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Showing 1–7 of 7 results
Advanced filters: Author: Johannes Zuegg Clear advanced filters

  • The inhibition of bacterial glycosyltransferase has the potential to be an effective therapeutic target against drug resistance bacteria. Here, the authors present a novel class of inhibitor compounds based on a monosaccharide scaffold, which are able to eliminate bacterial infections in mice.

    • Johannes Zuegg
    • Craig Muldoon
    • Matthew A. Cooper
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-11

  • Peptide antibiotics often display a very narrow therapeutic index. Here, the authors present an optimized peptide antibiotic with broad-spectrum in vitro activities, in vivo efficacy in multiple disease models against multidrug-resistant Gram-negative infections, and reduced toxicity.

    • Alysha G. Elliott
    • Johnny X. Huang
    • Matthew A. Cooper
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-13

  • The antibiotic vancomycin inhibits bacterial cell wall synthesis by binding to a membrane-associated precursor. Here, Blaskovich et al. synthesize vancomycin derivatives containing lipophilic peptide moieties that enhance membrane affinity and in vivo activities against glycopeptide-resistant strains.

    • Mark A. T. Blaskovich
    • Karl A. Hansford
    • Matthew A. Cooper
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-17

  • The PsaA binding protein delivers Mn2+ to the human pathogen Streptococcus pneumoniae. Structural and biochemical studies now explain its metal specificity, showing that metal binding induces a closed complex that is reversible for the desired substrate but irreversible for the inhibitor Zn2+.

    • Rafael M Couñago
    • Miranda P Ween
    • Christopher A McDevitt
    Research
    Nature Chemical Biology
    Volume: 10, P: 35-41

  • Metals and their complexes with antimicrobial activity are a promising source of new antibiotics. Their 3D geometry and potential for multiple mechanisms of action are important assets; however, a substantial investment in research is needed to advance them to the clinic.

    • Angelo Frei
    • Anthony D. Verderosa
    • Mark A. T. Blaskovich
    Reviews
    Nature Reviews Chemistry
    Volume: 7, P: 202-224

  • Blaskovich et al. demonstrate the antimicrobial applications of cannabidiol and cannabidiol analogs against a range of pathogenic bacteria, including the capacity to kill MRSA and the Gram-negative bacteria Neisseria gonorrhoeae. This article highlights the potential for cannabidiol in the age of antimicrobial resistance.

    • Mark A. T. Blaskovich
    • Angela M. Kavanagh
    • Michael Thurn
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-18