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Hypoxia induces ROS-resistant memory upon reoxygenation in vivo promoting metastasis in part via MUC1-C

Hypoxia is associated with metastasis and mortality. Here, the authors show that intratumoral hypoxia is linked to oxidative stress driving both HIF and NF-kB signaling to sustain a ROS-resistant phenotype that drives metastasis partially via MUC1-C.

Inês Godet
Harsh H. Oza
Daniele M. Gilkes
ResearchOpen Access28 Sept 2024
Nature Communications

Volume: 15, P: 1-19
CO confers neuroprotection via activating the PERK-calcineurin pathway and inhibiting necroptosis

Jeongmin Park
LiHua Jin
Hun Taeg Chung
ResearchOpen Access27 May 2025
Cell Death Discovery

Volume: 11, P: 1-16
An automated 13.5 hour system for scalable diagnosis and acute management guidance for genetic diseases

Rapid diagnosis and implementation of treatments is crucial in many genetic conditions. Here the authors describe Genome-to-Treatment, a virtual disease management system that can achieve a rapid diagnosis by expedited whole genome sequencing in 13.5 hours and provide guidance to clinicians for possible therapies.

Mallory J. Owen
Sebastien Lefebvre
Stephen F. Kingsmore
ResearchOpen Access26 Jul 2022
Nature Communications

Volume: 13, P: 1-14
A nuclear tRNA-derived fragment triggers immunity in Arabidopsis

An sRNA study in Arabidopsis reveals that a tRF drives immunity via DCL1 and AGO2, activating defense genes, suppressing Gypsy retrotransposons, and binding chromatin to coordinate transcriptional reprogramming in a sequence-dependent manner.

Sung-Il Kim
Haomin Lyu
Hong-Gu Kang
ResearchOpen Access01 Apr 2025
Communications Biology

Volume: 8, P: 1-12
CRISPR-mediated knockout of cardinal and cinnabar eye pigmentation genes in the western tarnished plant bug

Chan C. Heu
Roni J. Gross
Jeffrey A. Fabrick
ResearchOpen Access22 Mar 2022
Scientific Reports

Volume: 12, P: 1-12
Carbon monoxide-induced TFEB nuclear translocation enhances mitophagy/mitochondrial biogenesis in hepatocytes and ameliorates inflammatory liver injury

Hyo Jeong Kim
Yeonsoo Joe
Hun Taeg Chung
ResearchOpen Access17 Oct 2018
Cell Death & Disease

Volume: 9, P: 1-16

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Hypoxia induces ROS-resistant memory upon reoxygenation in vivo promoting metastasis in part via MUC1-C

CO confers neuroprotection via activating the PERK-calcineurin pathway and inhibiting necroptosis

An automated 13.5 hour system for scalable diagnosis and acute management guidance for genetic diseases

A nuclear tRNA-derived fragment triggers immunity in Arabidopsis

CRISPR-mediated knockout of cardinal and cinnabar eye pigmentation genes in the western tarnished plant bug

Carbon monoxide-induced TFEB nuclear translocation enhances mitophagy/mitochondrial biogenesis in hepatocytes and ameliorates inflammatory liver injury

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