Copy number alterations occur frequently in patients with triple-negative breast cancer. Here, the authors identify copy number amplification of the role of FAD synthase enzyme (FLAD1) in TNBC and mechanistically demonstrate that this amplification drives tumorigenesis by increasing lipid metabolism via a FLAD1/LSD1/SREBP1 axis.
- Xiao-Qing Song
- Tian-Jian Yu
- Yi Xiao
