Trithorax group (trxG) and Polycomb group (PcG) gene products are part of a chromatin remodelling system that activates or silences gene expression, respectively. This paper shows that show that Mll1 (mixed-lineage leukemia 1), a trxG member, is required for neurogenesis in the postnatal brain. They show that, in Mll1-deficient cells, expression of proneural and gliogenic regulatory genes are preserved, but Dlx2, a key downstream regulator of subventricular zone neurogenesis, is not expressed.
- Daniel A. Lim
- Yin-Cheng Huang
- Arturo Alvarez-Buylla
