The impact of chemical chirality on immune response attracts attention in cancer vaccine design recently. Here this group reports the chirality of poly(γ-ethyl-D-glutamate)-based hydrogel exhibiting higher levels of suppression on antigen-presenting cells and inducing stronger T cell exhaustion than L-Gel eventually leading to insufficient anti-tumor efficacy.
- Junfeng Ding
- Tianran Wang
- Chaoliang He
