Nature Search

Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus

Xuejun Zhang and colleagues report results of a genome-wide association study of systemic lupus erythematosus (SLE) in a Chinese Han population. Their work identifies nine new SLE susceptibility loci and reveals overlap in the spectrum of risk alleles shared between Chinese Han and European populations.

Jian-Wen Han
Hou-Feng Zheng
Xue-Jun Zhang
Research18 Oct 2009
Nature Genetics

Volume: 41, P: 1234-1237
Angiotensin-Converting Enzyme Gene 2350 G/A Polymorphism Is Associated with Left Ventricular Hypertrophy but Not Essential Hypertension

Min Pan
Jian-Hua Zhu
Xiang-Jun Yang
Research01 Jan 2007
Hypertension Research

Volume: 30, P: 31-37
Association analyses identify six new psoriasis susceptibility loci in the Chinese population

Xue-Jun Zhang and colleagues report genome-wide association analyses identifying six new susceptibility loci in the Chinese population.

Liang-Dan Sun
Hui Cheng
Xue-Jun Zhang
Research17 Oct 2010
Nature Genetics

Volume: 42, P: 1005-1009
Prognostic nomogram for recurrence of hepatocellular carcinoma after liver transplantation for decision making on postoperative adjuvant therapy

Chen-Hao Gao
Qi-Jian Yu
Zhe Yang
ResearchOpen Access23 Jul 2025
Scientific Reports

Volume: 15, P: 1-11
Nutritional status and daily habits as determinants of hospitalization duration in ovarian cancer patients undergoing chemotherapy

Xin Dan
Ya-Lin Tian
Jian-Hua Ren
ResearchOpen Access13 Nov 2024
Scientific Reports

Volume: 14, P: 1-13
Structure-based drug design of a novel family of chalcones as PPARα agonists: virtual screening, synthesis, and biological activities in vitro

Xiang-hua Li
Han-jun Zou
Jian-hua Shen
Research01 Dec 2007
Acta Pharmacologica Sinica

Volume: 28, P: 2040-2052
Microbe-induced gene silencing boosts crop protection against soil-borne fungal pathogens

This study develops a microbe-induced gene silencing technology by constructing an RNAi engineering microbe to prove the existence of interspecies RNAi in rhizospheric fungi and demonstrate its application in crop protection against fungal pathogens.

Han-Guang Wen
Jian-Hua Zhao
Hui-Shan Guo
Research31 Aug 2023
Nature Plants

Volume: 9, P: 1409-1418
Pro-CRISPR PcrIIC1-associated Cas9 system for enhanced bacterial immunity

Comprehensive analyses of Cas9 proteins shed light on the evolution of the CRISPR–Cas9 system, and identify a pro-CRISPR accessory protein in bacteria that boosts CRISPR-mediated immunity by enhancing the DNA binding and cleavage activity of Cas9.

Shouyue Zhang
Ao Sun
Jun-Jie Gogo Liu
Research29 May 2024
Nature

Volume: 630, P: 484-492
The extracellular domain of Staphylococcus aureus LtaS binds insulin and induces insulin resistance during infection

The extracellular domain of the cell wall protein LtaS is an insulin-binding protein and mediates insulin resistance during Staphylococcus aureus infection.

Yu Liu
Fang-Jie Liu
Guang Yang
Research16 Apr 2018
Nature Microbiology

Volume: 3, P: 622-631
Abrogating ClC-3 Inhibits LPS-induced Inflammation via Blocking the TLR4/NF-κB Pathway

Nan-lin Xiang
Jun Liu
Jian-hua Zhang
ResearchOpen Access01 Jul 2016
Scientific Reports

Volume: 6, P: 1-10
Body distribution and in situ evading of phagocytic uptake by macrophages of long-circulating poly (ethylene glycol) cyanoacrylate-co-n-hexadecyl cyanoacrylate nanoparticles

Min Huang
Wei Wu
Jian-hua Zhu
Research01 Dec 2005
Acta Pharmacologica Sinica

Volume: 26, P: 1512-1518
Integration of transcriptomic and proteomic data uncovers the nutritional requirement of the immature development of an endoparasitoid wasp

Li-Zhi Wang
Zi-Han Wang
Xue-Xin Chen
ResearchOpen Access22 May 2025
Scientific Reports

Volume: 15, P: 1-11
Comprehensive Assessment of the Association of WNK4 Polymorphisms with Hypertension: Evidence from a Meta-Analysis

Xiao-gang Guo
Jie Ding
Liang-rong Zheng
ResearchOpen Access30 Sept 2014
Scientific Reports

Volume: 4, P: 1-10
Research on fault diagnosis method of planetary gearbox based on dynamic simulation and deep transfer learning

Meng-Meng Song
Zi-Cheng Xiong
Yao-Hong Tang
ResearchOpen Access11 Oct 2022
Scientific Reports

Volume: 12, P: 1-15
Protective effects of iptakalim, a novel ATP-sensitive potassium channel opener, on global cerebral ischemia-evoked insult in gerbils

Hua Chen
Yong Yang
Gang Hu
Research01 Jun 2006
Acta Pharmacologica Sinica

Volume: 27, P: 665-672
Experiments with levitated force sensor challenge theories of dark energy

In experiments with a levitated force sensor, no signatures of a fifth force are detected. This rules out the basic chameleon model, which is a popular theory providing an explanation for dark energy.

