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Showing 1–50 of 51 results

Advanced filters: Author: Jianxing Zhang Clear advanced filters

"Dark Mediators" of Proteins as Revealed by NMR in Water: Residue-selective Anion Bindings that are Masked by Pre-existing Buffer

Jianxing Song
Linlin Miao
Haina Qin
ResearchOpen Access10 Jan 2012
Nature Precedings

P: 1
Pig-to-human lung xenotransplantation into a brain-dead recipient

In this attempt at xenotransplantation of a lung from a genetically modified pig into a brain-dead recipient, although the grafted lung initially maintained viability and functionality, antibody-mediated rejection rapidly occurred, contributing to xenograft damage.

Jianxing He
Jiang Shi
Xin Xu
Research25 Aug 2025
Nature Medicine

Volume: 31, P: 3388-3393
Astrocytic pleiotrophin deficiency in the prefrontal cortex contributes to stress-induced depressive-like responses in male mice

Astrocytes in the prefrontal cortex are closely linked to depression, but the underlying mechanisms remain unclear. Here, the authors show that reduction of astrocytic pleiotrophin in the dorsomedial prefrontal cortex contributes to depression-like phenotype in male mice.

Dongmei Chi
Kun Zhang
Handong Ouyang
ResearchOpen Access14 Mar 2025
Nature Communications

Volume: 16, P: 1-19
Atezolizumab plus bevacizumab and chemotherapy in metastatic nonsquamous NSCLC: the randomized double-blind phase 3 IMpower151 trial

In the IMpower151 trial, the drug combination previously shown to be effective in the IMpower150 trial was not significantly effective in a Chinese population.

Caicun Zhou
Xiaorong Dong
Minu K. Srivastava
ResearchOpen Access16 May 2025
Nature Medicine

Volume: 31, P: 2375-2384
Room-temperature continuous-wave lasing from monolayer molybdenum ditelluride integrated with a silicon nanobeam cavity

A silicon nanobeam cavity laser integrated with monolayer molybdenum ditelluride enables room-temperature lasing in the near infrared.

Yongzhuo Li
Jianxing Zhang
C. Z. Ning
Research17 Jul 2017
Nature Nanotechnology

Volume: 12, P: 987-992
Changing patterns of global nitrogen deposition driven by socio-economic development

Zhu et al. compile a global N deposition database and find a shift in N deposition, with developing countries emerging as new hotspots. A strong link between economic development and N dynamics is identified, with important policy implications.

Jianxing Zhu
Yanlong Jia
Peter Vitousek
ResearchOpen Access02 Jan 2025
Nature Communications

Volume: 16, P: 1-10
Early triage of critically ill COVID-19 patients using deep learning

The sudden deterioration of patients with novel coronavirus disease 2019 (COVID-19) into critical illness is of major concern and early assessment would be vital. Here, the authors show that a deep learning-based survival model can predict the risk of COVID-19 patients developing critical illness based on clinical characteristics at admission.

Wenhua Liang
Jianhua Yao
Jianxing He
ResearchOpen Access15 Jul 2020
Nature Communications

Volume: 11, P: 1-7
A programmable and self-adaptive ultrasonic wireless implant for personalized chronic pain management

An implantable ultrasound-induced wireless electrical stimulator and a machine learning-based pain classifier can generate programmable, closed-loop based self-adaptive electrical stimulation to the spinal cord to manage chronic pain.

Yushun Zeng
Chen Gong
Qifa Zhou
Research12 May 2025
Nature Electronics

Volume: 8, P: 437-449
Author Correction: Ultrasensitive detection of circulating tumour DNA via deep methylation sequencing aided by machine learning

Naixin Liang
Bingsi Li
Zhihong Zhang
Amendments and Corrections30 Sept 2021
Nature Biomedical Engineering

Volume: 5, P: 1402
Frequent alterations in cytoskeleton remodelling genes in primary and metastatic lung adenocarcinomas

Despite lung adenocarcinoma having a high global mortality, the genetic mutations present in Asian patients are uncharacterized. Here the authors use genomic and transcriptomic analysis to identify thirteen significantly affected genes, including RHPN2, GLI3, MRC2, TP53 and IQGAP3.

Kui Wu
Xin Zhang
Jianxing He
ResearchOpen Access09 Dec 2015
Nature Communications

Volume: 6, P: 1-13
A deep-learning pipeline for the diagnosis and discrimination of viral, non-viral and COVID-19 pneumonia from chest X-ray images

An automated deep-learning pipeline for chest-X-ray-image standardization, lesion visualization and disease diagnosis can identify viral pneumonia caused by COVID-19, assess its severity, and discriminate it from other types of pneumonia.

