Nature Search

Large-scale mining of plant genomes unlocks the diversity of oxidosqualene cyclases

In plants, oxidosqualene cyclases (OSCs) perform a highly complex single reaction to generate the basis of all triterpenoid diversity. Here the authors leverage genome mining and transient expression to uncover multiple evolutionary and mechanistic insights for OSCs across the plant kingdom.

Michael J. Stephenson
Charlotte Owen
Anne Osbourn
ResearchOpen Access06 Oct 2025
Nature Chemical Biology

P: 1-11
Inhibition of epithelial cell YAP-TEAD/LOX signaling attenuates pulmonary fibrosis in preclinical models

Extracellular matrix (ECM) remodeling is a hallmark of fibrosis thought to be driven by mesenchymal cells. Here, the authors discover that YAP-TEAD/LOX axis is activated in distal lung epithelial cells, which contributes to ECM remodeling in pre-clinical models of pulmonary fibrosis.

Darcy Elizabeth Wagner
Hani N. Alsafadi
Melanie Königshoff
ResearchOpen Access02 Aug 2025
Nature Communications

Volume: 16, P: 1-20
Naturally-occurring cholesterol analogues in lipid nanoparticles induce polymorphic shape and enhance intracellular delivery of mRNA

Endosomal sequestration of lipid-based nanoparticles is a barrier to delivery of nucleic acids. Here the authors test an array of cholesterol variants and perform in-depth investigation of nanoparticle shape, internal structure and intracellular trafficking.

Siddharth Patel
N. Ashwanikumar
Gaurav Sahay
ResearchOpen Access20 Feb 2020
Nature Communications

Volume: 11, P: 1-13
Characterising acute and chronic care needs: insights from the Global Burden of Disease Study 2019

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

Cecilia Anza-Ramirez
J. Jaime Miranda
Yves Miel H. Zuniga
ResearchOpen Access07 May 2025
Nature Communications

Volume: 16, P: 1-36
A single-cell rice atlas integrates multi-species data to reveal cis-regulatory evolution

This study maps chromatin accessibility at single-cell resolution in rice and related grasses, revealing how regulatory DNA elements evolve across cell types and species and identifying potential silencers that control gene expression.

Haidong Yan
John P. Mendieta
Robert J. Schmitz
ResearchOpen Access17 Sept 2025
Nature Plants

P: 1-22
Towards fair decentralized benchmarking of healthcare AI algorithms with the Federated Tumor Segmentation (FeTS) challenge

Federated learning (FL) algorithms have emerged as a promising solution to train models for healthcare imaging across institutions while preserving privacy. Here, the authors describe the Federated Tumor Segmentation (FeTS) challenge for the decentralised benchmarking of FL algorithms and evaluation of Healthcare AI algorithm generalizability in real-world cancer imaging datasets.

Maximilian Zenk
Ujjwal Baid
Spyridon Bakas
ResearchOpen Access08 Jul 2025
Nature Communications

Volume: 16, P: 1-20
Novel VCAN mutations and evidence for unbalanced alternative splicing in the pathogenesis of Wagner syndrome

Barbara Kloeckener-Gruissem
John Neidhardt
Wolfgang Berger
Research27 Jun 2012
European Journal of Human Genetics

Volume: 21, P: 352-356
The Correlation between Sleep and Creativity

Valeria Drago
Debora Aricò
Raffaele Ferri
ResearchOpen Access09 Mar 2010
Nature Precedings

P: 1
Neural computations of threat in the aftermath of combat trauma

PTSD symptom severity in combat veterans was associated with enhanced sensitivity to prediction errors and lower neural tracking of value and learning rate, providing evidence for neurocomputational contributions to trauma-related psychopathology.

Philipp Homan
Ifat Levy
Daniela Schiller
Research21 Jan 2019
Nature Neuroscience

Volume: 22, P: 470-476
Frequency-dependent decoupling of domain-wall motion and lattice strain in bismuth ferrite

Conductive domain walls of ferroelectric materials are considered for device applications demanding a fundamental understanding of their dynamics. Here, frequency-dependent decoupling of strains upon electric field cycling in BiFeO₃ is demonstrated to arise from conductive domain walls.

