Search

RNA polymerase II (RNAPII) is typically considered as an essential enzyme. Here the authors show that natural degradation of RNAPII drives chromatin reorganization in growing oocytes, preparing the chromatin for genome activation after fertilization.

In nasopharyngeal carcinoma (NPC), cisplatin is known to be associated with poor treatment compliance and notable side effects therefore more effective platinum drugs are expected. Here this group updates the 10-year survival analysis results of a multicenter, randomized, phase 3 trial evaluating the efficacy of lobaplatin and fluorouracil induction chemotherapy plus concurrent chemoradiotherapy on 502 NPC patients.

Alternative splicing greatly expands the transcriptomic and proteomic diversity in vertebrates. Here, the authors develop a machine-learning tool to identify functional splicing events during hematopoietic cell differentiation, revealing new regulators of hematopoiesis.

The authors report the synthesis and characterization of samarium-based superconducting infinite layer nickelate thin films, along with co-doped variants incorporating europium and calcium. The co doped compounds achieve a record-small c-axis parameter and display superconducting transition temperatures up to 32.5 K.

Spin-crossover complexes are promising candidates for molecular bits owing to their magnetic bistability but engineering high-density bits is challenging due to cooperative switching dynamics. Here the authors modulate the cooperative dynamics of surface-confined spin-crossover complex chains.

KIAA1199 is upregulated in colorectal cancer (CRC), associated with metastasis and poor clinical outcomes. Here the authors report that extracellular vesicles secreted by KIAA1199-high CRC cells functionally reprogram hepatocytes to support the infiltration of Egr1⁺ neutrophils, resulting in accelerated liver metastatic colonization.

Lipid Nanoparticles (LNPs) effectively deliver mRNA to cells but suffer have low levels of endosomal release. Here the authors report on core-shell LNPs with ionizable lipid–coated gold nanoparticle cores with enhanced pH-responsive membrane disruption, endosomal escape, and cytosolic mRNA delivery improving therapeutic efficiency.

This study discovers an allosteric site on the enzyme FUT8 and develops a selective covalent inhibitor, CAIF. CAIF blocks core fucosylation and suppresses cancer cell invasion in vitro, revealing a promising strategy against FUT8-driven diseases.

‘Liquid crystal elastomers are of interest for soft robotics and smart textiles, though existing fabrication methods limit complex actuation. Here the authors report an extrusion method to program a dynamic covalent network for complex actuation.’

Here they show that NONO collaborates with HOXA1 to modulate gene expression during early cardiomyocyte differentiation. This interaction facilitates activation of the Wnt signaling pathway, establishing the NONO-HOXA1-Wnt axis as a key mechanism in cardiac development.

The role of RNA-binding protein (RBP) phase separation in transcriptional regulation and its contribution to tumorigenesis remains to be characterised. Here, the authors show that RBP AKAP95 physically co-condenses with the mixed lineage leukemia 1 (MLL1) translocated fragment commonly found in MLL rearranged (MLLr) leukemia to promote leukemogenesis.

Researchers study the transition from bound states in the continuum (BICs) to quasi-BIC caused by out-of-plane asymmetry and illustrate how quality factors of BIC resonances are valuable tools for precise chip patterning accuracy.

Cryogenic transport measurements of CsV₃Sb₅ nanobeams show a zero-field Josephson diode effect and radio-frequency rectification with power-dependent quantized voltage output.

The Taiwan Precision Medicine Initiative recruited and genotyped more than half a million Taiwanese participants, almost all of Han Chinese ancestry, and performed comprehensive genomic analyses and developed polygenic risk score prediction models for numerous health conditions.

Phagocytes must safely remove mitochondria released after tissue injury to prevent harmful immune activation. Here, the authors show that TMEM110 preserves lysosomal function to clear mitochondrial DNA, thereby limiting organ damage and mortality after traumatic brain injury.

Bronchiectasis and asthma can co-exist in the same patient, and the characteristics may be different from bronchiectasis alone. Here the authors characterise the function of ILC3 cells and how IL-17C potentiates IL-17A expression promoting a neutrophil dominated asthma endotype in mouse bronchiectasis-asthma models.

This study analyzes the impact of 1,436 air-quality-monitoring stations in Chinese cities. It found that these stations led to an 8.03% reduction in PM_2.5 concentrations in urban areas. Within these areas, they resulted in 0.57% more reduction in PM_2.5 concentrations in technically accessible areas compared to non-accessible areas, which also experienced an increase in housing prices and a decrease in air-quality-induced mortality.

Here the authors reveal a study of 486,956 Han Chinese individuals showing that most people with genetic variants affecting drug response do not have the predicted adverse events, highlighting the challenges of implementing pharmacogenetics in clinical practice.

The Taiwan Precision Medicine Initiative (TPMI) has built a cohort of more than half a million individuals with Han Chinese ancestry, providing a rich resource of genetic and medical data for this group.

Self-amplifying RNA enables durable therapeutic expression, but its high immunogenicity and low-fidelity replication limit its use. Here, authors engineer a Norovirus-derived VPg-saRNA platform that achieves cap-independent, low-immunogenic and precise therapeutic protein expression in vivo.

A general protocol for high-dimensional entangling gates is developed and applied for two four-dimensional qudits encoded in orbital angular momentum (OAM). The phase-locking technique stabilizes OAM sorters, leading to a process fidelity within a range from 0.71 to 0.85.

