Nature Search

Author Correction: Micropillar arrays as a high-throughput screening platform for therapeutics in multiple sclerosis

Feng Mei
Stephen P J Fancy
Jonah R Chan
Amendments and Corrections12 Jul 2024
Nature Medicine

Volume: 30, P: 2692
Connexin43 hemichannel blockade turns microglia neuroprotective and mitigates cognitive deficits in a mouse model of amyloidosis

Microglia play a critical role in Alzheimer’s disease progression. Here, the authors show that knockout of microglial Cx43 or inhibition of Cx43 hemichannels by nanoparticle-delivered peptide mitigates cognitive deficits and neuropathology in APP/PS1 mice by inducing microglia into a neuroprotective state.

Yixun Su
Hui Li
Chenju Yi
ResearchOpen Access01 Jul 2025
Nature Communications

Volume: 16, P: 1-20
Oligodendrocyte precursor cells facilitate neuronal lysosome release

Oligodendrocyte precursor cells (OPCs) play a multifaceted role in the brain. Here, the authors show that OPCs regulate neuronal metabolism by forming contacts with neuronal somata, facilitating lysosomal release from neurons.

Li-Pao Fang
Ching-Hsin Lin
Xianshu Bai
ResearchOpen Access30 Jan 2025
Nature Communications

Volume: 16, P: 1-10
Genome sequence of the model medicinal mushroom Ganoderma lucidum

Ganoderma lucidumis a macrofungus in traditional Chinese medicine known to produce different bioactive compounds. In this study, the genome ofG. lucidumis sequenced, making this organism a potential model system for future studies of secondary metabolic pathways and their regulation in medicinal fungi.

Shilin Chen
Jiang Xu
Chao Sun
ResearchOpen Access26 Jun 2012
Nature Communications

Volume: 3, P: 1-9
Aberrant oligodendroglial–vascular interactions disrupt the blood–brain barrier, triggering CNS inflammation

The authors report aberrant oligodendrocyte precursor cell (OPC) interactions with blood vessels in certain multiple sclerosis lesions. These clustered OPCs can disrupt the blood–brain barrier and can impair OPC recruitment to repairing lesions.

Jianqin Niu
Hui-Hsin Tsai
Stephen P. J. Fancy
Research15 Apr 2019
Nature Neuroscience

Volume: 22, P: 709-718
Lgl1 controls NG2 endocytic pathway to regulate oligodendrocyte differentiation and asymmetric cell division and gliomagenesis

Oligodendrocyte progenitor cells (OPCs) undergo asymmetric cell division, and disruption of such mechanism can generate oligodendroglioma precursors. Here, Daynac and colleagues show that Lgl1 regulates asymmetric division and differentiation of OPCs by interfering with the endocytosis pathway, and that Lgl1 knockout can lead to gliomagenesis.

Mathieu Daynac
Malek Chouchane
Claudia K. Petritsch
ResearchOpen Access21 Aug 2018
Nature Communications

Volume: 9, P: 1-15
Micropillar arrays as a high-throughput screening platform for therapeutics in multiple sclerosis

High-throughput screening platform for the testing of small bioactive molecules that promote oligodendrocyte differentiation and remyelination: a new path to the discovery of potential drugs for multiple sclerosis.

Feng Mei
Stephen P J Fancy
Jonah R Chan
Research06 Jul 2014
Nature Medicine

Volume: 20, P: 954-960
Critical analysis of translational potential of rodent models of white matter pathology across a wide spectrum of human diseases

Wenxuan Zhou
Shiyue Xia
Jianqin Niu
ReviewsOpen Access31 Jul 2025
Cell Death & Disease

Volume: 16, P: 1-26
Pathological oligodendrocyte precursor cells revealed in human schizophrenic brains and trigger schizophrenia-like behaviors and synaptic defects in genetic animal model

Guangdan Yu
Yixun Su
Jianqin Niu
ResearchOpen Access21 Sept 2022
Molecular Psychiatry

Volume: 27, P: 5154-5166

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Author Correction: Micropillar arrays as a high-throughput screening platform for therapeutics in multiple sclerosis

Connexin43 hemichannel blockade turns microglia neuroprotective and mitigates cognitive deficits in a mouse model of amyloidosis

Oligodendrocyte precursor cells facilitate neuronal lysosome release

Genome sequence of the model medicinal mushroom Ganoderma lucidum

Aberrant oligodendroglial–vascular interactions disrupt the blood–brain barrier, triggering CNS inflammation

Lgl1 controls NG2 endocytic pathway to regulate oligodendrocyte differentiation and asymmetric cell division and gliomagenesis

Micropillar arrays as a high-throughput screening platform for therapeutics in multiple sclerosis

Critical analysis of translational potential of rodent models of white matter pathology across a wide spectrum of human diseases

Pathological oligodendrocyte precursor cells revealed in human schizophrenic brains and trigger schizophrenia-like behaviors and synaptic defects in genetic animal model

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