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Barcoded viral tracing identifies immunosuppressive astrocyte–glioma interactions

Using viral barcode tracing to detect interactions between glioblastoma cells and non-malignant astrocytes in patient samples, investigators discovered a pathway that reduces tumour-specific immunity and identified potential therapeutic targets.

Brian M. Andersen
Camilo Faust Akl
Francisco J. Quintana
Research25 Jun 2025
Nature

Volume: 644, P: 1097-1106
Author Correction: Disease-associated astrocyte epigenetic memory promotes CNS pathology

Hong-Gyun Lee
Joseph M. Rone
Francisco J. Quintana
Amendments and Corrections21 Jun 2024
Nature

Volume: 631, P: E8
Identification of environmental factors that promote intestinal inflammation

The herbicide propyzamide increases inflammation in the small and large intestine, and the AHR–NF-κB–C/EBPβ signalling axis—which operates in T cells and dendritic cells to promote intestinal inflammation—is targeted by propyzamide.

Liliana M. Sanmarco
Chun-Cheih Chao
Francisco J. Quintana
Research20 Oct 2022
Nature

Volume: 611, P: 801-809
Author Correction: Disease-associated astrocyte epigenetic memory promotes CNS pathology

Hong-Gyun Lee
Joseph M. Rone
Francisco J. Quintana
Amendments and Corrections26 Aug 2025
Nature

Volume: 645, P: E5
Glioblastoma-instructed astrocytes suppress tumour-specific T cell immunity

A population of TRAIL-positive astrocytes in glioblastoma contributes to an immunosuppressive tumour microenvironment and this mechanism can be targeted with an engineered oncolytic virus to improve outcomes.

Camilo Faust Akl
Brian M. Andersen
Francisco J. Quintana
Research21 May 2025
Nature

Volume: 643, P: 219-229
Disease-associated astrocyte epigenetic memory promotes CNS pathology

In an experimental autoimmune encephalomyelitis model in mice, a subset of astrocytes retains an epigenetically regulated memory of past inflammation, causing exacerbated inflammation upon subsequent rechallenge.

Hong-Gyun Lee
Joseph M. Rone
Francisco J. Quintana
Research20 Mar 2024
Nature

Volume: 627, P: 865-872
Lactate limits CNS autoimmunity by stabilizing HIF-1α in dendritic cells

Lactate produced by dendritic cells (DCs) suppresses T-cell-mediated autoimmunity through a mechanism in which lactate activates HIF-1α–NDUFA4L2 signalling in DCs and thereby limits DC-mediated pro-inflammatory responses such as the development of encephalitogenic T cells.

Liliana M. Sanmarco
Joseph M. Rone
Francisco J. Quintana
Research09 Aug 2023
Nature

Volume: 620, P: 881-889
Detection of aryl hydrocarbon receptor agonists in human samples

Veit Rothhammer
Davis M. Borucki
Francisco J. Quintana
ResearchOpen Access21 Mar 2018
Scientific Reports

Volume: 8, P: 1-8
Control of tumor-associated macrophages and T cells in glioblastoma via AHR and CD39

Using animal models and clinical samples, the authors report that glioblastoma metabolites activate the transcription factor aryl hydrocarbon receptor in tumor-associated macrophages to modulate their function and T cell immunity, promoting tumor growth.

Maisa C. Takenaka
Galina Gabriely
Francisco J. Quintana
Research08 Apr 2019
Nature Neuroscience

Volume: 22, P: 729-740
Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor

After upregulation of AHR in astrocytes by type I interferons, commensal-microbe-derived metabolites of dietary tryptophan act on astrocytes to suppress CNS inflammation.

Veit Rothhammer
Ivan D Mascanfroni
Francisco J Quintana
Research09 May 2016
Nature Medicine

Volume: 22, P: 586-597
Metabolic control of type 1 regulatory T cell differentiation by AHR and HIF1-α

Metabolic changes induced by hypoxia and extracellular ATP, acting through the transcription factors HIF1-α and AHR, regulate the differentiation of type 1 regulatory (T_reg1) cells.

Ivan D Mascanfroni
Maisa C Takenaka
Francisco J Quintana
Research25 May 2015
Nature Medicine

Volume: 21, P: 638-646
Therapeutic induction of antigen-specific immune tolerance

The induction of antigen-specific immune tolerance is considered the 'holy grail' of disease management for autoimmunity and organ transplantation. Are we getting any closer to this goal? Here, the authors update us on the current progress and challenges to the therapeutic induction of antigen-specific immune tolerance.

Jessica E. Kenison
Nikolas A. Stevens
Francisco J. Quintana
Reviews12 Dec 2023
Nature Reviews Immunology

Volume: 24, P: 338-357

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