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Commonly used opioids for pain management primarily target the mu opioid receptor. However, mu opioid receptor agonists often come with harmful side effects. Here, the authors report the results of two phase 3 trials of HSK21542 (anrikefon), a highly selective activator of peripheral kappa opioid receptor agonists, for postoperative pain treatment following abdominal surgery.

Understanding the structural relationship and electronic states between incommensurate/commensurate phases remains an ongoing challenge. Here, the authors report incommensurate structures and electronic roughness on the surface of cleaved IrTe₂.

Monolayer transition metal dichalcogenide heterostructures with type II band alignment have generated wide interest in device physics at the two-dimensional limit. Here, Rivera et al. observe interlayer excitons in vertically stacked MoSe2–WSe2 heterostructures and demonstrate tunability of the energy and luminescence.

Single layers of group-VI transition metal dichalcogenides have emerged as direct bandgap semiconductors in the two-dimensional limit. The authors show that monolayer molybdenum diselenide is an ideal system enabling electrostatic tunability of charging effects in neutral and charged electron-hole pairs, so-called excitons.

Van der Waals heterostructures offer a platform for harnessing the spin-valley degree of freedom for information processing. Here, the authors transfer optically generated spin-valley polarization from one layer to another in a two-dimensional molybdenum diselenide–tungsten diselenide heterostructure.

Topological materials hold great promise for dissipationless information transmission. Here, the authors create Chern insulator junctions between domains with different Chern numbers in MnBi₂Te₄ to realize the basic operation of a topological circuit.

Nonlinear optical phonons often exhibit rapid decay. Here, the authors demonstrate long-lived nonlinear optical phonons through the spontaneous formation of phonon frequency combs in CrXTe₃ (X=Ge,Si).

Yang, Yan, Ma et al. provide a comprehensive lactylome analysis of hepatocellular carcinoma patients, and show that analysis of protein lactylation can help uncover mechanisms that couple metabolic flux with metabolic alterations in hepatocellular carcinoma.

In a large-scale, international, multicenter, phase 1/1b trial, treatment of patients with advanced solid tumors with the B7H3-targeting antibody–drug conjugate YL201 was safe and showed preliminary clinical efficacy.

Unconventional unidirectional magnetoresistance observed in the heterostructures of a topological semimetal (WTe₂) and a magnetic insulator (Cr₂Ge₂Te₆) enables the electrical read-out of the magnetic states of a perpendicularly polarized magnet through longitudinal resistance measurements.

Bulk high-temperature superconductivity observed in pressurized tetragonal La₂PrNi₂O₇ was testified by detecting clear diamagnetic signals below about 75 K with appreciable superconducting shielding volume fractions at a pressure of above 15 GPa.

This study presents an iodine sensor fabricated using AgI-functionalized graphene, which exhibits fast response and recovery times with an ultralow detection limit, surpassing safety standards and outperforming commercial counterparts

Periodic laser light can modify the electronic properties of solids and offers a path to create new material phases. In a topological antiferromagnet, periodic driving with opposite light helicities is now shown to produce distinct Dirac mass gaps.

The cytokine like protein FAM3D (Fam3D in mice) is highly expressed in the digestive tract with unknown role in colon pathophysiology. Here, by using gene deficient mice, the authors show that Fam3D is critically involved in colon homeostasis, host defense against colitis-associated carcinogenesis, and the balance of microbiota.

Ovarian aging has an important role in health and fertility; however, the molecular mechanisms underlying it remain incompletely understood. Here the authors use single-cell and spatial transcriptomics in reproductively young, middle-aged and older human ovarian tissue to elucidate ovarian aging. They describe spatiotemporal changes in ovarian cells and highlight the important regulatory role of FOXP1.

One way of producing Majorana fermions for topological quantum computing is to induce superconductivity in other topological states. Here, the proximity effect does this for the quantum spin Hall effect state in a 2D material.

Fe-based superconductors have attracted tremendous interest recently. New evidence on BaFe₂As₂ shows that chemical doping and pressure, both of which induce superconductivity, distort the lattice in similar ways. The result provides important information in the quest for an understanding of the mechanism behind superconductivity.

Bright and electrostatically tunable electroluminescence from monolayer WSe₂ p–n junctions is reported.

An upconversion from negatively charged to neutral excitons is observed in monolayer tungsten diselenide, which could provide a route for cooling two-dimensional semiconductors using lasers.

Metallic nanowires can be sculpted out of semiconducting transition-metal dichalcogenide monolayers using focused electron-beam irradiation and have self-adaptive contacts to the semiconducting monolayers they are made from.

Monolayer and few-layer materials present interesting spin and pseudospin states. A study of the coupling between spin, valley and layer degrees of freedom in bilayer WSe₂ reveals coherent superpositions of distinct valley configurations and suggests the possibility of electrical control of the spin states.

Magnetic order in a manganite can be switched during femtosecond photo-excitation via coherent superpositions of quantum states; this is analogous to processes in femtosecond chemistry where photoproducts of chemical and biochemical reactions can be influenced by creating suitable superpositions of molecular states.

