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Persistent synthesis challenges constrain the stabilization of single-atom lanthanide catalysts across many substrates. Using a method based on molten-nitrite chemistry, the atomic dispersion of lanthanide atoms on diverse substrates is achieved and exemplified by Dy₁/Pt for acidic hydrogen evolution.

Ammonia offers benefits like easy storage, high cooling capacity, and carbon-free combustion for high-Mach scramjets, but its low-Mach operation is challenging. Here, authors demonstrate the feasibility of ammonia-hydrogen ignition at Mach 3 and sustained combustion at Mach 6.

This study shows that acidification increases substrate affinity in ammonia-oxidizing microbes, partly offsetting reduced ammonia availability. Stronger responses in archaea than bacteria explain contrasting ecosystem reactions.

Freestanding membranes of hexagonal oxides remain difficult to obtain. In this work, a water-soluble crystalline hexagonal BaAl₂O₄ is found to serve as a sacrificial layer for obtaining freestanding membranes with six-fold or three-fold symmetry.

Molecular glue degraders have consistently been discovered retrospectively, despite their increasing importance. Herein, a high-throughput approach is described that modifies existing ligands into molecular glue degraders.

A strategy using simple one-step spin-coating to form 3D/2D vertically oriented perovskite heterojunctions is described, allowing the fabrication of perovskite light-emitting diodes with record-high green emission efficiencies of 42.9% (certified 42.3%).

The authors consider the changing sensitivity of the leaf-onset date to temperature (S_T) for boreal deciduous broadleaf forests. S_T increased between 1982–1996 and 1998–2012—potentially linked to enhanced chilling accumulation—but this increase is underestimated in phenology models.

Thymine DNA glycosylase (TDG) was identified as a synthetic-lethal target in p53-deficient cancers through alterations in double-stranded RNA accumulation. A covalent small-molecule inhibitor of TDG exhibited potent efficacy against p53-deficient tumors.

This study finds that plastic mulch substantially increases crop yields but also contaminates soils and pollutes the environment. The authors propose biodegradable films, AI-driven farming, and policy reforms to address the productivity–sustainability trade-offs.

Previous studies on biodistribution of microplastics showed discrepancies. This study provides quantitative data to date on how nanoplastics distribute and eliminate from the body using carbon-14-radiolabelled particles in rats.

Catalysed oxidative C-C bond formation reactions are important in the synthesis of natural products, but poorly tolerated by polyphenolic flavones. Here the authors report the reactivity of molecular oxygen in alkaline water without added catalyst for the synthesis of a collection of flavone dimers and trimers.

Molecular bilayer crystals of an organic semiconductor can exhibit metallic charge transport down to 8 K with an electrical conductivity of up to 245 S cm⁻¹, as well as charge carrier mobility values of more than 100 cm² V⁻¹ s⁻¹ at 20 K.

Acidic electrochemical CO₂ reduction promises efficient carbon use, but maintaining stable acidity at high current remains a major challenge. Here, the authors demonstrate a membrane-free CO₂ hydrogenation electrolyzer that stabilizes pH and enables efficient and stable formic acid production.

Recently superconductivity was observed in La₃Ni₂O₇ ultrathin film grown on the SrLaAlO₄ substrate with T_c ≈ 40 K at ambient pressure. Here, the authors propose that an imposed strong perpendicular electric field can strongly enhance the T_c in the single-bilayer film of La₃Ni₂O₇ at ambient pressure.

The STAR experiment at the Relativistic Heavy Ion Collider at Brookhaven National Laboratory demonstrates evidence of spin correlations in \(\Lambda \bar{\Lambda }\) hyperon pairs inherited from virtual spin-correlated strange quark–antiquark pairs during QCD confinement.

Extracting rare earth elements (REEs) from wastewater is essential for the growth of an eco-friendly sustainable economy but separating individual rare earth elements remains challenging. Here, the authors report a REE nanotrap that features dense uncoordinated carboxyl groups and triazole N atoms in a two-fold interpenetrated metalorganic framework which is highly responsive to the size variation of rareearth ions.

Metal nanoclusters are promising for flexible light-emitting diodes but face efficiency and stability challenges. Here, the authors employ a π-conjugated mediator to align dipole alignment, yielding devices with 26.4% external quantum efficiency and 94% efficiency retention after 2000 bending cycles.

The Taiwan Precision Medicine Initiative recruited and genotyped more than half a million Taiwanese participants, almost all of Han Chinese ancestry, and performed comprehensive genomic analyses and developed polygenic risk score prediction models for numerous health conditions.

Converting phenol in wastewater into valuable chemicals through electrochemical hydrogenation offers a sustainable route for resource recovery but lacks efficient catalysts. Here, the authors report a hierarchical Ru⁰/Ru^δ+/Al₂O₃ catalyst to achieve selective conversion of phenol to cyclohexanol.

