Nature Search

Construction of the axolotl cell landscape using combinatorial hybridization sequencing at single-cell resolution

The Mexican axolotl is a well-established tetrapod model for regeneration and development. Here the authors report a scRNA-seq method to profile neotenic, metamorphic and limb development stages, highlighting unique perturbation patterns of cell type-related gene expression throughout metamorphosis.

Fang Ye
Guodong Zhang
Guoji Guo
ResearchOpen Access22 Jul 2022
Nature Communications

Volume: 13, P: 1-18
RAB39B gene mutations are not linked to familial Parkinson’s disease in China

Ji-feng Kang
Yang Luo
Ji-feng Guo
ResearchOpen Access03 Oct 2016
Scientific Reports

Volume: 6, P: 1-3
Author Correction: The axolotl genome and the evolution of key tissue formation regulators

Sergej Nowoshilow
Siegfried Schloissnig
Eugene W. Myers
Amendments and Corrections23 May 2018
Nature

Volume: 559, P: E2
SEAD reference panel with 22,134 haplotypes boosts rare variant imputation and genome-wide association analysis in Asian populations

Limited whole genome sequencing (WGS) of Asian populations results in a lack of representative reference panels, hindering imputation of Asian ancestry-specific genetic variants. Here the authors use WGS data from 11,067 individuals across 17 Asian countries to create a new reference panel which shows improved imputation accuracy for South Asian populations.

Meng-Yuan Yang
Jia-Dong Zhong
Hou-Feng Zheng
ResearchOpen Access30 Dec 2024
Nature Communications

Volume: 15, P: 1-14
Pirt reduces bladder overactivity by inhibiting purinergic receptor P2X3

The cause of overactive bladder is largely unknown and there is currently no effective therapy. Gaoet al. show that a membrane protein Pirt controls bladder emptying by inhibiting the neuronal purinergic receptor P2X3 and that treatment with a small Pirt fragment prevents bladder overactivity in mice.

Xiao-Fei Gao
Ji-Feng Feng
Cheng He
Research07 Jul 2015
Nature Communications

Volume: 6, P: 1-11
Genomic and chemical profiling of Botryosphaeria dothidea: cryptic biosynthetic gene clusters and secondary metabolites in agarwood formation

Xiao-Yan Duan
Dong-Bao Hu
Yue-Hu Wang
Research19 Sept 2025
The Journal of Antibiotics

P: 1-9
Publisher Correction: Application and optimization of CRISPR–Cas9-mediated genome engineering in axolotl (Ambystoma mexicanum)

Ji-Feng Fei
Wilson Pak-Kin Lou
Elly M. Tanaka
Amendments and Corrections29 Jan 2019
Nature Protocols

Volume: 14, P: 2597
Author Correction: SpG and SpRY variants expand the CRISPR toolbox for genome editing in zebrafish

Fang Liang
Yu Zhang
Wei Qin
Amendments and CorrectionsOpen Access16 Feb 2023
Nature Communications

Volume: 14, P: 1
Efficient and accurate framework for genome-wide gene-environment interaction analysis in large-scale biobanks

Here, the authors introduce a statistical framework for analyzing gene-environment interactions across diverse traits, effectively addressing ancestry differences while maintaining scalability for largescale genome-wide studies.

Yuzhuo Ma
Yanlong Zhao
Wenjian Bi
ResearchOpen Access29 Mar 2025
Nature Communications

Volume: 16, P: 1-21
Association between neutrophil-to-lymphocyte ratio and differentiated thyroid cancer: a meta-analysis

Ji-Feng Liu
Luo Ba
Xiao-Xia Li
ResearchOpen Access12 Dec 2016
Scientific Reports

Volume: 6, P: 1-7
Cytosine base editors with increased PAM and deaminase motif flexibility for gene editing in zebrafish

Cytosine base editing is crucial for modeling human diseases in zebrafish. Here, the authors present zevoCDA1 and zevoCDA1-198, optimized editors that improve editing efficiency and precision, allowing zebrafish modeling for disease-related mutations which were previously limited by DNA sequence contexts.