Genome-wide association analyses using data from 19 biobanks identify variants influencing risk of thyroid diseases and yield polygenic risk scores associated with features of aggressive thyroid cancer.

Estimates from the Global Burden of Disease study reveal declines in chronic respiratory disease mortality between 1990 and 2023—especially during the COVID-19 pandemic—but the burdens on people affected remain substantial.

Pulmonary type 2 inflammation is associated with type 2 innate lymphoid cells. Here the authors use the Collaborative Cross mouse panel to show that ILC2 abundance during type 2 lung inflammation is different across the panel and identify free-fatty acid receptor 3 (Ffar3) as a gene responsible and show cytokine and ILC2 functional changes.

The study used snMultiome-seq to map gene expression and chromatin accessibility in human central amygdala cells from people with and without AUD. Here, the authors show that inhibitory neurons are most affected, with KLF16-driven regulatory changes and AUD-risk variants disrupting gene activity.

This study demonstrates a low-energy photon device based on the kagome metal RbV₃Sb₅. It demonstrates that Fermi surface reconstruction, driven by a phase transition, leads to the emergence of van Hove singularities near the Fermi level.

Reducing the embodied carbon emissions of building material stock is essential for mitigation. Using a high-resolution multiyear dataset in China, researchers show the historically massive contributions of these emissions during past decades of rapid urbanization and the potential risks for future climate goals.

In this study analyzing data from 8,690,286 individuals in the Netherlands, autism significantly increased the risks for various cardiometabolic conditions. Cox proportional hazards models demonstrated heightened hazard ratios, emphasizing the importance of monitoring these health issues in people with autism.

The authors report the time-reversal symmetry breaking superconductivity in the thin-flake kagome material RbV3Sb5, manifesting primarily as an unconventional form of hysteresis that is not observed in CsV3Sb5. They also observe reentrance of superconductivity during an in-plane field-sweeping process at 400 mK.

Reactive oxygen species such as hydrogen peroxide (H₂O₂) could have arisen through abiotic processes on the early Earth and been considered a source of oxidative stress for early life. Here, the authors reveal that RNA molecules coordinated with ferrous iron can catalyze the conversion of H₂O₂ into O₂ and H₂O under anoxic conditions, suggesting RNA-metal complexes played a crucial role in managing oxidative stress before protein enzymes evolved.

Humanity’s Last Exam, a multi-modal benchmark at the frontier of human knowledge, is designed to be an expert-level closed-ended academic benchmark with broad subject coverage.

Prostate cancers (PCa) are characterized by an immunosuppressive tumor microenvironment. Here the authors identify a subset of iron-loaded cancer-associated fibroblasts secreting myeloid cell-associated proteins and driving immunosuppression in PCa.

Cerebellar ataxia, a hallmark of cerebellar degeneration (CBND), is driven by mitochondrial dysfunction in Purkinje cells. In this study, transplanting mitochondria into CBND mice improve mitochondrial function, reduce mitophagy, and reduce ataxia.

Engineered bacteria sense gut bleeding and secrete repair materials.

Mineral carbonation offers a scalable route for CO₂ removal. Here, the authors develop a water-thinning strategy to engineer confined interfacial sites that enable carbonation of calcium hydroxide under ambient conditions.

Previously undescribed hierarchical arrangements in haematopoietic stem cells and their niches that mediate both regenerative potential and immune privilege are identified.

Baryon acoustic oscillations from the early Universe are imprinted in the large-scale structure, providing a cosmic expansion ruler. A comparison of the shapes and positions of galaxies can yield an independent measure of these primordial oscillations.

A simple cut can wake up a dormant plant. New research uncovers how a wound instructs buds to resume cell division and sugar transport, driving them to sprout.

Kinematic sensors are required in many industrial applications, but the current sensor designs rely on power input from external sources. Here, Jing et al.harness the micro-meso scale ambient energy via a triboelectric generator to self-power sensors for one- and two-dimensional motion vector sensing.

Immune checkpoint inhibitor resistance limits treatment options in advanced hepatocellular carcinoma. Here, the authors report a Phase 2 trial of stereotactic body radiotherapy combined with PD-1/VEGF blockade in patients with refractory hepatocellular carcinoma.

Hanging Coffins were a mortuary tradition practiced in southern China and Southeast Asia. Here, the authors show that different groups of ancient Hanging Coffin practitioners are genetically related, and that they are ancestors of present-day Bo people.

Achieving enantioselective construction of bridged-ring scaffolds presents a challenge, due to the considerable structural strain of the products and the presence of multiple stereocenters. Herein, the authors report a Pd/Cu co-catalyzed substrate-dependent enantiodivergent tandem Heck/Sonogashira reaction for synthesis of alkyne-tethered (R,S,S)-bicyclo[3.2.1]octenes and (S,R,R)-benzo-bicyclo[3.2.1]octanes, each featuring one quaternary and two adjacent tertiary stereocenters.

In this work, authors present their goal-directed subgroup identification (GD-SI) framework, reconciling biological heterogeneity with clinical actionability, and offering a scalable infrastructure for precision trial design and personalized sepsis management.

A dipolar-passivation strategy enables all-perovskite tandem solar cells with a power conversion efficiency of over 30%.