Difluorocarbene, an important reactive intermediate in organic synthesis, exhibits intriguing properties and synthetic versatility. Herein, the authors report a copper catalyzed multicomponent reaction of amine, aldehyde and BrCF2CO2K via copper-difluorocarbene intermediate for the synthesis of multifunctional α-aminoamide derivatives.
- Jiuling Li
- Baofan Wang
- Zhenghui Kang
