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Genetic basis of the drought tolerance of upland rice is unclear. Here, the authors report the cloning of a COBRA-like protein encoding gene DROT1 and reveal that it is repressed by ERF3 and activated by ERF71 to help control the balance between growth and drought tolerance in upland rice.

Autonomous delivery of exogenous cargo into plant tissues is achieved by a nanocarrier system harnessing amino acid transporters, enabling force-free, species-independent uptake and ultra-low dose drought resistance in crops like soybean and maize.

A hybrid cathode interfacial layer (AZnO-F3N) is developed, delivering 21.0% efficiency along with excellent stability, mechanical robustness and broad versatility, highlighting its potential to advance organic solar cells.

Ultrafast electron diffraction can probe structural dynamics of photochemical reactions in real space and real time. Here the authors study the ring-opening of cyclohexadiene with sub-100 fs temporal resolution and sub-angstrom spatial resolution.

Viruses exploit host cell machinery for replication, but their spatial cues remain elusive. Using nanochip-enabled membrane shaping, the authors discover saddle curvature association of viral proteins, revealing a new spatial regulation mechanism.

Enzyme-bound ketyl radicals derived from thiamine diphosphate are selectively generated through single-electron oxidation by a photoexcited organic dye and shown to lead to enantioselective radical acylation reactions.

Dendritic cell-based therapies have been exploited as immunotherapeutic approaches for cancer treatment. Here the authors report a platform integrating antigen-capturing nanoparticles and type 1 conventional dendritic cells for in situ cancer immunization, promoting anti-tumor immunity in preclinical models.

Granular materials transition between unjammed and jammed states when adjusting their packing density. Here, authors find that the same kind of phase transition can be alternatively achieved through temperature-controlled particle shape change.

Current noble metal catalysts enable efficient proton exchange membrane water electrolysis but suffer from instability. Here, the authors report an agglomeration and smelting strategy to create ruthenium-based nanoarray catalysts, enabling water electrolysis for over 500 hours at 1 A cm⁻².

There are now several van der Waals magnets that have been shown to host skyrmions, however, these are typically hampered by a low Curie temperature, restricting the temperature at which the skyrmions can exist. Here, Zhang, Jiang, Jiang and coauthors find a skyrmion lattice in the van der Waals magnet Fe3 − xGaTe2 above room temperature and demonstrate the critical role of symmetry breaking in crystal lattice in the origin of these skyrmions.

Reducing platinum use is vital for sustainable hydrogen production via proton exchange membrane water electrolysis. Here, the authors report a Mo₂TiC₂ MXene-supported platinum nanocluster catalyst that requires minimal platinum content and operates efficiently for over 8700 h.

F-type phage-tail like bacteriocins (PTLBs) are protein complexes with bactericidal activity and share similarity with non-contractile phage tails. Here, authors report the atomic structure of monocin, an F-type PTLB from listeria monocytogenes.

While Bell inequalities have been violated several times—mostly in photonic systems—their violations within particle physics experiments are less explored. Here, the BESIII Collaboration showcases Bell-violating nonlocal correlations between entangled hyperon pairs.

A large electronic display textile that is flexible, breathable and withstands repeated machine-washing is integrated with a keyboard and power supply to create a wearable, durable communication tool.

TGFbeta is known to promote cancer metastasis through the promotion of epithelial-mesenchymal transition (EMT). Here, the authors demonstrate that a TGFbeta induced circular RNA (circITGB6) promotes colorectal cancer metastasis via activation of the m6A reader protein, IGF2BP3, resulting in stabilization of an EMT-promoting gene, PDPN.

Studies on the µ-opioid receptor using fluorescent labelling of intracellular residues and energy transfer experiments in the presence of different ligands with or without G-protein binding reveals conformational changes that correlate to ligand efficacy.

A new strategy to reduce charge leakage in quantum-dot light-emitting diodes enables high external quantum efficiencies of 28.7% and 21.9% and excellent T₉₅ lifetimes of 580,000 h and 4,400 h for green and blue devices, respectively.

Two divergent haplotypes from a highly heterozygous lychee genome of the cultivar ‘Feizixiao’ and resequencing of 72 lychee accessions provide insights into the genome evolution and domestication history of lychee.

A three-channel spinneret simultaneously extrudes and combines electrodes and electrolyte to make 1,500-km-long fibre batteries.

Here, the authors report a polymer-free transfer method to fabricate suspended 2D materials with high intactness and thermal conductivity, facilitating the application of graphene grids for high-resolution electron microscopy.

Exploiting negative capacitance effects in organic thin-film transistors (OTFTs) is advantageous for enhancing device performance. Here, the authors report solution-processed sub-thermionic OTFTs and circuits with ferroelectric hafnium oxides that show ultra-low power and ultra-high gain.

In this study the authors report USP48 and BRAF are frequently mutated in USP8 wild-type corticotroph adenomas, and cause Cushing’s disease mainly through promoting the promoter activity of POMC. Inhibition of BRAF may be a promising therapeutic strategy for the treatment of patients with BRAF-mutated corticotroph adenomas.