Peiran Yin
Rui Li
Jiangfeng Du
Research25 Aug 2022
Nature Physics

Volume: 18, P: 1181-1185
Tumor distribution affects bladder recurrence but not survival outcome of multifocal upper tract urothelial carcinoma treated with radical nephroureterectomy

Zai-Lin Sheu
Chi-Ping Huang
Hsin‑Chih Yeh
ResearchOpen Access24 Sept 2021
Scientific Reports

Volume: 11, P: 1-10
Preliminary study on pathogenesis of bronchial asthma in children

Ya-Feng Ren
Hong Li
Jian-Hua Zhang
Research13 Jan 2015
Pediatric Research

Volume: 77, P: 506-510
Gefitinib (an EGFR tyrosine kinase inhibitor) plus anlotinib (an multikinase inhibitor) for untreated, EGFR-mutated, advanced non-small cell lung cancer (FL-ALTER): a multicenter phase III trial

Hua-Qiang Zhou
Ya-Xiong Zhang
Wen-Feng Fang
ResearchOpen Access13 Aug 2024
Signal Transduction and Targeted Therapy

Volume: 9, P: 1-12
Single-cell transcriptomics reveals regulators underlying immune cell diversity and immune subtypes associated with prognosis in nasopharyngeal carcinoma

Yu-Pei Chen
Jian-Hua Yin
Jun Ma
ResearchOpen Access20 Jul 2020
Cell Research

Volume: 30, P: 1024-1042
MTHFR polymorphisms, dietary folate intake and breast cancer risk in Chinese women

Chang-Ming Gao
Jin-Hai Tang
Kazuo Tajima
Research26 Jun 2009
Journal of Human Genetics

Volume: 54, P: 414-418
Chord: an ensemble machine learning algorithm to identify doublets in single-cell RNA sequencing data

For the unmet need to choose the suitable doublet detection method, an ensemble machine learning algorithm called Chord was developed, which integrates multiple methods and achieves higher accuracy and stability on different scRNA-seq datasets.

Ke-Xu Xiong
Han-Lin Zhou
Gui-Bo Li
ResearchOpen Access30 May 2022
Communications Biology

Volume: 5, P: 1-11
JMJD3 promotes esophageal squamous cell carcinoma pathogenesis through epigenetic regulation of MYC

Shu-Man Li
Li-Ru He
Dan Xie
ResearchOpen Access25 Aug 2020
Signal Transduction and Targeted Therapy

Volume: 5, P: 1-3
Comprehensive transcriptome profiling of Taiwanese colorectal cancer implicates an ethnic basis for pathogenesis

Shao-Min Wu
Wen-Sy Tsai
Hsuan Liu
ResearchOpen Access11 Mar 2020
Scientific Reports

Volume: 10, P: 1-18
TGR5 agonist inhibits intestinal epithelial cell apoptosis via cAMP/PKA/c-FLIP/JNK signaling pathway and ameliorates dextran sulfate sodium-induced ulcerative colitis

Wen-ji Yang
Fang-hui Han
Ying Leng
Research30 Mar 2023
Acta Pharmacologica Sinica

Volume: 44, P: 1649-1664
Effect of different courses and durations of invasive mechanical ventilation on respiratory outcomes in very low birth weight infants

Yang Yang
Xin-yue Gu
Joseph Ting
ResearchOpen Access03 Nov 2023
Scientific Reports

Volume: 13, P: 1-8
Circular RNA AFF4 modulates osteogenic differentiation in BM-MSCs by activating SMAD1/5 pathway through miR-135a-5p/FNDC5/Irisin axis

Chao Liu
An-Song Liu
Ke Yin
ResearchOpen Access18 Jun 2021
Cell Death & Disease

Volume: 12, P: 1-17
Prevalence of monoclonal gammopathy of undetermined significance in a large population with annual medical check-ups in China

Jian-hua Han
Ji-nuo Wang
Jian Li
CorrespondenceOpen Access09 Mar 2020
Blood Cancer Journal

