Nature Search

Large-scale serum N-glycomics tracks N-glycosylation dynamics in hepatocellular carcinoma progression and enables early diagnosis

Circulating N-glycomics studies have shown alterations in multiple cancer types. Here, the authors show that blood-based glycome patterns on proteins can be used to predict liver damage and liver cancer development.

Bin Fu
Jierong Chen
Haojie Lu
ResearchOpen Access20 Jan 2026
Nature Communications

Volume: 17, P: 1-16
A benchmark of expert-level academic questions to assess AI capabilities

Humanity’s Last Exam, a multi-modal benchmark at the frontier of human knowledge, is designed to be an expert-level closed-ended academic benchmark with broad subject coverage.

Long Phan
Alice Gatti
Davide Scaramuzza
ResearchOpen Access28 Jan 2026
Nature

Volume: 649, P: 1139-1146
JMJD2 regulates enhancer–promoter interactions via biomolecular condensate formation

This study presents LoopID, which profiles proteins at targeted interacting enhancer–promoter (E-P) pairs, identifying the histone demethylase JMJD2 as a regulator of E-P interactions through biomolecular condensate formation independent of its catalytic activity.

Shaoshuai Jiang
Xinyi Liu
Junjun Ding
Research16 Dec 2025
Nature Genetics

P: 1-14
Cobalt-catalyzed hydrothiolation of alkynes for the diverse synthesis of branched alkenyl sulfides

Branched alkenyl sulfides are useful moieties in synthesis and materials. Here, the authors disclose a hydromethylthiolation of alkynes via cobalt hydride catalysis, resulting in Markovnikov regioselectivity, proceeding via electrophilic thiolation.

Jiale Ying
Yan Tan
Zhan Lu
ResearchOpen Access14 Sept 2024
Nature Communications

Volume: 15, P: 1-9
Polarization-sensitive neuromorphic vision sensing enabled by pristine black arsenic-phosphorus

An anisotropic b-As_0.2P_0.8 phototransistor enables polarization-tunable synaptic behaviors with 4.7 polarization ratio, achieving >90% classification accuracy and high-fidelity polarization imaging through Stokes parameter reconstruction and DoLP mapping.

Shi Zhang
Shuguang Zhu
Xiaoshuang Chen
ResearchOpen Access02 Feb 2026
Light: Science & Applications

Volume: 15, P: 1-14
Lymph nodes molecular subtypes unravel lymph nodes heterogeneity and clinical implications in colorectal cancer

Lymph nodes are primarily categorised into metastatic and non-metastatic. Here, the authors perform integrated bulk and single-cell RNA sequencing on lymph nodes from 200 patients with colorectal cancer and identify 4 non-metastatic lymph node subtypes.

Xu Guan
Yueyang Zhang
Xishan Wang
ResearchOpen Access22 Aug 2025
Nature Communications

Volume: 16, P: 1-15
Sensing ceramides by CYSLTR2 and P2RY6 to aggravate atherosclerosis

CYSLTR2 and P2RY6 are identified as endogenous ceramide receptors, and inhibition of these ameliorates atherosclerosis, particularly in chronic-kidney-disease-associated cardiovascular disease.

Siting Zhang
Hui Lin
Wei Kong
Research06 Mar 2025
Nature

Volume: 641, P: 476-485
Internally hollow Cu₂O nanoframes with the abundance of {110} facets enhance direct propylene epoxidation

Achieving selective propylene epoxidation with molecular oxygen is a highly sought-after yet difficult objective. Here, the authors present a novel approach involving ligand protection and selective facet etching to synthesize internally hollow Cu₂O nanoframes, which exhibit outstanding catalytic activity for the reaction.