Guangyu Wang
Xiaohong Liu
Tianxin Lin
Research15 Apr 2021
Nature Biomedical Engineering

Volume: 5, P: 509-521
Nomogram for predicting early recurrence of hepatocellular carcinoma with narrow resection margin

Jinyu Zhang
Zhiping Wang
Jianxing Zeng
ResearchOpen Access15 Nov 2024
Scientific Reports

Volume: 14, P: 1-14
Hypoxanthine phosphoribosyl transferase 1 metabolizes temozolomide to activate AMPK for driving chemoresistance of glioblastomas

The metabolism of temozolomide (TMZ) to form methyldiazonium ions and 5-aminoimidazole-4-carboxamide (AICA) results in DNA damage, despite this, resistance frequently occurs in glioblastoma. Here, the authors demonstrate that AICA is further metabolised by HPRT1 into AICAR, which activates AMPK signalling and increases DNA damage repair. Targeting this axis in preclinical glioblastoma models sensitised tumours to TMZ.

Jianxing Yin
Xiefeng Wang
Xu Qian
ResearchOpen Access22 Sept 2023
Nature Communications

Volume: 14, P: 1-15
Climate and anthropogenic activities control spatiotemporal dynamics of topsoil inorganic carbon in China

Spatial variability of topsoil inorganic carbon is influenced by climate and soil properties, whereas nitrogen deposition, fertilizer-induced acidification, and reduced calcium supply contribute to the temporal trends, according to an analysis of 2526 soil samples across China from 1980 to 2020.

Qiongyu Zhang
Jianxing Zhu
Cong-Qiang Liu
ResearchOpen Access04 Aug 2025
Communications Earth & Environment

Volume: 6, P: 1-9
Circular RNA circGlis3 protects against islet β-cell dysfunction and apoptosis in obesity

Pancreatic β-cell compensation is a major mechanism in delaying T2DM progression. Here, the authors show that circGlis3 levels are affected by QKI and FUS expression, and that increasing circGlis3 lengthens β-cell compensation via enhancing insulin secretion and reducing apoptosis.

Yue Liu
Yue Yang
Liang Jin
ResearchOpen Access21 Jan 2023
Nature Communications

Volume: 14, P: 1-19
The use of double-mode RR Lyrae stars as robust distance and metallicity indicators

Analysis of a large sample of double-mode RR Lyrae stars shows that they are robust distance and metallicity indicators. Considering that the number of double-mode RR Lyr stars is comparable with that of classical Cepheids, they would be excellent distance tracers for older objects in the near-field universe.

Xiaodian Chen
Jianxing Zhang
Licai Deng
ResearchOpen Access19 Jun 2023
Nature Astronomy

Volume: 7, P: 1081-1089
The activity and immune dynamics of PD-1 inhibition on high-risk pulmonary ground glass opacity lesions: insights from a single-arm, phase II trial

Bo Cheng
Caichen Li
Wenhua Liang
ResearchOpen Access19 Apr 2024
Signal Transduction and Targeted Therapy

Volume: 9, P: 1-13
Author Correction: A deep-learning pipeline for the diagnosis and discrimination of viral, non-viral and COVID-19 pneumonia from chest X-ray images

Guangyu Wang
Xiaohong Liu
Tianxin Lin
Amendments and Corrections29 Jul 2021
Nature Biomedical Engineering

Volume: 5, P: 943
Reshaping transplantation with AI, emerging technologies and xenotransplantation

This Review discusses the scientific and technological breakthroughs reshaping transplant medicine, with a focus on the transformative role of artificial intelligence, xenotransplantation and tissue engineering as new sources of organs, and novel approaches to immunosuppression.

Alexandre Loupy
Evgenia Preka
Kang Zhang
Reviews14 Jul 2025
Nature Medicine

Volume: 31, P: 2161-2173
Long-term outcomes of Allium ureteral stent as a treatment for ureteral obstruction

Boxing Su
Weiguo Hu
Jianxing Li
ResearchOpen Access20 Sept 2024
Scientific Reports

Volume: 14, P: 1-7
Soft three-dimensional network materials with rational bio-mimetic designs

The development of artificial 3D soft materials and device systems that can reproduce the nonlinear, anisotropic mechanical properties of biological tissues remains challenging. Here, the authors design a class of soft 3D network materials that can offer defect-insensitive, nonlinear mechanical responses closely matched with those of biological tissues.

Dongjia Yan
Jiahui Chang
Yihui Zhang
ResearchOpen Access04 Mar 2020
Nature Communications

Volume: 11, P: 1-11
Ultrasensitive detection of circulating tumour DNA via deep methylation sequencing aided by machine learning

Deep methylation sequencing aided by a machine-learning classifier of methylation patterns enables the detection of early cancers from plasma samples at dilution factors as low as 1/10,000.

