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The discovery of a vast reservoir of primordial neutral hydrogen gas surrounding a young galaxy cluster just one billion years after the Big Bang offers new insight into how the first large cosmic structures assembled.

Lithium tantalate is heterogeneously integrated with silicon photonic integrated circuits via a micro-transfer printing process in a manner fully compatible with existing workflows. A Mach–Zehnder modulator with an insertion loss of 2.9 dB and 70 GHz operation is demonstrated.

The combination of JWST and ALMA data here unravel the history of the gas content of a quiescent galaxy, which became quenched through an act of self-sabotage. Black-hole accretion feedback heated the galaxy’s surrounding material, preventing its accretion.

Electron spins in diamond allow magnetometry with high sensitivity, but the bandwidth in the microwave regime is limited to a narrow band around their resonance frequency. Here, the authors solve this problem by coupling the spins to a thin film of yttrium iron garnet, exploiting the non-linear spin-wave dynamics of the magnet.

Scanning tunneling microscope (STM) is a powerful tool but local control of superconductivity with the STM tip is still lacking. Here, Geet al. show the use of an STM tip to control the local pinning in a superconductor through the heating effect, allowing to manipulate single superconducting vortex at nanoscale.

An 11-qubit atom processor comprising two precision-placed nuclear spin registers of phosphorus in silicon is shown to achieve state-of-the-art Bell-state fidelities of up to 99.5%.

Studies of biomarkers of aging encounter a range of epidemiological and methodological challenges, many of which are not fully acknowledged. In this Comment, we critically examine key challenges and suggest strategies to address them.

Suspended sediment currents travel through channels on the ocean floor to deliver enormous volumes of sediment to the deep ocean. Here, using a new approach for scaled laboratory experiments, the authors show how feedback between these currents and their deposits drive the formation of these submarine channels.

Long quantum coherence time is a fundamental requirement for the realization of any quantum-mechanically operating machine. Here, Bader et al.demonstrate a coherence time as long as 68 μs at low temperature and of 1 μs at room temperature for a transition metal complex.

Through next-generation spectral analysis, scientists have uncovered an evolutionary path for Wolf–Rayet stars in metal-poor environments. Characterized by hard ionizing radiation, these stars challenge current assumptions about massive star evolution.

How do low-mass binaries age? Astronomers have constrained a tight, circular orbit of a close-in companion around a dying giant star, raising new questions about how tidal forces shape binary orbits in the final phases of stellar evolution.

Hydrogen peroxide is a signaling molecule that can also cause damage if its levels are too high. Here, the authors report HyPerFLEX, a fluorescent sensor with tenable colors, to track very low peroxide levels in cellular organelles, even in low-oxygen or highly oxidizing environments.

Around 42% of the digital industry’s embodied emissions was assigned to other sectors’ supply chains in 2021 due to limitations in conventional greenhouse gas accounting methods, according to global input-output data analyses.

Four-coordinate cobalt(II) complexes possess high energy barriers toward inversion of the magnetic moment, but not the magnetic bistability needed for magnetic data storage. Here, the authors report an air-stable radical-bridged binuclear cobalt(II) complex with improved magnetic properties.

Phase-coherent frequency combs in the mid-infrared have important potential applications but their fabrication remains challenging. Here, Kuyken et al. demonstrate an octave-spanning frequency comb in the mid-infrared using a highly nonlinear dispersion-engineered silicon waveguide on a silicon-on-insulator chip.

A new integration approach, nano-ridge engineering, enables electrically driven GaAs-based laser diodes to be fabricated on Si wafers in a complementary metal–oxide–semiconductor (CMOS) pilot line, showing potential for the integration of laser diodes in a Si photonics platform.

Multi-donor molecules in Si provide a promising qubit platform, offering advantages over single donor qubits in terms of performance and fabrication. Here, the authors report a single qubit gate and long coherence times in a P donor molecule qubit in natural Si patterned by scanning tunneling microscope hydrogen lithography.

Liquid crystal networks can morph their shape in response to electrical stimulus. Here the authors provide a detailed description of their deformation mechanism and introduce a method to observe the dynamic surface of liquid crystal elastomers. This could help with the development of smart materials.

Cyclopentadienyl ligands are central to organometallic lanthanide chemistry as their electron-donating ability enables fine-tuning for various applications including catalysis, luminescent materials, and single molecule magnets. Here, the authors report the synthesis and characterization of the lanthanide complexes featuring η⁵-coordinating heterocyclic stibolyl and bismolyl ligands.

Immune checkpoint blockade has become standard care for patients with recurrent metastatic head and neck squamous cell carcinoma (HNSCC). Here the authors present the results of a non-randomized phase Ib/IIa trial, reporting safety and efficacy of neoadjuvant nivolumab monotherapy and nivolumab plus ipilimumab prior to standard-of-care surgery in patients with HNSCC. .

Efficient gas bubble removal is crucial for high-rate water electrolysis aimed at optimizing hydrogen production. Here, the authors show that integrating 3-D foam electrodes into a specially designed cell configuration enables alkaline water electrolysis to perform comparably to advanced systems, thereby enhancing overall efficiency.

In the Kondo effect, a bath of conduction electrons screens a localized magnetic moment. Here, the authors demonstrate Kondo screening of a normally isolated 4f-like moment in a magnetic molecule on a Cu(001) surface that is modulated by strong ligand-mediated coupling.

Rizzollo et al. show that BDH2 participates in iron distribution between cellular compartments, which sets the threshold for the ferroptosis vulnerability of the melanoma cell phenotypes, ultimately affecting their metastatic capacity

Early stellarator designs suffered from high particle losses, an issue that can be addressed by optimization of the coils. Here the authors measure the magnetic field lines in the Wendelstein 7-X stellarator, confirming that the complicated design of the superconducting coils has been realized successfully.

