The transcription factor KLF2 has been thought to control survival of T lymphocytes, as KLF2-deficient T cells develop in the thymus, but fail to populate the peripheral lymphoid organs. But this report shows that the phenotype results from an unexpected role of KLF2 in regulating the expression of lymphocyte trafficking molecules.
- Corey M. Carlson
- Bart T. Endrizzi
- Stephen C. Jameson