Lisha Liu
Tadej Rojac
John Daniels
ResearchOpen Access22 Nov 2018
Nature Communications

Volume: 9, P: 1-10
Stickler syndrome: Correlation between vitreoretinal phenotypes and linkage to COL 2A1

Martin P Snead
Stewart J Payne
John D Scott
Research01 Nov 1994
Eye

Volume: 8, P: 609-614
Structure of southern bean mosaic virus at 2.8 Å resolution

Celerino Abad-Zapatero
Sherin S. Abdel-Meguid
Tomitake Tsukihara
Research03 Jul 1980
Nature

Volume: 286, P: 33-39
Machine learning in Alzheimer’s disease genetics

Here the authors apply machine learning approaches to Alzheimer’s genetics, confirm known associations and suggest novel risk loci. These methods demonstrate predictive power comparable to traditional approaches, while also offering potential new insights beyond standard genetic analyses.

Matthew Bracher-Smith
Federico Melograna
Valentina Escott-Price
ResearchOpen Access22 Jul 2025
Nature Communications

Volume: 16, P: 1-16
Biological Half-lives of the Antibiotic Lincomycin Observed in Repetitive Experiments in the same Subjects

JOHN G. WAGNER
J. I. NORTHAM
W. T. SOKOLSKI
Research10 Jul 1965
Nature

Volume: 207, P: 201-202
The landscape of viral associations in human cancers

Viral pathogen load in cancer genomes is estimated through analysis of sequencing data from 2,656 tumors across 35 cancer types using multiple pathogen-detection pipelines, identifying viruses in 382 genomic and 68 transcriptome datasets.

Marc Zapatka
Ivan Borozan
Christian von Mering
ResearchOpen Access05 Feb 2020
Nature Genetics

Volume: 52, P: 320-330
Genome-wide association study of long COVID

A genome-wide study by the Long COVID Host Genetics Initiative identifies an association between the FOXP4 locus and long COVID, implicating altered lung function in its pathophysiology.

Vilma Lammi
Tomoko Nakanishi
Hanna M. Ollila
ResearchOpen Access21 May 2025
Nature Genetics

Volume: 57, P: 1402-1417
Mechanism of colour discrimination by a bacterial sensory rhodopsin

John L. Spudich
Roberto A. Bogomolni
Research06 Dec 1984
Nature

Volume: 312, P: 509-513
Herpesvirus vector gene transfer and expression of β–glucuronidase in the central nervous system of MRS VII mice

John H. Wolfe
Satish L. Deshmane
Nigel W. Fraser
Research01 Aug 1992
Nature Genetics

Volume: 1, P: 379-384
Saturated platelets are new intermediates in hydrocarbon pyrolysis and carbon formation

John Abrahamson
Research24 Mar 1977
Nature

Volume: 266, P: 323-327
Measuring flood underinsurance in the USA

Homeowners could benefit from flood insurance to offset the negative impacts of climate-induced natural disasters. However, with detailed micro-level data, researchers find substantial protection gaps and underinsurance across the USA that disproportionately affect low-income households.

Natee Amornsiripanitch
Siddhartha Biswas
David Zink
Research15 Aug 2025
Nature Climate Change

Volume: 15, P: 971-977
Genome-wide analyses identify 30 loci associated with obsessive–compulsive disorder

Genome-wide analyses identify 30 independent loci associated with obsessive–compulsive disorder, highlighting genetic overlap with other psychiatric disorders and implicating putative effector genes and cell types contributing to its etiology.

Nora I. Strom
Zachary F. Gerring
Manuel Mattheisen
ResearchOpen Access13 May 2025
Nature Genetics

Volume: 57, P: 1389-1401
Mapping the evolution of hierarchical microstructures in a Ni-based superalloy

Phase separation in nickel-based superalloys is known to be complex and to determine the resulting microstructure and mechanical properties. Here, the authors use atom probe tomography to study phase development, finding that nickel concentration is critical in driving the formation of the γ phase from γ′.

Florian Vogel
Nelia Wanderka
John Banhart
Research20 Dec 2013
Nature Communications

Volume: 4, P: 1-7
The genomic history of Iberian horses since the last Ice Age

Horses have lived in Iberia since the Ice Age. Using ancient genomes to study their history, Lira Garrido et al. reveal a local wild lineage lasting until Late Iron Age, and highlight the far-reaching influence of Iberian bloodlines across Europe and north Africa during the Iron Age and beyond.

