Clear cell renal cell carcinoma (ccRCC) is characterized by activation of hypoxia-inducible factors and enhanced aerobic glycolysis. In this study, the authors found that ccRCC maintains high levels of fructose-1,6-bisphosphate (FBP) through the downregulation of aldolase B. In turn, FBP regulates the redox status of the tumor by suppressing NADPH oxidase isoform NOX4 activity. Thus, aldolase B and FBP are critical regulators of reactive oxygen species and contribute to tumor progression.
