beyond their being mere gene delivery platforms. In this Review, Rodríguez-Beltrán, San Millán and colleagues discuss the advances that underscore the importance of plasmids in bacterial ecology and evolution beyond horizontal gene transfer.

    • Jerónimo Rodríguez-Beltrán
    • Javier DelaFuente
    • Álvaro San Millán
    Reviews
    Nature Reviews Microbiology
    Volume: 19, P: 347-359

  • Trade-offs are common during evolutionary innovation. Here, the authors show that multicopy plasmids allow coexistence of the ancestral and evolved alleles in the TEM-1 β-lactamase system, helping bacteria to escape evolutionary constraints imposed by trade-offs.

    • Jeronimo Rodriguez-Beltran
    • J. Carlos R. Hernandez-Beltran
    • Alvaro San Millan
    Research
    Nature Ecology & Evolution
    Volume: 2, P: 873-881

  • In this work, authors combine computational models with single-cell and population-level data showing the variability in plasmid copy number within bacterial populations leads to phenotypic diversity. They reveal how multicopy plasmids contribute to bacterial transient antibiotic resistance.

    • J. Carlos R. Hernandez-Beltran
    • Jerónimo Rodríguez-Beltrán
    • Rafael Peña-Miller
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-13

  • Combining experimental and within-patient evolution analyses, the authors show that the widespread conjugative plasmid pOXA-48 promotes bacterial evolution through the transposition of plasmid-encoded insertion sequence IS1 elements.

    • Jorge Sastre-Dominguez
    • Javier DelaFuente
    • Alvaro San Millan
    Research
    Nature Ecology & Evolution
    Volume: 8, P: 2097-2112

  • A combination of analysis of plasmid diversity in the gut of hospitalized patients with experimental evolution shows that the evolution of plasmid-mediated antibiotic resistance involves a trade-off between antibiotic resistance levels and bacterial fitness.

    • Javier DelaFuente
    • Laura Toribio-Celestino
    • Alvaro San Millan
    Research
    Nature Ecology & Evolution
    Volume: 6, P: 1980-1991

  • The variability of plasmid fitness effects on wild-type bacterial hosts have been largely unknown until this study, which shows that plasmid persistence increases with bacterial diversity and becomes less dependent on conjugation. This could explain why plasmids remain so common in nature.

    • Aida Alonso-del Valle
    • Ricardo León-Sampedro
    • Alvaro San Millán
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-14