Spectroscopy from the JWST Advanced Deep Extragalactic Survey of a galaxy at redshift 13 shows a singular, bright emission line identified as Lyman-α, suggesting the onset of reionization only 330 Myr after the Big Bang.

NADH and NAD+ act as electron donors and acceptors and NAD+ was shown to stimulate mitochondrial biogenesis and metabolic health. Here, the researchers developed and validated a non-invasive Phosphorous Magnetic Resonance Spectroscopy method to non-invasively quantify NAD+ and NADH in muscle on a clinical 3 T MRI scanner.

Modelling magnetic data for lanthanide clusters is challenging due to spin–orbit coupling and crystal field effects. Here, the authors use multi-frequency electron paramagnetic resonance spectroscopy to measure directly the interaction between two dysprosium(III) ions in a dimeric system.

Large 3D electron microscopy data sets frequently contain noisy data due to accelerated imaging, and denoising techniques require specialised skill sets. Here the authors introduce DenoisEM, an ImageJ plugin that democratises denoising EM data sets, enabling fast parameter tuning and processing through parallel computing.

A dormant supermassive black hole at high redshift that is substantially overmassive relative to its host galaxy has been detected, indicating a much larger population of dormant black holes around the epoch of reionization.

ATG8ylation of the tonoplast, triggered by cell wall damage, acts as a vital vacuolar quality control mechanism that safeguards vacuolar integrity and ensures cell survival under stress.

Bistable single-molecule magnets potentially allow information storage at extremely high densities. Here, the authors study an air- and moisture-stable mononuclear tetrahedral cobalt(II) complex, elucidating the origin of its pronounced magnetic bistability.

β2-agonist treatment improves skeletal muscle glucose uptake and whole-body glucose homeostasis in rodents. Here the authors report that two-weeks of treatment with the β2-agonist clenbuterol improves insulin-stimulated glucose disposal in healthy young men in a double-blinded, randomized cross-over trial.

Studying the spin lifetime anisotropy in graphene, which provides information on spin-orbit interaction and is relevant to spintronic applications, poses important experimental challenges. Here, the authors study the spin lifetime anisotropy using spin precession under oblique magnetic fields.

This article presents NAPstars, a family of genetically-encoded biosensors that enable real-time monitoring of NADP redox dynamics across species. The sensors reveal robust NADP redox regulation, cell-cycle-linked NADP oscillations, and glutathione as the major conduit for anti-oxidative electron flux.

Intestinal tuft cell subtypes represent successive stages of differentiation that is driven by crypt-villus signaling gradients. Here, the authors show that applying these gradients to organoids generates mature immune-related chemosensory tuft cells suitable for experimental studies.

The superconducting proximity effect has not been experimentally demonstrated in a quantum anomalous Hall insulator. Now this effect is observed in the chiral edge state of a ferromagnetic topological insulator.

Gkioni et al. show that trametinib, which targets the Ras–Mek–Erk pathway, extends lifespan in male and female mice and that co-treatment with the known geroprotector rapamycin additively extends lifespan and healthspan, reducing inflammation and tumor growth.

Single-molecule magnets could be useful for the development of spintronic devices. Here single-molecule magnets are encapsulated in carbon nanotubes without affecting the properties of the guest molecules, which may be useful in the development of spintronic or high-density magnetic storage devices.

Increased neuronal activity and reduced sleep quality emerge in the early stages of Alzheimer’s disease (AD). Calafate et al. show that the sleep–active hypothalamic MCH system is involved in neuronal homeostasis but fails in the early stages of AD.

The authors report the photometric detection of the distant spectroscopically confirmed galaxy JADES-GS-z14-0 at z > 14 with JWST/MIRI. The inferred properties suggest rapid mass assembly and metal enrichment during the earliest phases of galaxy formation.

A neoadjuvant treatment regimen of anti-PD-L1 monotherapy followed by anti-PD-L1 plus chemotherapy was well tolerated and led to a major pathologic response rate of 70% in patients with resectable gastric or gastroesophageal junction adenocarcinoma.

Whereas bonds that strengthen under mechanical stress occur frequently in nature, all synthetic bonds weaken under force. Now, an artificial supramolecular catch bond has been shown to strengthen the particle–surface interface under increasing shear flow in a rolling adhesion assay, thereby mimicking biological adhesion processes.

X-ray flat-panel detector arrays with high spatial resolution and sensitivity can be created using a two-step manufacturing process that separates the fabrication of microcrystalline methylammonium lead triiodide absorber wafers from their integration on pixelated backplanes.

In this Consensus Statement, an international panel of experts present an overview of the latest developments in the field of cholangiocarcinoma. A set of consensus recommendations and research priorities is provided.

The study introduces NXT2 as a candidate gene for male infertility and shows that the encoded protein is involved in RNA nucleocytoplasmic transport in human testis by interacting with the RNA export factor NXF1 and proteins of the nuclear pore complex. NXT2 also interacts with the human testis-specific NXF1 paralogues NXF2 and NXF3. Mutations in NXT2 and NXF3 are linked to a disruption of nuclear export, leading to defective germ cell development and human male infertility.

Surface-deformation imaging, molecular-fracture sensors and modelling reveal that plant-pathogenic Phytophthora slice through the plant surface during host invasion. The underlying mechanism resembles cutting with a sharp knife and is termed naifu invasion.

The optical-gradient force between two nanophotonic waveguides can be tuned from attractive to repulsive by controlling the relative phase of the optical fields injected into the waveguides.