Yu Zhang
Yang Liu
Yanmei Liu
ResearchOpen Access04 Nov 2024
Nature Communications

Volume: 15, P: 1-10
The axolotl genome and the evolution of key tissue formation regulators

Sequencing and assembly of the 32-Gb genome of the Mexican axolotl reveals that it lacks the developmental gene Pax3, which is essential in other vertebrates; the genome sequence could improve our understanding of the evolution of the axolotl’s remarkable regenerative capabilities.

Sergej Nowoshilow
Siegfried Schloissnig
Eugene W. Myers
ResearchOpen Access24 Jan 2018
Nature

Volume: 554, P: 50-55
Tissue- and time-directed electroporation of CAS9 protein–gRNA complexes in vivo yields efficient multigene knockout for studying gene function in regeneration

Ji-Feng Fei
Dunja Knapp
Elly M Tanaka
ResearchOpen Access09 Jun 2016
npj Regenerative Medicine

Volume: 1, P: 1-9
Relativistic baryonic jets from an ultraluminous supersoft X-ray source

Persistent low-velocity baryonic jets have been detected from a supersoft X-ray source; the low velocity suggests that these jets have not been launched from a white dwarf, and the persistence speaks against the origin being a canonical black hole or neutron star, indicating that a different type of source must be implicated.

Ji-Feng Liu
Yu Bai
Shri Kulkarni
Research25 Nov 2015
Nature

Volume: 528, P: 108-110
SpG and SpRY variants expand the CRISPR toolbox for genome editing in zebrafish

The recent development of PAM-less base editors makes it possible to assess the functional impact and pathogenicity of nucleotide mutations in animals. Here the authors show that SpG and SpRY could edit NGN and NNN PAMs in zebrafish using the purified protein with synthetically modified gRNA, respectively.

Fang Liang
Yu Zhang
Wei Qin
ResearchOpen Access14 Jun 2022
Nature Communications

Volume: 13, P: 1-10
Association of rare PPARGC1A variants with Parkinson’s disease risk

Li-zhi Li
Yu-wen Zhao
Ji-feng Guo
Research22 Aug 2022
Journal of Human Genetics

Volume: 67, P: 687-690
Altered developmental programs and oriented cell divisions lead to bulky bones during salamander limb regeneration

Normal limb development relies on synchronized formation of cartilage and bone. Here, the authors show that in salamander limb regeneration these processes are decoupled: ossification occurs after the final size of regenerating cartilage is reached, allowing fast regeneration and leading to bulky bones.

Marketa Kaucka
Alberto Joven Araus
Igor Adameyko
ResearchOpen Access14 Nov 2022
Nature Communications

Volume: 13, P: 1-17
Abnormal lithium isotope composition from the ancient lithospheric mantle beneath the North China Craton

Yan-Jie Tang
Hong-Fu Zhang
Yan Xiao
ResearchOpen Access04 Mar 2014
Scientific Reports

Volume: 4, P: 1-4
Proline-rich protein PRR19 functions with cyclin-like CNTD1 to promote meiotic crossing over in mouse

Crossing over is a critical process during meiosis, although the regulation of this process still remains somewhat elusive. Here, the authors show that PRR19 partners with CNTD1 to enable formation of crossover-specific recombination complexes in mouse germ cells.

Anastasiia Bondarieva
Kavya Raveendran
Attila Tóth
ResearchOpen Access18 Jun 2020
Nature Communications

Volume: 11, P: 1-20
A new immunotherapy strategy targeted CD30 in peripheral T-cell lymphomas: CAR-modified T-cell therapy based on CD30 mAb

Yang Wu
Dan Chen
Jian-Zhong Wu
ResearchOpen Access29 Jan 2021
Cancer Gene Therapy

Volume: 29, P: 167-177
Puzzling accretion onto a black hole in the ultraluminous X-ray source M 101 ULX-1

The ultraluminous X-ray source M 101 ULX-1 consists of a black hole orbiting a Wolf-Rayet star; optical spectroscopy now shows that the orbital period is 8.2 days, suggesting that the black hole has a mass in the range 5 to 30 solar masses, though the X-ray spectra are unlike what is expected from accretion onto a stellar-mass black hole—accretion must occur from captured stellar wind, which has hitherto been thought to be so inefficient that it could not power an ultraluminous source.

