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Showing 1–50 of 251 results
Advanced filters: Author: Jessica McHugh Clear advanced filters

  • Understanding collective behaviour is an important aspect of managing the pandemic response. Here the authors show in a large global study that participants that reported identifying more strongly with their nation reported greater engagement in public health behaviours and support for public health policies in the context of the pandemic.

    • Jay J. Van Bavel
    • Aleksandra Cichocka
    • Paulo S. Boggio
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-14

  • An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

    • Erola Pairo-Castineira
    • Konrad Rawlik
    • J. Kenneth Baillie
    ResearchOpen Access
    Nature
    Volume: 617, P: 764-768

  • Researchers have identified a mechanistic link between SARS-CoV-2 infection and multisystem inflammatory syndrome in children, providing evidence for the involvement of molecular mimicry.

    • Jessica McHugh
    Research Highlights
    Nature Reviews Rheumatology
    Volume: 20, P: 598

  • The bispecific T cell engager (BiTE) blinatumomab showed promising clinical efficacy in a pilot study of six patients with multidrug-resistant rheumatoid arthritis.

    • Jessica McHugh
    Research Highlights
    Nature Reviews Rheumatology
    Volume: 20, P: 395

  • The voltage-gated sodium channel Nav1.7 is expressed on chondrocytes, regulates chondrocyte biology and osteoarthritis progression, and is a promising dual target for modifying disease while providing pain relief in osteoarthritis.

    • Jessica McHugh
    Research Highlights
    Nature Reviews Rheumatology
    Volume: 20, P: 137

  • A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

    • Mari E. K. Niemi
    • Juha Karjalainen
    • Chloe Donohue
    ResearchOpen Access
    Nature
    Volume: 600, P: 472-477

  • Researchers have conducted a comprehensive single-cell analysis of synovial tissue in rheumatoid arthritis, providing insights into the heterogeneity of the disease and informing future treatment strategies.

    • Jessica McHugh
    Research Highlights
    Nature Reviews Rheumatology
    Volume: 20, P: 4

  • Researchers have introduced the term ‘MDA5-autoimmunity and interstitial pneumonitis contemporaneous with the COVID-19 pandemic’ (MIP-C) to describe cases of MDA5 autoimmunity that surged during the COVID-19 pandemic.

    • Jessica McHugh
    Research Highlights
    Nature Reviews Rheumatology
    Volume: 20, P: 395

  • New findings identify HSP60 and other synovial stromal-derived autoantigens as targets for pathogenic autoantibodies, exacerbating arthritis and serving as potential biomarkers.

    • Jessica McHugh
    Research Highlights
    Nature Reviews Rheumatology
    Volume: 20, P: 527

  • Type 2 innate lymphoid cells protect against kidney inflammation in lupus nephritis, and enhancing their adhesion via integrin α4β7 upregulation, particularly through IL-33 treatment, could be a promising therapeutic approach.

    • Jessica McHugh
    Research Highlights
    Nature Reviews Rheumatology
    Volume: 20, P: 455

  • Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

    • Athanasios Kousathanas
    • Erola Pairo-Castineira
    • J. Kenneth Baillie
    ResearchOpen Access
    Nature
    Volume: 607, P: 97-103

  • New findings provide insight into the natural history of subclinical synovitis, a reported predictor of the development of rheumatoid arthritis, and identify various factors associated with its reversal.

    • Jessica McHugh
    Research Highlights
    Nature Reviews Rheumatology
    Volume: 20, P: 138

  • New findings suggest that targeting the DAMP protein S100A4 could mitigate both inflammatory and fibrotic pathways in systemic sclerosis.

    • Jessica McHugh
    Research Highlights
    Nature Reviews Rheumatology
    Volume: 20, P: 67

  • A new study reveals a non-canonical function for the histone demethylase JMJD1C that restrains plasma cell differentiation and protects mice from experimental arthritis.

