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Low-temperature decomposition and insufficient plastic deformability are bottlenecks that limit the practical applications of nanograined Al alloys. Here the authors utilize a high density vacancies in combination with Sc microalloying to stabilize nanograined Al-Cu alloys.

Accuracy loss and slow speed affect the identification of compounds through matching of mass spectra using a large-scale spectral library. Here the authors use Word2vec spectral embedding and hierarchical navigable small-world graph to improve accuracy and speed of spectral matching on their own million-scale in-silico library.

Crystal structural and biochemical analysis of the chloroplast-localized Holliday junction (HJ) resolvase MOC1 in Zea mays reveals that ZmMOC1 uses a unique β-hairpin structure and a two-metal ion catalysis mechanism to recognize and cleave HJs.

The basis for the diverse peptide-binding modes and the G protein selectivity of peptide GPCRs remains elusive. Here, the authors offer a structural basis for allosteric-like agonism and G protein selectivity of a neuropeptide GPCR, galanin receptor.

Bacterial populations, programmed to self-assemble by adhesion of nanobody–antigen pairs, can be processed into living materials (LAMBA) that are scalable, self-healing and programmable through functionalization with diverse proteins.

Retinitis pigmentosa is the leading cause of inherited blindness worldwide. Here, the authors use exome sequencing to identify mutations in SLC7A14that may be linked to the disease, and provide functional support for the role of this gene in retinal development and visual function in mice and zebrafish.

Atomically dispersed Rh on N-doped carbon exhibits 28- and 67-fold enhancements compared with state-of-the-art Pd/C and Pt/C, despite the low activity of Rh/C. The Rh single atoms exhibit high tolerance to CO poisoning compared to Rh nanoparticles.

Developing large-scale flexible display technologies calls for new gate dielectric materials balancing the insulating property and molecular packing of organic semiconductors. Ji et al. synthesize a dielectric copolymer contributing with charge mobility of 5 cm² V⁻¹ s⁻¹ and low operating voltage of 3 V.

VEGF-A/VEGFR2 signaling is a key driver of endothelial cell migration during sprouting angiogenesis. Here Genet et al. show that endophilin A2 regulates these processes by mediating clathrin-independent VEGFR2 internalization.

The deconfined quantum critical point describing a continuous phase transition from a plaquette-singlet to an antiferromagnetic Néel phase in SrCu₂(BO₃)₂ has remained elusive. Here, the authors conduct high-pressure heat capacity measurements on the material providing experimental evidence indicating a first-order quantum phase transition between the two different symmetry-breaking phases.

Here the authors pull apart the cellular composition of the tumor microenvironment using RNA sequencing data from a wide variety of cancer types. They identify immunity quantitative trait loci and integrate these data with analysis of colorectal cancer cohorts, creating a polygenic risk score and a database for community access.

High-density, highly stable coherent nanoprecipitates are created in Al alloys that enable high strength and creep resistance at 400 °C. This is realized via a growth-ledge-triggered in situ phase transformation assembling slow-diffusing solutes with high-solubility solutes into nanoprecipitates.

Engineering metastability can enhance the ductility of alloys, but it often comes at an expense of relatively low yield strength. Here, the authors fabricate a Ti-based alloy with heterogeneous laminated structures and α-nanoprecipitates that enhance yield strength without sacrificing ductility.

It is challenging to obtain Ti alloys with ultrafine microstructure owing to the low thermal stability of crystallographic boundaries. Here the authors demonstrate a chemical boundary-based strategy to produce a hierarchical Ti alloy with nano-martensites that has excellent strength and ductility.

Male and female B cells show differing abilities to localize and contribute to germinal centres, in a way that depends on the G-protein-coupled guidance receptor GPR174 and its chemokine ligand CCL21.

This work achieves highly active and selective electrocatalytic hydrogenation of acetylene to ethylene (HAE) under mild conditions over Cu catalyst to replace the classic thermocatalytic HAE route requiring harsh conditions and costly H₂.

Regulation of Cu facets to promote electrocatalytic CO₂ reduction is interesting and challenging. Here the authors describe a deposition-etch-bombardment synthetic approach to prepare Cu(100)-rich thin film electrodes for CO₂ electroreduction with over 50% ethylene Faradaic efficiency at a total current of 12 A.

Here the authors demonstrate how the reaction selectivity of catalytic platinum nanowires can be controlled through surface modification with organic ligands.

Controlling localization of multiple metal nanoparticles on a single support is at the cutting edge of designing innovatory cascade catalysts. Here, the authors report a multicompartmentalized mesoporous organosilica to spatially position different metal nanoparticles in intimate proximity for efficient sequential hydrogenation reactions.

Most mutant p53 heterozygous tumours undergo loss of the remaining wildtype (WT) p53 allele which leads to stabilization of the mutant p53 protein. Here, the authors show in an autochthonous colorectal cancer model that the WT p53 allele retains partial activity and suppresses the heat shock factor 1 (HSF1)- chaperone axis to prevent mutant p53 stabilisation and mutant p53 gain-of-function activities, thereby creating selective pressure for p53 loss-of-heterozygosity.

The dynamics of droplet impact and splash is important in many applications, yet its analysis involves difficult intertwined aspects. Here Liu et al. make shape parametrically accessible to experiment, with ferrofluidic drops passing a magnetic field in a defined way.

Tumour associated macrophages (TAMs) have an altered lipid metabolism. Here the authors show that downregulation of monoacylglycerols lipase MGLL in TAMs induces lipid accumulation and tumor progression by polarizing TAMs toward tumor-promoting through activation of cannabinoid receptor CB2.

Skatole is a bacterial metabolite responsible for boar taint and the objectionable smell of manure. Here, the authors elucidate the final step of skatole biosynthesis, describing the discovery and biochemical characterization of the enzyme catalysing the conversion of indoleacetate into skatole.

Pericytes are perivascular cells that regulate blood vessel formation and function. Here Dubrac et al. show that pericyte recruitment contributes to pathological neovascularisation in a mouse model of ischemic retinopathy, and that this depends on the regulation of PDGF-B signaling by NCK adaptor proteins.

Cheng and colleagues performed an integrative analysis of human colorectal cancer samples to characterize the tumor microenvironment (TME) and stratify patients according to their heterogeneous TMEs, which exploit different immune evasion mechanisms.

Trp53 null and R270H mutations had comparable effects on tumor phenotypes in a genetically engineered mouse model of colorectal cancer (CRC). The mouse tumors with Trp53 null or R270H mutations as well as human CRCs with null or codon R273 missense mutations had similar gene expression profiles. These findings raise questions about a general role for gain-of-function effects for mutant p53 proteins in CRC.