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Showing 1–50 of 97 results
Advanced filters: Author: John O. Mack Clear advanced filters
  • A study reports whole-genome sequences for 490,640 participants from the UK Biobank and combines these data with phenotypic data to provide new insights into the relationship between human variation and sequence variation.

    • Keren Carss
    • Bjarni V. Halldorsson
    • Ole Schulz-Trieglaff
    ResearchOpen Access
    Nature
    Volume: 645, P: 692-701
  • The post-resolution phase of inflammation is not simply a linear path towards cessation of immune response but rather a regulated process involving fluctuating immune activity. Here authors show a pivotal role for post-resolution macrophages in driving a wave of T cell recruitment and activation via prostaglandin E2 and α-integrin signalling during the resolution phase of murine pneumococcal pneumonia.

    • Karen T. Feehan
    • Hannah E. Bridgewater
    • Derek W. Gilroy
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-17
  • Using data from a single time point, passenger-approximated clonal expansion rate (PACER) estimates the fitness of common driver mutations that lead to clonal haematopoiesis and identifies TCL1A activation as a mediator of clonal expansion.

    • Joshua S. Weinstock
    • Jayakrishnan Gopakumar
    • Siddhartha Jaiswal
    Research
    Nature
    Volume: 616, P: 755-763
  • The LHCb experiment at CERN has observed significant asymmetries between the decay rates of the beauty baryon and its CP-conjugated antibaryon, thus demonstrating CP violation in baryon decays.

    • R. Aaij
    • A. S. W. Abdelmotteleb
    • G. Zunica
    ResearchOpen Access
    Nature
    Volume: 643, P: 1223-1228
  • Phylogenomic analysis of 7,923 angiosperm species using a standardized set of 353 nuclear genes produced an angiosperm tree of life dated with 200 fossil calibrations, providing key insights into evolutionary relationships and diversification.

    • Alexandre R. Zuntini
    • Tom Carruthers
    • William J. Baker
    ResearchOpen Access
    Nature
    Volume: 629, P: 843-850
  • Soapwort (Saponaria officinalis) is a rich reservoir of triterpenoid glycosides that often have important pharmaceutical, nutraceutical and agronomical potential. Here, the authors elucidate the complete biosynthetic pathway of saponarioside B, a major saponin constituent in soapwort.

    • Seohyun Jo
    • Amr El-Demerdash
    • Anne Osbourn
    ResearchOpen Access
    Nature Chemical Biology
    Volume: 21, P: 215-226
    • John Hodgson
    Research
    Bio/Technology
    Volume: 9, P: 926-928
  • It remains unclear whether exotic and native species are functionally different. Using a global grassland experiment, Seabloomet al. show that native and exotic species respond differently to two globally pervasive environmental changes, addition of mineral nutrients and alteration of herbivore density.

    • Eric W. Seabloom
    • Elizabeth T. Borer
    • Louie Yang
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-8
  • Jimenez et al. show that CD40 agonists can induce myocardial inflammation by activating cardiac macrophages and CD8+ T cells, sensitizing the heart to secondary injury and promoting adverse remodeling.

    • Jesus Jimenez
    • Junedh Amrute
    • Kory J. Lavine
    Research
    Nature Cardiovascular Research
    Volume: 4, P: 458-472
  • Many animals, including mammals and insects, like slightly acidic yet dislike highly acidic foods, but how animals discriminate low from high acidity is unclear. Here the authors demonstrate that the fruit fly uses an evolutionarily conserved taste receptor to distinguish low from high concentrations of acid.

    • Tingwei Mi
    • John O. Mack
    • Yali V. Zhang
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-13
  • A study of the evolution of the SARS-CoV-2 virus in England between September 2020 and June 2021 finds that interventions capable of containing previous variants were insufficient to stop the more transmissible Alpha and Delta variants.

    • Harald S. Vöhringer
    • Theo Sanderson
    • Moritz Gerstung
    ResearchOpen Access
    Nature
    Volume: 600, P: 506-511
  • Chronic infection with SARS-CoV-2 leads to the emergence of viral variants that show reduced susceptibility to neutralizing antibodies in an immunosuppressed individual treated with convalescent plasma.

    • Steven A. Kemp
    • Dami A. Collier
    • Ravindra K. Gupta
    Research
    Nature
    Volume: 592, P: 277-282
  • Sera from vaccinated individuals and some monoclonal antibodies show a modest reduction in neutralizing activity against the B.1.1.7 variant of SARS-CoV-2; but the E484K substitution leads to a considerable loss of neutralizing activity.

    • Dami A. Collier
    • Anna De Marco
    • Ravindra K. Gupta
    Research
    Nature
    Volume: 593, P: 136-141
  • The authors identify a high-pH-activated chloride channel as a taste receptor responsible for the avoidance of alkaline foods in fruit flies, laying the groundwork for future research on alkaline taste sensation in other animals.

    • Tingwei Mi
    • John O. Mack
    • Yali V. Zhang
    Research
    Nature Metabolism
    Volume: 5, P: 466-480
  • At least two-thirds of supratentorial ependymomas contain oncogenic fusions between RELA, the principal effector of nuclear factor-κB (NF-κB) signalling, and uncharacterized gene C11orf95; C11orf95–RELA fusion proteins translocate spontaneously to the nucleus to activate NF-κB target genes, and rapidly transform neural stem cells to form tumours in mice

    • Matthew Parker
    • Kumarasamypet M. Mohankumar
    • Richard J. Gilbertson
    Research
    Nature
    Volume: 506, P: 451-455
  • The Omicron variant evades vaccine-induced neutralization but also fails to form syncytia, shows reduced replication in human lung cells and preferentially uses a TMPRSS2-independent cell entry pathway, which may contribute to enhanced replication in cells of the upper airway. Altered fusion and cell entry characteristics are linked to distinct regions of the Omicron spike protein.