    • Jessica McHugh
    Research Highlights
    Nature Reviews Rheumatology
    Volume: 18, P: 553

  • Dual inhibition of glycolysis and glutaminolysis in fibroblast-like synoviocytes with a compound called c28MS shows promise in a mouse model of rheumatoid arthritis

    • Jessica McHugh
    Research Highlights
    Nature Reviews Rheumatology
    Volume: 19, P: 760

  • Methotrexate reduces pain and stiffness in hand osteoarthritis with synovitis, according to the results of a new randomized controlled trial.

    • Jessica McHugh
    Research Highlights
    Nature Reviews Rheumatology
    Volume: 20, P: 3

  • New research shows that the FGF10–FGFR1 axis is highly activated in lining fibroblast-like synoviocytes during relapsing rheumatoid arthritis and is a potential therapeutic target.

    • Jessica McHugh
    Research Highlights
    Nature Reviews Rheumatology
    Volume: 19, P: 677

  • A study of the evolution of the SARS-CoV-2 virus in England between September 2020 and June 2021 finds that interventions capable of containing previous variants were insufficient to stop the more transmissible Alpha and Delta variants.

    • Harald S. Vöhringer
    • Theo Sanderson
    • Moritz Gerstung
    ResearchOpen Access
    Nature
    Volume: 600, P: 506-511

  • New findings implicate TAp63 as a potential target of methotrexate in T cells, providing insight in the mechanism of action of this drug, including its suppressive effects on regulatory T cells.

    • Jessica McHugh
    Research Highlights
    Nature Reviews Rheumatology
    Volume: 19, P: 461

  • In screening for post-translational modifications associated with ankylosing spondylitis, researchers have identified a microbiome-metabolite-mediated modification that can lead to neoantigen generation and subsequent autoimmunity.

    • Jessica McHugh
    Research Highlights
    Nature Reviews Rheumatology
    Volume: 19, P: 325

  • Platelet activity and the formation of monocyte–platelet aggregates contribute to the production of IL-1β and the development of cardiovascular lesions in Kawasaki disease.

    • Jessica McHugh
    Research Highlights
    Nature Reviews Rheumatology
    Volume: 19, P: 537

  • New findings suggest that liposome-mediated delivery of a specific microRNA inhibitor can restore anti-inflammatory macrophage polarization and reduce joint inflammation in mice.

    • Jessica McHugh
    Research Highlights
    Nature Reviews Rheumatology
    Volume: 19, P: 606

  • Characterization of a new mouse model highlights allogeneic bone marrow transplantation and granulocyte colony-stimulating factor neutralization as potential avenues for the treatment of APLAID.

    • Jessica McHugh
    Research Highlights
    Nature Reviews Rheumatology
    Volume: 19, P: 326

  • In a phase III trial, the oral Janus kinase inhibitor baricitinib was safe and effective in patients with juvenile idiopathic arthritis who previously had an inadequate response to DMARD therapy.

    • Jessica McHugh
    Research Highlights
    Nature Reviews Rheumatology
    Volume: 19, P: 539

  • Cognitive functional therapy is a safe, effective and low-cost intervention for individuals with persistent disabling low back pain, according to results from the phase III RESTORE trial.

    • Jessica McHugh
    Research Highlights
    Nature Reviews Rheumatology
    Volume: 19, P: 397

  • The ACR has developed its first guideline for managing rheumatoid arthritis using integrative interventions, to aid in decision-making regarding such approaches alongside pharmacological treatment.

    • Jessica McHugh
    Research Highlights
    Nature Reviews Rheumatology
    Volume: 19, P: 462

  • HIF-1 can regulate the cytotoxic activity of skin-infiltrating T cells in cutaneous lupus erythematosus and is a potential therapeutic target.

    • Jessica McHugh
    Research Highlights
    Nature Reviews Rheumatology
    Volume: 19, P: 607

  • Notch signalling in the peripheral nervous system is involved in mediating pain in a mouse model of osteoarthritis.

    • Jessica McHugh
    Research Highlights
    Nature Reviews Rheumatology
    Volume: 19, P: 395