Volume: 10, P: 1-4
MiR-30e inhibits tumor growth and chemoresistance via targeting IRS1 in Breast Cancer

Min-min Liu
Zhi Li
Lin-lin Zhen
ResearchOpen Access21 Nov 2017
Scientific Reports

Volume: 7, P: 1-10
Poria cocos: traditional uses, triterpenoid components and their renoprotective pharmacology

Zhi-yuan Guo
Xin Wu
Ying-yong Zhao
Reviews31 Oct 2024
Acta Pharmacologica Sinica

Volume: 46, P: 836-851
Requirement of AQP4 for Antidepressive Efficiency of Fluoxetine: Implication in Adult Hippocampal Neurogenesis

Hui Kong
Luo-lin Sha
Gang Hu
Research15 Oct 2008
Neuropsychopharmacology

Volume: 34, P: 1263-1276
The emerging treatment landscape of targeted therapy in non-small-cell lung cancer

Min Yuan
Li-Li Huang
Qing Xu
ReviewsOpen Access17 Dec 2019
Signal Transduction and Targeted Therapy

Volume: 4, P: 1-14

Search

Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus

Angiotensin-Converting Enzyme Gene 2350 G/A Polymorphism Is Associated with Left Ventricular Hypertrophy but Not Essential Hypertension

Association analyses identify six new psoriasis susceptibility loci in the Chinese population

Prognostic nomogram for recurrence of hepatocellular carcinoma after liver transplantation for decision making on postoperative adjuvant therapy

Nutritional status and daily habits as determinants of hospitalization duration in ovarian cancer patients undergoing chemotherapy

Structure-based drug design of a novel family of chalcones as PPARα agonists: virtual screening, synthesis, and biological activities in vitro

Microbe-induced gene silencing boosts crop protection against soil-borne fungal pathogens

Pro-CRISPR PcrIIC1-associated Cas9 system for enhanced bacterial immunity

The extracellular domain of Staphylococcus aureus LtaS binds insulin and induces insulin resistance during infection

Abrogating ClC-3 Inhibits LPS-induced Inflammation via Blocking the TLR4/NF-κB Pathway

Body distribution and in situ evading of phagocytic uptake by macrophages of long-circulating poly (ethylene glycol) cyanoacrylate-co-n-hexadecyl cyanoacrylate nanoparticles

Integration of transcriptomic and proteomic data uncovers the nutritional requirement of the immature development of an endoparasitoid wasp

Comprehensive Assessment of the Association of WNK4 Polymorphisms with Hypertension: Evidence from a Meta-Analysis

Research on fault diagnosis method of planetary gearbox based on dynamic simulation and deep transfer learning

Protective effects of iptakalim, a novel ATP-sensitive potassium channel opener, on global cerebral ischemia-evoked insult in gerbils

Experiments with levitated force sensor challenge theories of dark energy

Tumor distribution affects bladder recurrence but not survival outcome of multifocal upper tract urothelial carcinoma treated with radical nephroureterectomy

Preliminary study on pathogenesis of bronchial asthma in children

Gefitinib (an EGFR tyrosine kinase inhibitor) plus anlotinib (an multikinase inhibitor) for untreated, EGFR-mutated, advanced non-small cell lung cancer (FL-ALTER): a multicenter phase III trial

Single-cell transcriptomics reveals regulators underlying immune cell diversity and immune subtypes associated with prognosis in nasopharyngeal carcinoma

MTHFR polymorphisms, dietary folate intake and breast cancer risk in Chinese women

Chord: an ensemble machine learning algorithm to identify doublets in single-cell RNA sequencing data

JMJD3 promotes esophageal squamous cell carcinoma pathogenesis through epigenetic regulation of MYC

Comprehensive transcriptome profiling of Taiwanese colorectal cancer implicates an ethnic basis for pathogenesis

TGR5 agonist inhibits intestinal epithelial cell apoptosis via cAMP/PKA/c-FLIP/JNK signaling pathway and ameliorates dextran sulfate sodium-induced ulcerative colitis

Effect of different courses and durations of invasive mechanical ventilation on respiratory outcomes in very low birth weight infants

Circular RNA AFF4 modulates osteogenic differentiation in BM-MSCs by activating SMAD1/5 pathway through miR-135a-5p/FNDC5/Irisin axis

Prevalence of monoclonal gammopathy of undetermined significance in a large population with annual medical check-ups in China

MiR-30e inhibits tumor growth and chemoresistance via targeting IRS1 in Breast Cancer

Poria cocos: traditional uses, triterpenoid components and their renoprotective pharmacology

Requirement of AQP4 for Antidepressive Efficiency of Fluoxetine: Implication in Adult Hippocampal Neurogenesis

The emerging treatment landscape of targeted therapy in non-small-cell lung cancer

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