Individuals with SYK gain-of-function variants develop immunodeficiency and systemic inflammation, which are recapitulated in a knock-in mouse model. Treatment of these mice with bone marrow transplantation or with a SYK inhibitor ameliorates disease symptoms, highlighting potential therapeutic strategies for patients with SYK mutations.

Single-atom catalysts maximize metal atom efficiency and exhibit properties that can be considerably different to their nanoparticle equivalent. Now a general host–guest strategy to make various single-atom catalysts on nitrogen-doped carbon has been developed; the iridium variant electrocatalyses the formic acid oxidation reaction with high mass activity and displays high tolerance to CO poisoning.

In this Review, the authors present a roadmap towards achieving consensus on development, analysis and interpretation of single-cell transcriptomics data in adipose tissue, including discussion of roadblocks, best practices and ideal cell-type markers for annotation of adipose tissue cell types in mice and humans.

The energy-coupling factor transporters are responsible for vitamin uptake in prokaryotes. Here, the X-ray crystal structure of the membrane-embedded, substrate-binding domain of a riboflavin transporter from Staphylococcus aureus is reported. The transporter adopts a previously unreported fold and contains a riboflavin molecule bound to a loop and the periplasmic portion of several transmembrane segments.

Here, authors successfully fabricated a springtail-inspired nano-concave reentrant structured polystyrene (PS) membrane using electrospraying technology followed by lubricant dip-coating, which endowed the membrane with omniphobic properties.

Using the burden of proof analytical tool, a meta-analysis found weak or no evidence of associations between unprocessed red meat consumption and increased risk of six cardiometabolic disease and cancer outcomes.

A meta-analysis using the Burden of Proof function identified modest evidence supporting a protective role of vegetable consumption against ischemic heart disease, stroke and esophageal cancer but not type 2 diabetes.

The building envelope is the interface between a building and its surrounding environment, and has a substantial impact on energy efficiency and aesthetic appeal. Here the authors present a coloured low-emissivity film design that could work year-round to save energy.

To efficiently unlock the cooling power of sweat for human body remains a great challenge for next-generation textiles. Here the authors report an integrated cooling (i-Cool) textile showing high evaporation ability and sweat evaporation cooling efficiency for personal perspiration management.

The authors deposit non-superconducting metallic thin films on surfaces of the kagome Chern magnet TbMn₆Sn₆ and observe emergent superconductivity even though neither component is a superconductor. Furthermore, the superconducting state is quasi-two-dimensional and coexists with ferromagnetism, consistent with possible spin-triplet pairing and topological superconductivity.

A large spin Hall angle and long spin diffusion length are found in the low-symmetry, few-layer semimetal MoTe₂ at room temperature, thus identifying this material as an excellent candidate for simultaneous spin generation, transport and detection.

The application of 2D MoS₂ flexible integrated circuits (ICs) is currently limited by the material quality over large areas and the device fabrication technology. Here the authors report a gate-first fabrication technique to realize wafer-scale monolayer MoS₂ ICs on rigid and flexible substrates with high performance and low power consumption.

Cu-based catalysts for the conversion of C₂H₂ to C₂H₄ are plagued by side reactions. Here, Cu nanodots for C₂H₂ semihydrogenation are reported to reach current densities >400 mA cm⁻² and selectively produce polymer-grade ethylene over 130 h.

Intrinsically disordered regions of GPCRs have been understudied for their role in receptor signaling. Here, Jie Heng et al. reveal the dynamic behavior of β2 adrenergic receptor C-terminus and its autoinhibitory function in downstream Gs coupling.

Nanonization of battery electrode particles is a usual way to enhance their conductivity, but the decreased tap density is detrimental to battery performance. Here, the authors coat micron-sized lithium iron phosphate with a conducting polymer layer and demonstrate some excellent electrochemical properties.

Targeting cancer-associated metabolism is evolving as a promising approach for cancer therapy. Here, the authors generate cancer cell-membrane encapsulated nanoparticles to induce cell cycle arrest and cytotoxicity in lactate-high cancer cells, reducing tumourigensis in glioblastoma cell-line and patient-derived models.

A new Burden of Proof meta-analytic method that accounts for between-study heterogeneity and corrects for bias between different study designs is used to interpret the strength of evidence between different pairs of risk factors and health outcomes.

A meta-analysis using the Burden of proof method reported consistent evidence supporting harmful associations between smoking and 28 different health outcomes.

Reliable transfer techniques are critical for the integration of 2D materials with arbitrary substrates. Here, the authors describe a method to transfer 4-inch and A4-sized defect-free graphene films onto rigid and flexible substrates with controllable conformal contact, leading to improved electrical properties and uniformity.

A systematic review using the burden of proof meta-analytic method found a significant harmful effect between high systolic blood pressure and ischemic heart disease.