Ji-Feng Liu
Joel N. Bregman
Paul Crowther
Research27 Nov 2013
Nature

Volume: 503, P: 500-503
Polymorphism in the 3′-untranslated region of the thymidylate synthase gene and sensitivity of stomach cancer to fluoropyrimidine-based chemotherapy

Jian-Wei Lu
Chang-Ming Gao
Ji-Feng Feng
Research01 Mar 2006
Journal of Human Genetics

Volume: 51, P: 155-160
Application and optimization of CRISPR–Cas9-mediated genome engineering in axolotl (Ambystoma mexicanum)

This protocol describes strategies for targeted genome modification in axolotls. Eggs are injected with a CAS9–gRNA ribonucleoprotein complex, which allows for efficient generation of knockout and knock-in animals and immediate phenotypic analysis.

Ji-Feng Fei
Wilson Pak-Kin Lou
Elly M. Tanaka
Protocols14 Nov 2018
Nature Protocols

Volume: 13, P: 2908-2943
A scATAC-seq atlas of chromatin accessibility in axolotl brain regions

Weimin Feng
Shuai Liu
Xiaoyu Wei
ResearchOpen Access14 Sept 2023
Scientific Data

Volume: 10, P: 1-10

Search

Construction of the axolotl cell landscape using combinatorial hybridization sequencing at single-cell resolution

RAB39B gene mutations are not linked to familial Parkinson’s disease in China

Author Correction: The axolotl genome and the evolution of key tissue formation regulators

SEAD reference panel with 22,134 haplotypes boosts rare variant imputation and genome-wide association analysis in Asian populations

Pirt reduces bladder overactivity by inhibiting purinergic receptor P2X3

Genomic and chemical profiling of Botryosphaeria dothidea: cryptic biosynthetic gene clusters and secondary metabolites in agarwood formation

Publisher Correction: Application and optimization of CRISPR–Cas9-mediated genome engineering in axolotl (Ambystoma mexicanum)

Author Correction: SpG and SpRY variants expand the CRISPR toolbox for genome editing in zebrafish

Efficient and accurate framework for genome-wide gene-environment interaction analysis in large-scale biobanks

Association between neutrophil-to-lymphocyte ratio and differentiated thyroid cancer: a meta-analysis

Cytosine base editors with increased PAM and deaminase motif flexibility for gene editing in zebrafish

The axolotl genome and the evolution of key tissue formation regulators

Tissue- and time-directed electroporation of CAS9 protein–gRNA complexes in vivo yields efficient multigene knockout for studying gene function in regeneration

Relativistic baryonic jets from an ultraluminous supersoft X-ray source

SpG and SpRY variants expand the CRISPR toolbox for genome editing in zebrafish

Association of rare PPARGC1A variants with Parkinson’s disease risk

Altered developmental programs and oriented cell divisions lead to bulky bones during salamander limb regeneration

Abnormal lithium isotope composition from the ancient lithospheric mantle beneath the North China Craton

Proline-rich protein PRR19 functions with cyclin-like CNTD1 to promote meiotic crossing over in mouse

A new immunotherapy strategy targeted CD30 in peripheral T-cell lymphomas: CAR-modified T-cell therapy based on CD30 mAb

Puzzling accretion onto a black hole in the ultraluminous X-ray source M 101 ULX-1

Polymorphism in the 3′-untranslated region of the thymidylate synthase gene and sensitivity of stomach cancer to fluoropyrimidine-based chemotherapy

Application and optimization of CRISPR–Cas9-mediated genome engineering in axolotl (Ambystoma mexicanum)

A scATAC-seq atlas of chromatin accessibility in axolotl brain regions

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