Here, combining data from a clinical trial and animal models, the authors show a role for a gut-acylcarnitine axis in the development of salt-sensitive hypertension, and identify isovalerylcarnitine as a key microbiota-derived modulator and potential target for the precision prevention of hypertension.

Hepatocyte-specific GPR110 mediates metabolic dysfunction-associated steatohepatitis progression by regulating hepatic oestrogen sensitivity in a sex-specific manner, specifically in female mice.

An efficient approach is developed to enforce spin symmetry for neural network wavefunctions when solving the many-body Schrödinger equation. This enables accurate and spin-pure simulations of both ground and excited states.

Hanging Coffins were a mortuary tradition practiced in southern China and Southeast Asia. Here, the authors show that different groups of ancient Hanging Coffin practitioners are genetically related, and that they are ancestors of present-day Bo people.

The ALICE Collaboration provides details on the microscopic mechanism that ends up creating antideuteron in high-energy proton–proton collisions at the Large Hadron Collider.

SN16X is upregulated in mouse hypertrophic hearts and accelerates AngII-induced cardiac hypertrophy via enhancing EGFR recycling and transactivation.

A newly identified coronavirus isolated from farmed minks can use the receptor ACE2 to infect cells of different mammalian species, including human cells, which has implications for potential zoonotic spillover events.

The Antarctic Circumpolar Current (ACC) since the Last Interglacial is reconstructed, showing orbital-scale shifts in ACC position driven by eccentricity and precession, possibly counteracting the predicted southward shift due to global warming.

In this study, the authors present that patterned low-intensity ultrasound mimicking brainwave rhythms revitalizes spinal astrocytes to normalize pain signaling, reversing inflammation and providing long-lasting relief from neuropathic pain in mice.

Endothelialization of the left atrial appendage (LAA) occluder is vital in addressing device-related thrombosis. Here, the authors report LAA occluders integrated with drop-shaped microgrooves to guide unidirectional cell migration for enhanced endothelialization.

Polygenic scores for body mass index and obesity constructed using data from 5 million people with different ancestries were associated with distinct weight gain trajectories from early childhood to adulthood.

How did amphibious plants evolve the convergent strategy to escape submergence by fast shoot elongation? Yang et al. reveal the pivotal role of a cis-regulatory element in the PHYA promoter in promoting submergence-induced plastic growth of amphibious plants.

Reconstructing transcription–translation-coupled DNA replication (TTcDR) in artificial systems is crucial for creating synthetic life. Here the authors develop LoopReX, a TTcDR which leverages minimal machinery and artificial nucleoids to support multiple biological functions.

A DNA matrix material potentiates humoral response through multiple administration routes, generating neutralizing antibodies and conferring robust protection against infection.

Most of the world’s food relies on nitrogen and phosphorus fertilizers, but how efficiently crops use these nutrients has remained unclear globally. This study provides global-scale evidence of persistently low nutrient use efficiency with clear crop- and region-specific patterns, offering insights to guide sustainable fertilizer management.

FACED 2.0 builds on and expands the capabilities of the free-space angular-chirp-enhanced delay microscopy approach. Its high speed, large field of view and volumetric coverage enable two-photon voltage imaging of hundreds of neurons or calcium imaging of thousands of neurons in the mouse or zebrafish brain.

PCBP2 is elevated in AD and forms condensates that sequester mitochondrial proteins and RBPs, disrupting mitochondrial function and the NMD of BACE1 mRNA, alongside amyloid deposition. The small molecule, CN-0928 mitigates AD pathology by inhibiting PCBP2 condensation.

A cross-ancestry GWAS meta-analyses of brainstem structures identify 713 associations. It reveals shared/distinct genetic architectures across ancestries/substructures and overlaps with neuropsychiatric disorders and physiological functions.

The Rauhut-Currier reaction is a powerful method to form carbon-carbon bonds. Here, the authors report an enantioselective intramolecular variant between alkenes and allenoates, giving access to highly functionalised bicyclic lactones in excellent enantiomeric excess.

Ammonia cracking for H₂ is vital, but inexpensive Ni catalyst needs high temperatures due to slow N–N coupling. A photothermal Ni–CeO₂₋x/CNT with defect-rich interfaces speeds N–H cleavage, eases N–N coupling, delivering high H₂ rates and 50 h stability.

Here, the authors demonstrate increased global lactylation levels and in the joints of rheumatoid arthritis patients. NFATc2 is identified as a key target gene regulated by histone H3 lysine 9 lactylation that exacerbates disease progression by enhancing the cartilage invasive function of fibroblast-like synoviocytes.