S-chirogenic pharmacophores play an essential role in drug discovery within bioscience and medicinal chemistry. Here, the authors report a methodology for synthesizing diverse classes of S-chirogenic sulfinamides through asymmetric reductive addition of aryl and alkenyl halides to sulfinylamines via common-Earth-metal catalysis.
- Xiaowu Fang
- Longlong Xi
- Zhuangzhi Shi
