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Showing 1–10 of 10 results
Advanced filters: Author: Jillian Phallen Clear advanced filters

  • DNA from tumour cells can be detected in the blood of cancer patients. Here, the authors show that cell free DNA fragmentation patterns can identify lung cancer patients and when this information is further interrogated it can be used to predict lung cancer histological subtype.

    • Dimitrios Mathios
    • Jakob Sidenius Johansen
    • Victor E. Velculescu
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-14

  • Cell free DNA fragmentation is a promising biomarker for disease, but its epigenetic regulation is incompletely understood. Here, the authors investigated the effects of DNA methylation in the production of cfDNA fragmentation, and corelate these changes with gene expression in human cancer.

    • Michaël Noë
    • Dimitrios Mathios
    • Victor E. Velculescu
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-11

  • Analyses of fragmentation patterns of cell-free DNA in the blood of patients with cancer and healthy individuals using a machine learning algorithm provide a proof-of principle approach for the early detection and screening of human cancer.

    • Stephen Cristiano
    • Alessandro Leal
    • Victor E. Velculescu
    Research
    Nature
    Volume: 570, P: 385-389

  • Somatic mutations are identified from circulating cell-free DNA using a single-molecule-based lowpass whole-genome sequencing method. The regional distribution of mutations can identify a tumor-specific mutational profile in patients with cancer and can be used to monitor patients through treatment.

    • Daniel C. Bruhm
    • Dimitrios Mathios
    • Victor E. Velculescu
    ResearchOpen Access
    Nature Genetics
    Volume: 55, P: 1301-1310

  • Identifying patients that will respond to a particular therapy remains a key challenge in precision oncology. Here, in gastric cancer, the authors show that circulating tumour DNA can predict recurrence, provided that the signal from white blood cells is filtered out.

    • Alessandro Leal
    • Nicole C. T. van Grieken
    • Victor E. Velculescu
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-11

  • Somatic mutations have been reported in pancreatic adenocarcinomas. Here, Sausen et al. identify further mutations and find that mutations in the chromatin modifying gene, MLL, are associated with increased survival, and that the presence of circulating tumour DNA in the serum of patients is associated with poor survival.

    • Mark Sausen
    • Jillian Phallen
    • Victor E. Velculescu
    Research
    Nature Communications
    Volume: 6, P: 1-6

  • It has previously been proposed that high-grade serous ovarian carcinoma (HGSOC) may originate from the fallopian tube. Here, the authors analyze genetic aberrances in fallopian tube lesions, ovarian cancers, and metastases from HGSOC patients and establish the evolutionary origins of HGSOC in the fallopian tube.

    • S. Intidhar Labidi-Galy
    • Eniko Papp
    • Victor E. Velculescu
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-11

  • In this Review, Bruhm et al. provide a comprehensive overview of targeted and genome-wide cell-free DNA detection approaches, examining their potential to complement existing screening programmes or enhance early cancer detection for those cancers without effective screening methods.

    • Daniel C. Bruhm
    • Nicholas A. Vulpescu
    • Victor E. Velculescu
    Reviews
    Nature Reviews Cancer
    Volume: 25, P: 341-358