Naixin Liang
Bingsi Li
Zhihong Zhang
Research15 Jun 2021
Nature Biomedical Engineering

Volume: 5, P: 586-599
Bioinspired elastomer composites with programmed mechanical and electrical anisotropies

Many biological tissues exhibit directionally dependent properties. Here, authors develop tissue-like elastomer composites with programmed mechanical and electrical anisotropy and discuss potential applications in bioelectronics and humanoid artificial muscles.

Yun Ling
Wenbo Pang
Zheng Yan
ResearchOpen Access26 Jan 2022
Nature Communications

Volume: 13, P: 1-11
Asymmetric-waveform alternating current-promoted silver catalysis for C–H phosphorylation

Preventing metal deposition by cathodic reduction under direct current electrolysis conditions is a formidable challenge in transition-metal-catalysed electrosynthesis. Now, an asymmetric-waveform alternating current (a.c.) electrolysis approach is developed for silver-catalysed C–H phosphorylation where this a.c.-based approach regenerates the silver catalyst and keeps the catalyst loading balanced during the reaction.

Li Zeng
Ying Jiao
Aiwen Lei
Research05 Jan 2023
Nature Synthesis

Volume: 2, P: 172-181
Magnetic fabric from Red clay sediments in the Chinese Loess Plateau

Hujun Gong
Rui Zhang
Jianxing Li
ResearchOpen Access27 Apr 2015
Scientific Reports

Volume: 5, P: 1-6
Stabilization of atmospheric nitrogen deposition in China over the past decade

Nitrogen deposition in China has been almost constant over the past decade, as decreasing wet deposition has balanced increasing dry deposition, according to analyses of extensive datasets on wet and dry nitrogen depositions in China.

Guirui Yu
Yanlong Jia
Keith Goulding
Research22 Apr 2019
Nature Geoscience

Volume: 12, P: 424-429
ABO blood group system correlates with preoperative serum PSA level in patients with prostate cancer

Fangming Wang
Yan Zhang
Jianxing Li
ResearchOpen Access12 Mar 2025
Scientific Reports

Volume: 15, P: 1-9
Addendum: Early triage of critically ill COVID-19 patients using deep learning

Wenhua Liang
Jianhua Yao
Jianxing He
Amendments and CorrectionsOpen Access01 Feb 2021
Nature Communications

Volume: 12, P: 1-2
The practical implementation of artificial intelligence technologies in medicine

To bring the full potential of AI to the clinic, practical and regulatory changes need to be made in health systems globally.

Jianxing He
Sally L. Baxter
Kang Zhang
Reviews07 Jan 2019
Nature Medicine

Volume: 25, P: 30-36
High-speed and low-power molecular dynamics processing unit (MDPU) with ab initio accuracy

Pinghui Mo
Yujia Zhang
Jie Liu
ResearchOpen Access07 Nov 2024
npj Computational Materials

Volume: 10, P: 1-10
Mid-Miocene sea level altitude of the Qaidam Basin, northern Tibetan Plateau

The identification of marine alkenones and anomalously high carbonate carbon isotopic values in sediments suggest the Qaidam Basin in the northern Tibetan Plateau was uplifted from sea level to its present altitude since the Mid-Miocene.

Yuanyuan Sun
Yu Liang
Zhonghui Liu
ResearchOpen Access03 Jan 2023
Communications Earth & Environment

Volume: 4, P: 1-10
Publisher Correction: An open dataset for intelligent recognition and classification of abnormal condition in longwall mining

Wenjuan Yang
Xuhui Zhang
Dian Zhao
Amendments and CorrectionsOpen Access06 Aug 2024
Scientific Data

Volume: 11, P: 1
Containment of SARS-CoV-2 Delta strain in Guangzhou, China by quarantine and social distancing: a modelling study

Zhiqi Zeng
Tong Wu
Jianxing He
ResearchOpen Access06 Dec 2022
Scientific Reports

Volume: 12, P: 1-14
Selective activation of AKAP150/TRPV1 in ventrolateral periaqueductal gray GABAergic neurons facilitates conditioned place aversion in male mice

AKAP150 modulates TRPV1 phosphorylation in GABAergic, but not glutamatergic, neurons of the ventrolateral periaqueductal gray to control conditioned place aversion in male mice

Xiaohui Bai
Kun Zhang
Wan Huang
ResearchOpen Access17 Jul 2023
Communications Biology

Volume: 6, P: 1-11
Associations of Blood Pressure with the Factors among Adults in Jilin Province: A Cross-Sectional Study Using Quantile Regression Analysis

