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Nature Microbiology (1)

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Amino acid changes in two viral proteins drive attenuation of the yellow fever 17D vaccine

Amino acid changes in the envelope and non-structural 2A protein attenuate the virulent yellow fever virus (YFV) and enhance host antiviral responses upon infection in vivo. These traits explain the potency of the YFV vaccine.

Jiayu Zhang
Elizabeth C. Chavez
Alexander Ploss
ResearchOpen Access08 Jul 2025
Nature Microbiology

Volume: 10, P: 1902-1917

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Amino acid changes in two viral proteins drive attenuation of the yellow fever 17D vaccine

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