Jaime Lira Garrido
Gaétan Tressières
Ludovic Orlando
ResearchOpen Access02 Aug 2025
Nature Communications

Volume: 16, P: 1-14
Global impoverishment of natural vegetation revealed by dark diversity

A comparison of alpha diversity (number of plant species) and dark diversity (species that are currently absent from a site despite being ecologically suitable) demonstrates the negative effects of regional-scale anthropogenic activity on plant diversity.

Meelis Pärtel
Riin Tamme
Martin Zobel
ResearchOpen Access02 Apr 2025
Nature

Volume: 641, P: 917-924
The development of intramedullary cavitation following spinal cord injury: an experimental pathological study

Franklin C Wagner
John C Van Gilder
George J Dohrmann
Research01 Feb 1977
Spinal Cord

Volume: 14, P: 245-250
Genome sequencing is critical for forecasting outcomes following congenital cardiac surgery

The authors use artificial intelligence approaches to explore the predictive value of whole exome sequencing in forecasting clinical outcomes following surgery for congenital heart defects. Findings include that damaging genotypes in chromatin-modifying and cilia-related genes are associated with an increased risk of adverse post-operative outcomes such as mortality, cardiac arrest, and prolonged mechanical ventilation.

W. Scott Watkins
Edgar J. Hernandez
Martin Tristani-Firouzi
ResearchOpen Access10 Jul 2025
Nature Communications

Volume: 16, P: 1-11
The effect of parenteral vitamin B₁₂ treatment on its plasma metabolomic profile and on functional biomarkers of its deficiency

Sarita Devi
Roshni M. Pasanna
Anura V. Kurpad
ResearchOpen Access05 Jul 2025
Scientific Reports

Volume: 15, P: 1-20
Biphenyl Group in Lignin

JOHN C. PEW
Research20 Jan 1962
Nature

Volume: 193, P: 250-252
Dominant variants in major spliceosome U4 and U5 small nuclear RNA genes cause neurodevelopmental disorders through splicing disruption

Analysis of snRNA genes in individuals with rare disorders identifies de novo and recurrent variants in RNU5B-1 and RNU5A-1, in addition to previously unreported cases with pathogenic or likely pathogenic variants in RNU4-2.

Caroline Nava
Benjamin Cogne
Christel Depienne
ResearchOpen Access16 May 2025
Nature Genetics

Volume: 57, P: 1374-1388
Synaptic enrichment of pSer129 alpha-synuclein correlates with dopaminergic denervation in early-stage Parkinson’s disease

α-Synuclein accumulation in putaminal synapses is hypothesised to drive Parkinson’s disease progression. This study demonstrates synaptic pSer129 α-synuclein enrichment in early-stage Parkinson’s disease, and its link with dopaminergic denervation and cortical Lewy body pathology.

Irene Frigerio
Martino L. Morella
Wilma DJ van de Berg
ResearchOpen Access18 Jul 2025
Nature Communications

Volume: 16, P: 1-19
Human neuromaturation, juvenile extreme energy liability, and adult cognition/cooperation

John Skoyles
ResearchOpen Access02 Apr 2012
Nature Precedings

P: 1
Observation of charge–parity symmetry breaking in baryon decays

The LHCb experiment at CERN has observed significant asymmetries between the decay rates of the beauty baryon and its CP-conjugated antibaryon, thus demonstrating CP violation in baryon decays.

R. Aaij
A. S. W. Abdelmotteleb
G. Zunica
ResearchOpen Access16 Jul 2025
Nature

Volume: 643, P: 1223-1228
Pervasive conformational fluctuations on microsecond time scales in a fibronectin type III domain

Mikael Akke
Jun Liu
Arthur G. Palmer III
Research01 Jan 1998
Nature Structural Biology

Volume: 5, P: 55-59
Latent Period of Vesicular Stomatitis Virus in Chick Embryo Cells

DAVID PITTMAN
RALPH C. St. JOHN
ISAAC L. SHECHMEISTER
Research19 Jun 1965
Nature

Volume: 206, P: 1228-1231
New insights into the genetic etiology of Alzheimer’s disease and related dementias

Meta-analysis of genome-wide association studies on Alzheimer’s disease and related dementias identifies new loci and enables generation of a new genetic risk score associated with the risk of future Alzheimer’s disease and dementia.