Junsen Ye
Zhongmin Li
Lina Jin
ResearchOpen Access19 Oct 2017
Scientific Reports

Volume: 7, P: 1-8
METTL3-mediated m6A modification of LINC00839 maintains glioma stem cells and radiation resistance by activating Wnt/β-catenin signaling

Jianxing Yin
Fangshu Ding
Xiefeng Wang
ResearchOpen Access12 Jul 2023
Cell Death & Disease

Volume: 14, P: 1-12
Toripalimab plus chemotherapy as second-line treatment in previously EGFR-TKI treated patients with EGFR-mutant-advanced NSCLC: a multicenter phase-II trial

Tao Jiang
Pingyang Wang
Shengxiang Ren
ResearchOpen Access15 Oct 2021
Signal Transduction and Targeted Therapy

Volume: 6, P: 1-9
The brain’s structural differences between postherpetic neuralgia and lower back pain

Jianxing Qiu
Mengjiao Du
Zhiguo Zhang
ResearchOpen Access17 Nov 2021
Scientific Reports

Volume: 11, P: 1-10
A study of the difference in biochemical metabolism between patients with unilateral and bilateral upper urinary tract stones

Zhibin Zheng
Weiguo Hu
Guojun Chen
ResearchOpen Access03 Dec 2024
Scientific Reports

Volume: 14, P: 1-9
Identifying ChIP-seq enrichment using MACS

Jianxing Feng
Tao Liu
Xiaole Shirley Liu
Protocols30 Aug 2012
Nature Protocols

Volume: 7, P: 1728-1740
CRISPR-powered optothermal nanotweezers: Diverse bio-nanoparticle manipulation and single nucleotide identification

We develop optothermal tweezers to boost CRISPR-based single-nucleotide polymorphism (SNP) detection at the single-molecule level. Additionally, this innovative approach has endowed optical tweezers with DNA identification ability.

Jiajie Chen
Zhi Chen
Yonghong Shao
ResearchOpen Access16 Nov 2023
Light: Science & Applications

Volume: 12, P: 1-11
Envonalkib versus crizotinib for treatment-naive ALK-positive non-small cell lung cancer: a randomized, multicenter, open-label, phase III trial

Yunpeng Yang
Jie Min
Wenfeng Fang
ResearchOpen Access14 Aug 2023
Signal Transduction and Targeted Therapy

Volume: 8, P: 1-8
Efficacy, safety and pharmacokinetics of Unecritinib (TQ-B3101) for patients with ROS1 positive advanced non-small cell lung cancer: a Phase I/II Trial

Shun Lu
Hongming Pan
Jiajia Zhu
ResearchOpen Access30 Jun 2023
Signal Transduction and Targeted Therapy

Volume: 8, P: 1-11
MAP kinase-interacting serine/threonine kinase 2 promotes proliferation, metastasis, and predicts poor prognosis in non-small cell lung cancer

Zhihua Guo
Guilin Peng
Jianxing He
ResearchOpen Access06 Sept 2017
Scientific Reports

Volume: 7, P: 1-10
An open dataset for intelligent recognition and classification of abnormal condition in longwall mining

Wenjuan Yang
Xuhui Zhang
Dian Zhao
ResearchOpen Access27 Jun 2023
Scientific Data

Volume: 10, P: 1-15
Emerging recombination of the C2 sub-genotype of HFMD-associated CV-A4 is persistently and extensively circulating in China

Tianjiao Ji
Yue Guo
Wenbo Xu
ResearchOpen Access20 Sept 2019
Scientific Reports

Volume: 9, P: 1-10
Chromosome genome assembly and annotation of the yellowbelly pufferfish with PacBio and Hi-C sequencing data

Yitao Zhou
Shijun Xiao
Zhen Huang
ResearchOpen Access08 Nov 2019
Scientific Data

Volume: 6, P: 1-8
Excitonic complexes and optical gain in two-dimensional molybdenum ditelluride well below the Mott transition

Zhen Wang
Hao Sun
Cun-Zheng Ning
ResearchOpen Access10 Mar 2020
Light: Science & Applications

Volume: 9, P: 1-10
Asynchronous pulse responses of soil carbon and nitrogen mineralization to rewetting events at a short-term: Regulation by microbes

Xiaoli Song
Jianxing Zhu
Changhui Wang
ResearchOpen Access08 Aug 2017
Scientific Reports

Volume: 7, P: 1-10
Endpoint surrogacy in oncology Phase 3 randomised controlled trials

Jianrong Zhang
Meagan R. Pilar
Jianxing He
Editorial26 May 2020
British Journal of Cancer

Volume: 123, P: 333-334

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