Search

The electrical control of heat flow at the nanoscale remains challenging. Here, the authors demonstrate up to 80% gate modulation of the entropy-carrying heat waves (named demon modes) in graphene via on-chip time-resolved terahertz microscopy.

This study identifies GCN5, a histone acetyltransferase, as a driver of metabolic dysfunction-associated steatotic liver disease progression via LXRα/SREBP1c-mediated lipogenesis, and demonstrates that pharmacological inhibition of GCN5 alleviates disease in a study with male mice.

This study introduces a two-stage electrochemical method for lithium recovery from spent LiNi_1/3Co_1/3Mn_1/3O₂ (NCM) batteries, achieving over 98% efficiency with nearly 50% less electric energy use via lattice oxygen oxidation and ion exchange.

Droplet microlasers are emerging as powerful tools for label-free biosensing. Here, the authors demonstrate a new method for creating liquid photonic-molecule microlasers that combine low lasing threshold and enhanced sensitivity, achieving biomolecular detection limit down to attoMolar level.

Replicating the functional architecture of biological ion channels in synthetic membranes remains challenging. Here the authors design an ultramicroporous hydrogen-bonded organic framework membrane that structurally emulates the CLC chloride filter.

The performance of 2D photodetectors in the near-infrared range is usually constrained by fundamental limits. Here, the authors report hybrid photodetectors based on 2D MoS₂/WSe₂ heterostructures integrated with plasmonic metasurfaces, exploiting anapole states to enhance the responsivity and improve their chiral discrimination ratio in the telecommunication range.

Fang et al. report a scalable solution-soaking quenching technique to enable uniform passivation of large-area wide-bandgap perovskite films, resulting in 10.13 cm² solar modules with 20.32% efficiency, prolonged lifespan, and applications in tandem solar windows, transparent agrivoltaics, and portable power systems.

Phase-change materials are promising for thermal management, although achieving simultaneous phase-change stability and mechanical robustness remains challenging. Here, we present a nanotechnology-directed strategy that integrates ultralow carbon nanotubes (0.1 wt.%) scaffolds with three-dimensional interpenetrating polymer networks, achieving significant synergy between crystallinity control and efficient thermal regulation.

Emulating Schrodinger-equation-governed temporal dynamics in metamaterials is of strong interest. Here, the authors demonstrate that temporal scattering processes exhibit eigenstate topological braiding and dynamical topological phase transitions in circuit metamaterials.

Scalable fabrication of perovskite films for large-area solar cells remains a critical challenge. Jin et al. identify the solvent-precursor interaction time as a crucial, yet overlooked, kinetic parameter controlling crystallization and propose a protocol for manufacturing high-quality perovskite films.

Integrated quantum memories based on ¹⁵¹Eu³⁺:Y₂SiO₅ crystals coupled with impedance-matched optical cavities are demonstrated. Multiplexed quantum storage efficiencies of 80.3% and 69.8% are achieved for weak coherent pulses and telecom-heralded single photons, respectively.

Controllable and scalable phase transition of transition metal chalcogenides is challenging. Using in situ microscopic analysis, a non-stoichiometric phase transition from PdTe₂ to PdTe is observed on the atomic scale, providing mechanistic insights into the scalable phase engineering of transition metal chalcogenide films and heterostructures.

Humanity’s Last Exam, a multi-modal benchmark at the frontier of human knowledge, is designed to be an expert-level closed-ended academic benchmark with broad subject coverage.

Wearable silent speech systems hold potential for restoring communication in patients suffering from speech impairments. Tang et al. report an AI-driven silent speech system for dysarthria patients, which enables zero-time-delay expression and context-aware emotion decoding-based sentence expansion.

T-cell engager (TCE)-based immunotherapy requires further development in solid tumors due to limited T cell penetration, immunosuppressive tumor microenvironment and toxicity. The authors here develop a glypican-3 targeting mRNA TCE (MTS105) which manifests superior T cell activation and tumor regression hepatocellular carcinoma mice model comparing to conventional TCE, and safety with cynomolgus monkey studies.

Schisantherin A (Sin A), a bioactive lignan from Schisandra chinensis, alleviates obesity and liver fat accumulation in mice, but the mechanisms are incompletely understood. Here the authors show that Sin A mitigates obesity and related metabolic disorders by elevating circulating conjugated bile acids, which in turn modulate adipose tissue thermogenesis in mice.

Biomimetic membranes can be used for various applications such as sensors and separations. Here, Chen et al. report the assembly of lipid-like peptoids into stable and self-repairing 2D membrane nanomaterials that change in thickness when under external stimuli.

This study presents LoopID, which profiles proteins at targeted interacting enhancer–promoter (E-P) pairs, identifying the histone demethylase JMJD2 as a regulator of E-P interactions through biomolecular condensate formation independent of its catalytic activity.

Nature Biotechnology asks selected members of the international community to comment on the ethical issues raised by the prospect of CRISPR-Cas9 engineering of the human germline.

The STAR experiment at the Relativistic Heavy Ion Collider at Brookhaven National Laboratory demonstrates evidence of spin correlations in \(\Lambda \bar{\Lambda }\) hyperon pairs inherited from virtual spin-correlated strange quark–antiquark pairs during QCD confinement.

RNF214 ubiquitin ligase is understudied. Here the authors show RNF214 promotes hepatocellular carcinoma progression by inducing non-proteolytic ubiquitylation of TEADs and activating YAP signaling pathway.

Estimates from the Global Burden of Disease study reveal declines in chronic respiratory disease mortality between 1990 and 2023—especially during the COVID-19 pandemic—but the burdens on people affected remain substantial.

Lactate fuels cancer growth by activating ERK signaling through GCN5-mediated lactylation of ERK, which disrupts ERK–MEK interactions. Development of a cell-penetrating peptide blocking lactylation slows KRAS-mutant tumor development.

Organic molecular crystals with controllable bending angles are crucial interconnectors in integrated optoelectronic chips but current methods of tailoring bent geometric features in molecular crystals without fracturing remain limited. Here the authors proposing a molecular cocrystal strategy that introduces directional non-covalent interactions into molecular systems to weaken the original interactions triggering the spontaneous deformation.

Li Dong Wang and colleagues report a genome wide association study for esophageal squamous cell carcinoma in the Chinese population. They identify two risk loci at PLCE1 and C20orf54.

Quantum low-density parity-check error correction codes are anticipated to deliver high performance, but require long-range qubit–qubit interactions. Two of these error correction codes have now been successfully implemented on a superconducting device.

Schizophrenia risk at 1p36.23 lacked functional insight. Here, the authors identify two enhancer variants that upregulate RERE, which disrupts neurogenesis and synaptic function by regulating Grin2a, linking genetic risk to neuronal development and excitatory signaling.

The presence of EGFR mutations and de novo MET aberrations limited response to EGFR inhibitors in patients with advance non-small cell lung cancer (NSCLC). Here, the authors report a phase 2 randomised clinical trial investigating first-line osimertinib (EGFR inhibitor) plus savolitinib (c-MET inhibitor) in patients with MET-aberrant, EGFR-mutant advanced NSCLC.