Céline Bellenguez
Fahri Küçükali
Jean-Charles Lambert
ResearchOpen Access04 Apr 2022
Nature Genetics

Volume: 54, P: 412-436
Two ears and two eyes

John D. Pettigrew
News & Views26 Aug 1993
Nature

Volume: 364, P: 756-757
Discrete Potentials in the Dark-adapted Eye of the Crab Limulus

JOHN E. DOWLING
Research06 Jan 1968
Nature

Volume: 217, P: 28-31
Next-generation phenotyping of inherited retinal diseases from multimodal imaging with Eye2Gene

Eye2Gene’s next-generation phenotyping of multimodal images increases diagnostic yield for inherited retinal diseases by improving screening, phenotype-driven variant prioritization and automatic similarity matching in phenotypic space to drive gene discovery.

Nikolas Pontikos
William A. Woof
Michel Michaelides
ResearchOpen Access18 Jun 2025
Nature Machine Intelligence

Volume: 7, P: 967-978
Hypergammaglobulinæmia in Mink initiated by a Cell-free Filtrate

JAMES B. HENSON
JOHN R. GORHAM
ROBERT W. LEADER
Research12 Jan 1963
Nature

Volume: 197, P: 206-207
Mangiferin and Other Glycophenolics in Iris Species

E. C. BATE-SMITH
J. B. HARBORNE
Research29 Jun 1963
Nature

Volume: 198, P: 1307-1308
Human generalization of internal representations through prototype learning with goal-directed attention

The authors use three latent-state learning tasks to test how people approximate the complexities of the external world with simplified internal representations that generalize to novel examples or situations. They show that behaviour can be captured by a model combining prototype representations with goal-oriented discriminative attention.

Warren Woodrich Pettine
Dhruva Venkita Raman
John D. Murray
Research09 Mar 2023
Nature Human Behaviour

Volume: 7, P: 442-463
Laterality Effects in Dichotic Listening

SUSAN OXBURY
JOHN OXBURY
JANE GARDINER
Research13 May 1967
Nature

Volume: 214, P: 742-743
The Platinum Group Metals in South Africa

JOHN PARKINSON
Books & Arts03 May 1930
Nature

Volume: 125, P: 662-663
Endogenous dynorphins inhibit excitatory neurotransmission and block LTP induction in the hippocampus

John J. Wagner
Gregory W. Terman
Charles Chavkin
Research03 Jun 1993
Nature

Volume: 363, P: 451-454
Nucleotide sequence and amplification in bacteria of structural gene for rat growth hormone

Peter H. Seeburg
John Shine
Howard M. Goodman
Research08 Dec 1977
Nature

Volume: 270, P: 486-494
Changing the identity of a transfer RNA

Jennifer Normanly
Richard C. Ogden
John Abelson
Research15 May 1986
Nature

Volume: 321, P: 213-219
Genetic non-responsiveness of murine fibroblasts to bacterial endotoxin

JOHN L. RYAN
KEITH P. W. J. MCADAM
Research01 Sept 1977
Nature

Volume: 269, P: 153-155
Statistical Modeling of Epistasis and Linkage Decay using Logic Regression

Thomas Parker
Peter Szucs
John Henning
ResearchOpen Access20 Nov 2008
Nature Precedings

P: 1
Incomplete remyelination via therapeutically enhanced oligodendrogenesis is sufficient to recover visual cortical function

Remyelination can restore neural function. Here, the authors characterize the drivers and limits of endogenous remyelination and explore a therapy that rescued remyelination deficits and accelerated neuronal functional recovery, although complete remyelination was not required.

Gustavo Della-Flora Nunes
Lindsay A. Osso
Ethan G. Hughes
ResearchOpen Access16 Jan 2025
Nature Communications

Volume: 16, P: 1-22
Transcriptional autoregulation of the proto-oncogene fos

Paolo Sassone-Corsi
John C. Sisson
Inder M. Verma
Research01 Jul 1988
Nature

Volume: 334, P: 314-319

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