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The immunomodulatory functions of mast cells (MCs) within the tumor microenvironment are elusive. Here, the authors present a transcriptomic characterization of LUAD-infiltrating MCs and identify a proinflammatory subset that contributes to the activation of cytotoxic MAIT cells by secreting IL-18 via NRLP3 activation and pyroptosis, ultimately boosting anti-tumor immunity.

Topological materials hold great promise for dissipationless information transmission. Here, the authors create Chern insulator junctions between domains with different Chern numbers in MnBi₂Te₄ to realize the basic operation of a topological circuit.

In a large-scale, international, multicenter, phase 1/1b trial, treatment of patients with advanced solid tumors with the B7H3-targeting antibody–drug conjugate YL201 was safe and showed preliminary clinical efficacy.

Graphdiyne membranes with an extended two-dimensional network structure and ordered one-dimensional channels achieve an ultra-high water/NaCl selectivity and superior salt rejection.

DNA methylation data of whole blood from Han Chinese individuals are used to map mQTLs, finding that cis- and trans-mQTLs show distinct patterns of East Asians (EA) ancestry-specific colocalization with complex trait variation.

The male-sterilems2 mutant has facilitated commercial production of wheat for over 40 years. Here, Xia et al. map Ms2and describe how a retrotransposon insertion event in the regulatory element of an orphan gene is associated with expression in anthers and development of male sterility.

Tiller number is an important agronomic trait of wheat. Here, the authors clone a positive regulator of wheat tiller number and show that the encoded ankyrin repeat protein can promote tiller bud outgrowth through inhibiting ABA biosynthesis and signaling.

The molecular classification and tumour microenvironment in intrahepatic cholangiocarcinoma (iCCA) need further characterisation. Here, the authors perform single cell RNA-sequencing from 14 pairs of iCCA tumours and non-tumour liver tissues and propose S100P and SPP1 as markers for patient classification.

Bulk high-temperature superconductivity observed in pressurized tetragonal La₂PrNi₂O₇ was testified by detecting clear diamagnetic signals below about 75 K with appreciable superconducting shielding volume fractions at a pressure of above 15 GPa.

This study presents an iodine sensor fabricated using AgI-functionalized graphene, which exhibits fast response and recovery times with an ultralow detection limit, surpassing safety standards and outperforming commercial counterparts

The heterogeneity of CARM1 for the first cell fate bias in mice arises from exon-skipping splicing of Carm1 pre-mRNAs, which is regulated by the competition between LincGET-paraspeckles and splicing speckles for binding to the Carm1 locus.

The study reveals defective maternal mRNA deadenylation in oocytes matured in culture dishes versus natural ones, potentially explaining lower fertility in assisted reproduction with immature oocytes.

The shuttle effect of polysulfides in lithium sulfur batteries leads to performance degradation. Here, authors use fiber-based sensors to track and quantify the dissolved polysulfide concentration in the electrolyte during cell charge and discharge, revealing insights on stability and performance.

Electrochemical carbon monoxide reduction is a promising strategy to yield valuable multicarbon products but low selectivities and Faradaic efficiencies are common. Here the authors show single atom copper catalyst supported on MXene with high CO reduction performance and stability.

The role of aggresomes in tumorigenesis and cancer progression remains to be explored. Here, the authors perform multi-omics and reveal that aggresome formation supports ovarian cancer stem cell properties via OTUD1 and ASK1/JNK signalling activation.

Comprehensive poly(A)-inclusive RNA isoform sequencing throughout the human oocyte and preimplantation embryo development reveals poly(A)-tail-mediated maternal mRNA remodeling that is essential for human embryo development.

The South African quality protein maize (QPM) cultivars have the desired high lysine content and kernel hardness due to o2 mutation and the introgression of modifiers of o2 (Mo2) QTLs, respectively. Here, the authors assemble the genome of a QPM line and identify candidate genes underlying Mo2 QTLs.

Carbon nanomaterials such as graphene show intriguing molecular transport properties, but to achieve regular channels over a large area requires perfect sheet alignment. Here, a large-area two-dimensional conjugated-polymer-framework is grown with regular pore distribution, enabling 99.5% salt rejection by forward osmosis.

Here, the authors report intrinsic donor bound dark exciton states with associated phonon replicas in monolayer WSe₂, and defect control crystal synthesis for the deterministic creation of these states.

Non-obstructive azoospermia affects 1% of men. Here, authors perform single-cell transcriptomic analysis of human testicular cells from healthy donors and non-obstructive azoospermia patients and find that inhibition of Wnt signaling promotes the maturation of Sertoli cells from patients.

Monolayer and few-layer materials present interesting spin and pseudospin states. A study of the coupling between spin, valley and layer degrees of freedom in bilayer WSe₂ reveals coherent superpositions of distinct valley configurations and suggests the possibility of electrical control of the spin states.

Exotic states emerge from the interplay between band topology and ferromagnetism, but it remains less known in canted-antiferromagnetic phase. Here, the authors realize a canted-antiferromagnetic Chern insulator in atomically-thin MnBi₂Te₄ with electrical control of chiral-edge state transport.

A cynomolgus monkey model deficient in SIRT6 protein exhibits severe retardation in prenatal development, in which neuronal differentiation is delayed by activation of the H19 long non-coding RNA.

The electronic structure of strongly correlated materials is highly sensitive to external perturbations such as photoexcitation, leading to exotic properties and phases. Here, the authors observe extremely slow hot carrier cooling and a photo-induced insulator-to-metal transition in a Mott insulator α-RuCl3 with scanning ultrafast electron microscopy.

Today’s energy systems rely on rechargeable batteries but the growing demand raises environmental concerns. As more data become available, sensing can play a key role in advancing utilization strategies for new and used lithium-ion devices. This Review discusses how optical sensors can help to improve the sustainability of batteries.