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Staphylococcus aureus adapts to diverse host environments during infection. Here, the authors use transposon sequencing to reveal niche-specific genes and identify 27 core genes required for S. aureus fitness across intracellular, blood, and organ niches.

The improvement of the thermoelectric figure of merit ZT has been hindered by the challenges associated with the independent control of the electrical and thermal conductivity. Here the authors show that SnS₂nanosheets can lead to an increased ZT via negative correlation between electrical and thermal conductivity.

Single atomic layers of transition metal dichalcogenides have outstanding electrical and optical properties. Here, the authors show that light absorption and emission from stacks of different transition metal dichalcogenide monolayers can be tuned by rotating the crystals.

Carrier injection from a metallic electrode into an oxide insulator component is made difficult by the large energy level offset between the two. Here, the authors show that an intermediary zinc-oxide layer enables an Ohmic electrical contact between a metal and an oxide insulator layer.

Animals detect microbiomes through smell, aiding communication, group recognition, and behavior. Here with Drosophila model, the authors show that airway and gut cells can sense microbiome-emitted scents independently of smell, promoting host growth.

Cubosomes, cubic-phase lipid nanoparticles, are of interest for delivery application but have failed in the delivery of long RNA. Here, the authors report on a premixing strategy which allows for the loading of long RNA into cubosomes with the advantage of consistent delivery after room temperature storage.

Monolithic 3D integration of electronics based on fully 2D materials is demonstrated in the performance of artificial intelligence tasks.

The arthropod head is complex and its evolution has been difficult to reconstruct. Here, Park et al. describe new specimens of the Cambrian stem-group euarthropod Kerygmachela that preserve evidence of primitive compound eyes and a unipartite brain, providing insight into the structure of the early arthropod head.

A gold-embedded oxide interlayer can be used to create metal–interlayer–semiconductor contacts for two-dimensional materials that exhibit low series resistance and Fermi level depinning.

Human activities release huge amounts of CO2 into the atmosphere, and much of this is soaked up by the oceans, hence regulating the global carbon cycle. These processes are driven by various physical and biogeochemical factors, which are expected to change under ongoing climate change. Therefore, the social cost of climate change mitigation substantially depends on how climate change modulates ocean CO₂ uptake.

A non-contact wearable device that defines and modulates a microclimate adjacent to the skin can measure incoming and outgoing streams of vapourized substances, offering valuable insights into physiological health, wound healing and environmental exposures.

By using optoelectronic device arrays for chip-to-chip communication and neuromorphic cores based on memristor crossbar arrays for highly parallel data processing, reconfigurable and stackable hetero-integrated chips can be created for use in edge computing applications.

We report full-colour, vertically stacked µLEDs that achieve exceptionally high array density (5,100 pixels per inch) and small size (4 µm) via a 2D material-based layer transfer technique, allowing the creation of full-colour µLED displays for augmented and virtual reality.

Proprotein convertase subtilisin/kexin type-9 (PCSK9) binds to and degrades low-density lipoprotein (LDL) receptor, leading to an increase of LDL cholesterol in blood. Here the authors show that PCSK9 itself directly induces inflammation and aggravates atherosclerosis independently of the LDL receptor.

Thermoelectric materials, which can convert heat into electricity, are of great interest for energy sustainability. The problem is the low efficiency of these materials, quantified by a coefficient, ZT, which for mid-temperature materials is usually around 1. The realization of a material, In₄Se_3–δ, which achieves the ZT value of 1.48 at 705 K, could open up a new avenue in the research to generate high ZT materials.

An integrated electronic platform with site-specific sensitivity is highly needed for medical applications. Here, Kim et al.report a stretchable prosthetic skin composed of ultrathin single crystalline silicon nanoribbon array, which can sense strain, pressure and temperature spontaneously.

In Drosophila, an amino acid deficit triggers the expression of the neuropeptide CNMamide in gut enterocytes, which promotes a compensatory appetite for essential over non-essential amino acids, and this process is modulated by the microbiome.

Electrically biased suspended graphene devices show an intense electroluminescence in the visible range with a tunable emission spectrum.

Cracking in thin films is usually associated with failure. Here, the authors use an electron beam to selectively irradiate a copper thin film on a polymer substrate and introduce designed cracks under tension to make a strain responsive organic light-emitting device (OLED).

The Hippo pathway plays a role in regulating organ size and stem cell renewal but the regulatory mechanisms that fine-tune this pathway are not well understood. Here the authors report on the role of NEDD4 as a negative regulator of the Hippo signalling components, WW45 and LATS kinase, and in controlling cell proliferation and intestinal stem cell homeostasis.

The integration of flexible electronics with conventional devices has been hampered by the lack of suitable soldering techniques able to withstand stretching. Jeonget al. use a porous substrate to fabricate biocompatible, stretchable electronics that can be interfaced with commercial components.

Splicing dysfunction has been observed in Alzheimer’s disease but it remains unclear whether splicing defects have a causal role. Here the authors generate a mouse model with perturbed U1 snRNP activity, recapitulating RNA splicing defects, neuron hyperexcitability, neurodegeneration and synergy with the amyloid cascade when crossed with 5xFAD mice.

The formation of blood vessels in tumours, angiogenesis, is a promising target for therapy. Here, the authors show that microRNA192 has anti-angiogenic functions and negatively regulates EGR1 and HOXB9, and that delivery of this microRNA to tumours in vivocan reduce angiogenesis and tumour growth.

Short interfering siRNAs—siRNAs—have therapeutic potential in the treatment of disease; however, their delivery to target tissues is difficult. Here, Wu et al. chemically modify siRNAs and show that this improves loading into the siRNA silencing machinery and thus efficacy in eliminating cancer cells in mice.

Muscle atrophy is associated with ageing, but the underlying molecular mechanisms are not well understood. Here, they authors show that ablation of the E3 ubiquitin ligase Mib1 is important for myofibre maintenance via a mechanism that involves targeting and degradation of Actn3, and that Mib1 ablation in mice induces muscle atrophy which can be rescued by knockown of Actn3 expression.