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Synaptic signatures and disease vulnerabilities of layer 5 pyramidal neurons

Authors use proximity proteomics to dissect the protein composition of the excitatory postsynaptic compartment of mouse L5 neurons in intact somatosensory circuits, reporting distinct synaptic signatures and differential disease vulnerabilities.

Gabriele Marcassa
Dan Dascenco
Joris de Wit
ResearchOpen Access02 Jan 2025
Nature Communications

Volume: 16, P: 1-16
Early alterations in the MCH system link aberrant neuronal activity and sleep disturbances in a mouse model of Alzheimer’s disease

Increased neuronal activity and reduced sleep quality emerge in the early stages of Alzheimer’s disease (AD). Calafate et al. show that the sleep–active hypothalamic MCH system is involved in neuronal homeostasis but fails in the early stages of AD.

Sara Calafate
Gökhan Özturan
Joris de Wit
ResearchOpen Access15 May 2023
Nature Neuroscience

Volume: 26, P: 1021-1031
Synapse type-specific proteomic dissection identifies IgSF8 as a hippocampal CA3 microcircuit organizer

Mossy fiber synapses are key in CA3 microcircuit function. Here, the authors profile the mossy fiber synapse proteome and cell-surface interactome. They uncover a diverse repertoire of cell-surface proteins and identify the receptor IgSF8 as a regulator of CA3 microcircuit connectivity and function.

Nuno Apóstolo
Samuel N. Smukowski
Joris de Wit
ResearchOpen Access14 Oct 2020
Nature Communications

Volume: 11, P: 1-21
γδ T cells are effectors of immunotherapy in cancers with HLA class I defects

γδ T cells contribute to the response to immune checkpoint blockade treatment in patients with HLA-class-I-negative DNA mismatch repair-deficient colon cancers. .

Natasja L. de Vries
Joris van de Haar
Emile E. Voest
ResearchOpen Access11 Jan 2023
Nature

Volume: 613, P: 743-750
High-throughput identification of human SNPs affecting regulatory element activity

Application of SuRE reporter technology to survey the effect of 5.9 million SNPs in the human genome on enhancer and promoter activity identifies over 30,000 SNPs that alter the activity of putative regulatory elements.

Joris van Arensbergen
Ludo Pagie
Bas van Steensel
Research28 Jun 2019
Nature Genetics

Volume: 51, P: 1160-1169
LRRTM2 controls presynapse nano-organization and AMPA receptor sub-positioning through Neurexin-binding interface

Synapse nanocolumns control neural transmission through precise alignment of neurotransmitter receptors and release sites. Here, the authors identify the Neurexin-LRRTM2 complex as a central organiser of excitatory synapse nanostructure and function.

Konstantina Liouta
Malgorzata Lubas
Ingrid Chamma
ResearchOpen Access11 Oct 2024
Nature Communications

Volume: 15, P: 1-18
Specification of synaptic connectivity by cell surface interactions

Cell surface molecule diversification has been proposed to confer specific surface identities on neuronal cell types, enabling the precise pattern of connectivity that is observed between CNS neurons. In this Review, de Wit and Ghosh explore the role of various protein superfamilies in the specification of such connectivity.

Joris de Wit
Anirvan Ghosh
Reviews10 Dec 2015
Nature Reviews Neuroscience

Volume: 17, P: 4
Tau association with synaptic vesicles causes presynaptic dysfunction

Mislocalisation of tau occurs in several neurodegenerative diseases and is thought to contribute to synaptic function. The authors show that presynaptically, tau binds to synaptic vesicles via the N-terminus which contributes to synaptic dysfunction.

Lujia Zhou
Joseph McInnes
Patrik Verstreken
ResearchOpen Access11 May 2017
Nature Communications

Volume: 8, P: 1-13
A20 critically controls microglia activation and inhibits inflammasome-dependent neuroinflammation

As resident macrophages of the brain, microglia are important for neuroinflammatory responses. This work shows that nuclear factor kappa B regulatory protein A20 is important for microglia activation and regulation during inflammation of the central nervous system.

Sofie Voet
Conor Mc Guire
Geert van Loo
ResearchOpen Access23 May 2018
Nature Communications

Volume: 9, P: 1-15
CD4⁺ T cells produce IFN-I to license cDC1s for induction of cytotoxic T-cell activity in human tumors

Xin Lei
Daniël C. de Groot
Yanling Xiao
ResearchOpen Access21 Feb 2024
Cellular & Molecular Immunology

Volume: 21, P: 374-392
Leucine-rich repeat-containing synaptic adhesion molecules as organizers of synaptic specificity and diversity

Anna Schroeder
Joris de Wit
ReviewsOpen Access09 Apr 2018
Experimental & Molecular Medicine

Volume: 50, P: 1-9
Ecto-Fc MS identifies ligand-receptor interactions through extracellular domain Fc fusion protein baits and shotgun proteomic analysis

In this protocol the authors describe a biochemical approach to identify ligand-receptor interactions in discovery mode with extracellular domain IgG fusion baits, tissue-extracted preys, and shotgun proteomic analysis.

Jeffrey N Savas
Joris De Wit
John R Yates III
Protocols07 Aug 2014
Nature Protocols

Volume: 9, P: 2061-2074
PCr/ATP ratios and mitochondrial function in the heart. A comparative study in humans

Vera H. W. de Wit-Verheggen
Vera B. Schrauwen-Hinderling
Tineke van de Weijer
ResearchOpen Access23 May 2023
Scientific Reports

Volume: 13, P: 1-10

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