Excitonic valley quantum coherence is optically generated and detected by polarization-resolved photoluminescence spectroscopy in the monolayer semiconductor WSe₂.

Second-order optical nonlinearities can be controlled, up to room temperature, by electrostatic gating in a field-effect transistor made from atomically thin crystals of WSe₂.

A miniature laser is reported that uses two-dimensional tungsten diselenide as the active medium, which is placed on a photonic crystal membrane that acts as the laser cavity; the laser emits visible light, with an ultralow pump threshold.

MoTe₂ is reported to host type II topological Weyl semimetal states. Two sets of Weyl points exist at different energies above the Fermi energy. Fermi arcs that form closed loops and are unique to type II Weyl semimetals are also found.

Anti-melanoma differentiation-associated gene 5-positive dermatomyositis is a severe autoimmune disease with largely unknown aetiology. Here authors identify the key immune cell types that contribute to the disease phenotype and implicate type I interferons signalling in the patho-mechanism.

The authors report on the emergence of intercell moiré exciton complexes where, in H-stacked WS₂/WSe₂ heterobilayers, the exciton’s hole from the WSe₂ layer is surrounded by its bound electron’s wavefunction distributed among three adjacent moiré traps in the WS₂ layer exhibiting an out-of-plane dipole and in-plane quadrupole.

In multilayer WSe₂, dipolar excitons with Coulomb-bound electron and hole pairs located in every other layer show unique valleytronic superlattice structure and electrical tunability.

The authors demonstrate the tunability of moiré potential and emergent moiré exciton Rydberg states in a monolayer transition metal dichalcogenide governed by an adjacent twisted bilayer graphene near the magic angle with gate-tunable local charge density.

The role of aggresomes in tumorigenesis and cancer progression remains to be explored. Here, the authors perform multi-omics and reveal that aggresome formation supports ovarian cancer stem cell properties via OTUD1 and ASK1/JNK signalling activation.

Strong dipole–dipole interactions between excitons in a moiré superlattice create a manifestation of the Bose–Hubbard model with a ground state similar to a Mott insulator.

In monolayer semiconductors phonons with momentum vectors pointing to the corners of the hexagonal Brillouin zone couple strongly to carriers’ spin and valley degree of freedom. Here, the authors report the observation of multiple valley phonons and the resulting exciton complexes in the monolayer semiconductor WSe₂.

Quasi-one-dimensional substructures have distinctive properties, but the lattice dynamics are poorly understood. Here, Chen et al.use inelastic neutron scattering and density functional theory to discover that numerous low-energy optical vibrational modes including a twisting polarization are present in higher manganese silicides.

Hydrogen can be incorporated within a solid and drastically modify its electronic and structural state. Here, the authors report reversible binding of H⁺ ions to chalcogens in the Bi₂Te₃ class of topological insulators and magnets, allowing Fermi level tuning into the bulk gap without altering carrier mobility or the bandstructure.

MnBi2Te4, referred to as MBT, is a van der Waals material combining topological electron bands with magnetic order. Here, Lujan et al study collective spin excitations in MBT, and show that magnetic fluctuations increase as samples reduce in thickness, implying less robust magnetic order.

The authors show that an out-of-plane antidamping spin–orbit torque can produce a sizeable change in the switching dynamics of a magnetic layer with perpendicular anisotropy.

Exotic states emerge from the interplay between band topology and ferromagnetism, but it remains less known in canted-antiferromagnetic phase. Here, the authors realize a canted-antiferromagnetic Chern insulator in atomically-thin MnBi₂Te₄ with electrical control of chiral-edge state transport.

A study reveals light as a new dynamic knob to control ferromagnetic order in moiré superlattices.

Here, the authors report intrinsic donor bound dark exciton states with associated phonon replicas in monolayer WSe₂, and defect control crystal synthesis for the deterministic creation of these states.

Free carriers and electrical polarization coexist in ferroelectric metals. Here, the authors use a capacitive method to probe the electronic compressibility of free carriers in a tunable semimetal, extract the polarized contribution, and study the carrier dependence of the ferroelectric state.

Tracking a battery’s chemical and thermal states during operation offers important information on its reliability and lifetime. Here the authors develop optical fibre sensors and decouple temperature and pressure variations in the measurements inside of batteries, allowing chemical and thermal events to be monitored with high accuracy.

The electronic structure of strongly correlated materials is highly sensitive to external perturbations such as photoexcitation, leading to exotic properties and phases. Here, the authors observe extremely slow hot carrier cooling and a photo-induced insulator-to-metal transition in a Mott insulator α-RuCl3 with scanning ultrafast electron microscopy.

Moiré trions are observed in electrostatically gated WSe₂/MoSe₂ heterobilayers, where photoluminescence polarization switching reveals a competition between valley-flip and spin-flip relaxation pathways of photo-excited carriers during trion formation.

Transport measurements on the Kitaev quantum spin liquid candidate α-RuCl3 subjected to a magnetic field reveal oscillating behaviour in its thermal conductivity, reminiscent of Shubnikov de Haas oscillations in metals.