    • Brian J. Willett
    • Joe Grove
    • Emma C. Thomson
    ResearchOpen Access
    Nature Microbiology
    Volume: 7, P: 1161-1179
  • The genome of the model fern species Ceratopteris richardii reveals a history of remarkably dynamic genome evolution, including rapid changes in genome content and structure following the most recent whole-genome duplication approximately 60 million years ago.

    • D. Blaine Marchant
    • Guang Chen
    • Zhong-Hua Chen
    ResearchOpen Access
    Nature Plants
    Volume: 8, P: 1038-1051
  • Medulloblastoma is the most common malignant brain tumour in children; having assembled over 1,000 samples the authors report that somatic copy number aberrations are common in medulloblastoma, in particular a tandem duplication of SNCAIP, a gene associated with Parkinson’s disease, which is restricted to subgroup 4α, and translocations of PVT1, which are restricted to Group 3.

    • Paul A. Northcott
    • David J. H. Shih
    • Michael D. Taylor
    ResearchOpen Access
    Nature
    Volume: 488, P: 49-56
  • The results obtained by seventy different teams analysing the same functional magnetic resonance imaging dataset show substantial variation, highlighting the influence of analytical choices and the importance of sharing workflows publicly and performing multiple analyses.

    • Rotem Botvinik-Nezer
    • Felix Holzmeister
    • Tom Schonberg
    Research
    Nature
    Volume: 582, P: 84-88
  • A comparison of the structures of two cyanobacterial toxins yields insights into how they may inhibit protein phosphatase-1 and -2A and why microcystins but not motuporin may covalently modify their protein phosphatase targets.

    • John R. Bagu
    • Frank D. Sönnichsen
    • Charles F.B. Holmes
    Correspondence
    Nature Structural Biology
    Volume: 2, P: 114-116
  • Sweetpotato is an important food security crop providing rich source of macro- and micronutrients including carbohydrates and vitamins. Here, the authors assemble of the two diploid relatives of cultivated sweetpotato and identify genes and alleles associated with carotenoid biosynthesis from breeding lines.

    • Shan Wu
    • Kin H. Lau
    • Zhangjun Fei
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-12
  • The Somatic Mosaicism across Human Tissues Network aims to create a reference catalogue of somatic mosaicism across different tissues and cells within individuals.

    • Tim H. H. Coorens
    • Ji Won Oh
    • Yuqing Wang
    Reviews
    Nature
    Volume: 643, P: 47-59
  • Modulation of the spin states of molecules adsorbed on metal surfaces facilitates potential spintronic applications. Here, the authors demonstrate the tuning of the electronic interaction between a gold surface and the ligand of a corrole complex, tuning its spin state through fused-ring-expansion.

    • Fan Wu
    • Jie Liu
    • Zhen Shen
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-8
  • The One Thousand Plant Transcriptomes Initiative provides a robust phylogenomic framework for examining green plant evolution that comprises the transcriptomes and genomes of diverse species of green plants.

    • James H. Leebens-Mack
    • Michael S. Barker
    • Gane Ka-Shu Wong
    ResearchOpen Access
    Nature
    Volume: 574, P: 679-685
  • Sequencing data from the developing cerebellum are compared with bulk sequencing data from paediatric tumours, providing insights into their potential origins and suggesting that many cerebellar tumours have their origins early in utero.

    • Maria C. Vladoiu
    • Ibrahim El-Hamamy
    • Michael D. Taylor
    Research
    Nature
    Volume: 572, P: 67-73
  • Breaking down the endothelial barrier is a hallmark of systemic inflammatory response syndrome. Here the authors show that palmitoylation, a post-translational modification of proteins, plays a critical role in altering endothelial function during inflammation, and suggest the targeting of palmitoyl acyltransferase DHHC21 as potential disease therapy.

    • Richard S. Beard Jr.
    • Xiaoyuan Yang
    • Sarah Y. Yuan
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-19
  • To address the question of whether a recurrent tumour is genetically similar to the tumour at diagnosis, the evolution of medulloblastoma has been studied in both an in vivo mouse model of clinical tumour therapy as well as in humans with recurrent disease; targeted tumour therapies are usually based on targets present in the tumour at diagnosis but the results from this study indicate that post-treatment recurring tumours (compared with the tumour at diagnosis) have undergone substantial clonal divergence of the initial dominant tumour clone.

    • A. Sorana Morrissy
    • Livia Garzia
    • Michael D. Taylor
    Research
    Nature
    Volume: 529, P: 351-357
  • Analysis of changes in functional groups of species and potential drivers of environmental change for protected areas across the world’s major tropical regions reveals large variation between reserves that have been effective and those experiencing an erosion of biodiversity, and shows that environmental changes immediately outside reserves are nearly as important as those inside in determining their ecological fate.

    • William F. Laurance
    • D. Carolina Useche
    • Franky Zamzani
    Research
    Nature
    Volume: 489, P: 290-294
  • Infection with SARS-CoV2 and the development of Coronavirus disease 2019 (COVID-19) has been linked to induction of autoimmunity and autoantibody production. Here the authors characterise the new-onset IgG autoantibody response in hospitalised patients with COVID-19 which they correlate to the magnitude of the SARS-CoV2 response.

    • Sarah Esther Chang
    • Allan Feng
    • Paul J. Utz
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-15