Yueming Qiu
Yichen Zhang
Jiale Huang
ResearchOpen Access21 Aug 2025
Nature Communications

Volume: 16, P: 1-12
Visual feature-based multi-scale hybrid attention network for fine-grained Hawthorn varieties identification

Chaoqun Tan
Jiale Deng
Li Ke
ResearchOpen Access22 Oct 2025
Scientific Reports

Volume: 15, P: 1-19
Explicit solutions of the generalized Kudryashov’s equation with truncated M-fractional derivative

Musong Gu
Fanming Liu
Zhao Li
ResearchOpen Access17 Sept 2024
Scientific Reports

Volume: 14, P: 1-9
Phase regulation enabling dense polymer-based composite electrolytes for solid-state lithium metal batteries

Polymer electrolytes based on poly(vinylidene fluoride) with residual solvents are appealing for room-temperature battery operations. Here, the authors present a phase regulation approach to achieve a dense electrolyte and enhance ionic conductivity through the incorporation of MoSe₂ sheets.

Qian Wu
Mandi Fang
Yingying Lu
ResearchOpen Access09 Oct 2023
Nature Communications

Volume: 14, P: 1-11
Single-phase local-high-concentration solid polymer electrolytes for lithium-metal batteries

Batteries with solid polymer electrolytes face challenges in electrochemical stability and compatibility with high-voltage cathodes. Chunsheng Wang and colleagues have developed a polymer blend with a high Li salt concentration that enhances the stability of solid polymer electrolytes and achieves promising electrochemical performance in full-cell applications.

Weiran Zhang
Volodymyr Koverga
Chunsheng Wang
Research12 Jan 2024
Nature Energy

Volume: 9, P: 386-400
Cryo-EM analysis of the HCoV-229E spike glycoprotein reveals dynamic prefusion conformational changes

The spike protein of coronaviruses (S-protein) is an envelope-anchored trimeric type I transmembrane glycoprotein that mediates receptor binding and the fusion of the viral and host cell membranes. Here the authors report the conformational states of HCoV-229E S trimer and observe the conformational changes in S1 subunit from closed state to activated state for receptor binding.

Xiyong Song
Yuejun Shi
Guiqing Peng
ResearchOpen Access08 Jan 2021
Nature Communications

Volume: 12, P: 1-9
Simultaneous profiling of chromatin architecture and transcription in single cells

Here the authors develop a single-cell multiomics sequencing method (scCARE-seq), which allows the simultaneous probing of 3D chromatin architecture and transcription for single cells. Using scCARE-seq they explore the relationship between the 3D genome and transcriptome in cell fate transitions and the cell cycle.

Jiale Qu
Jun Sun
Junjun Ding
Research14 Aug 2023
Nature Structural & Molecular Biology

Volume: 30, P: 1393-1402
Association between street greenery and physical activity among Chinese older adults in Beijing, China

Yiling Song
Mingzhong Zhou
Hongjun Yu
ResearchOpen Access04 Jun 2025
Scientific Reports

Volume: 15, P: 1-10
Physical activity moderates the mediating role of depression between experiential avoidance and Internet addiction

Jiale Wang
Li Tang
Shiju Zhu
ResearchOpen Access01 Jul 2025
Scientific Reports

Volume: 15, P: 1-13
A positive feedback loop between SERPINH1 and MMP-9/TGF-β1 promotes lung adenocarcinoma progression

Yang Zhou
Xueying Wang
Fang Liu
Research16 Aug 2025
Cell Death & Differentiation

Volume: 33, P: 140-155
Research on domain ontology construction based on the content features of online rumors

Jianbo Zhao
Huailiang Liu
Ruiyu Ding
ResearchOpen Access27 May 2024
Scientific Reports

Volume: 14, P: 1-21
Achievements, challenges, and future prospects for industrialization of perovskite solar cells

This review summarized the challenges in the industrialization of perovskite solar cells (PSCs), encompassing technological limitations, multi-scenario applications, and sustainable development. Additionally, the focus of future advancements in PSCs was discussed.

Chuang Yang
Wenjing Hu
Hongwei Han
ReviewsOpen Access03 Sept 2024
Light: Science & Applications

Volume: 13, P: 1-48

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