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Association between cardiovascular health and overactive bladder

Zehao Li
Xiangliang Liu
Jiuwei Cui
ResearchOpen Access17 Feb 2025
Scientific Reports

Volume: 15, P: 1-8
Structure and regulation of ZCCHC4 in m⁶A-methylation of 28S rRNA

The N6-methyladenosine (m⁶A) RNA modification is an evolutionarily conserved epitranscriptomic mechanism that impacts several cellular processes. Here the authors present a structure-function analysis of the ZCCHC4, 28S RNA-specific m⁶A methyltransferase, shedding light on its regulation and mechanisms that ensure substrate specificity.

Wendan Ren
Jiuwei Lu
Jikui Song
ResearchOpen Access06 Nov 2019
Nature Communications

Volume: 10, P: 1-9
Comprehensive structure-function characterization of DNMT3B and DNMT3A reveals distinctive de novo DNA methylation mechanisms

In mammals, DNA methylation patterns are established by two de novo DNA methyltransferases, DNMT3A and DNMT3B. Here the authors report the crystal structures of DNMT3B in complex with both CpG and CpA DNA, providing insight into the substrate-recognition mechanism underpinning the divergent genomic methylation activities of DNMT3A and DNMT3B.

Linfeng Gao
Max Emperle
Jikui Song
ResearchOpen Access03 Jul 2020
Nature Communications

Volume: 11, P: 1-14
DNA sequence-dependent activity and base flipping mechanisms of DNMT1 regulate genome-wide DNA methylation

DNA methylation is one of the major epigenetic mechanisms that critically influence gene expression, genomic stability and cell differentiation. Here, the authors study DNMT1 in complex with DNA substrates and systematically analyze the mechanism and specificity of DNMT1.

Sabrina Adam
Hiwot Anteneh
Albert Jeltsch
ResearchOpen Access24 Jul 2020
Nature Communications

Volume: 11, P: 1-15
Structure of DNMT3B homo-oligomer reveals vulnerability to impairment by ICF mutations

In mammals, de novo DNA methyltransferase DNMT3B is essential for establishing DNA methylation patterns during embryonic development. Here the authors provide a structure-function characterization of homo-oligomeric DNMT3B, revealing the molecular basis for its vulnerability to ICF mutations.

Linfeng Gao
Yiran Guo
Jikui Song
ResearchOpen Access22 Jul 2022
Nature Communications

Volume: 13, P: 1-11
Lapsed El Niño impact on Atlantic and Northwest Pacific tropical cyclone activity in 2023

The impact of the 2023 strong El Niño event on North Atlantic and Northwest Pacific tropical cyclone activity was lapsed by the record-warm tropical North Atlantic, the record-breaking negative Pacific Meridional Mode, and background global warming.

Jiuwei Zhao
Ruifen Zhan
Mingrui Xu
ResearchOpen Access07 Aug 2024
Nature Communications

Volume: 15, P: 1-11
Structural basis for STAT2 suppression by flavivirus NS5

Cryo-EM, X-ray crystallography and mutational analyses reveal how Dengue and Zika virus protein NS5 suppresses STAT2 activity and interferon response in host cells.

Boxiao Wang
Stephanie Thurmond
Jikui Song
Research10 Aug 2020
Nature Structural & Molecular Biology

Volume: 27, P: 875-885
Disposable and flexible smart electronic tapes for long-term biopotential monitoring

Jiuwei Gao
Mingwei Hu
Wei Huang
ResearchOpen Access30 Jan 2025
npj Flexible Electronics

Volume: 9, P: 1-9
Toripalimab plus chemotherapy for first line treatment of advanced non-small cell lung cancer (CHOICE-01): final OS and biomarker exploration of a randomized, double-blind, phase 3 trial

Jia Zhong
Kailun Fei
Jie Wang
ResearchOpen Access24 Dec 2024
Signal Transduction and Targeted Therapy

Volume: 9, P: 1-9
Randomized, multicenter, open-label trial of autologous cytokine-induced killer cell immunotherapy plus chemotherapy for squamous non-small-cell lung cancer: NCT01631357

Liang Liu
Quanli Gao
Xiubao Ren
ResearchOpen Access19 Oct 2020
Signal Transduction and Targeted Therapy

Volume: 5, P: 1-3
Irinotecan hydrochloride liposome HR070803 in combination with 5-fluorouracil and leucovorin in locally advanced or metastatic pancreatic ductal adenocarcinoma following prior gemcitabine-based therapy (PAN-HEROIC-1): a phase 3 trial

Jiujie Cui
Shukui Qin
Liwei Wang
ResearchOpen Access19 Sept 2024
Signal Transduction and Targeted Therapy

Volume: 9, P: 1-9
Combined RNA-seq and RAT-seq mapping of long noncoding RNAs in pluripotent reprogramming

Zhonghua Du
Lin Jia
Ji-Fan Hu
ResearchOpen Access20 Nov 2018
Scientific Data

Volume: 5, P: 1-8

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