Activation of stimulator of interferon genes is promising for initiating robust de novo T-cell responses, but biomechanics-mediated immune inhibitory pathways hinder the cytotoxicity of T cells against tumor cells. Here, the authors report redox-responsive supramolecular polyrotaxanes nanoformulations that augment anti-tumor T-cell killing by overcoming cancer-cell mechanical softness.
- Haifen Luo
- Jingqi Lv
- Zhen Yang
