Strategies to synthesize a chemiluminescence (CL) emission unimolecular skeleton in the second near-infrared window (NIR-II) and a unimolecular probe with direct duplex NIR-II [CL/fluorescence (FL)] emission are lacking. Here, the authors employ modular synthesis routes to construct a series of directly activated NIR-II CL emission unimolecular probes with a maximum emission wavelength of up to 1060 nm, and use them for real-time and continuous detection of the superoxide anion generated in acetaminophen induced liver injury under both NIR-II CL and NIRII FL imaging channels.
- Zhongxiang Chen
- Qian Li
- Jibin Song
