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Interleukin-12 anchored drug conjugate (tolododekin alfa) in patients with advanced solid tumors: first-in-human Phase 1 trial

Tolododekin alfa is an anchored interleukin-12 conjugate enhancing tumour retention. Here, this group reports a Phase 1 trial evaluating the safety and biological activity of tolododekin alfa in patients with different advanced solid tumours.

Jong Chul Park
Brendan Curti
John M. Kirkwood
ResearchOpen Access29 Sept 2025
Nature Communications

Volume: 16, P: 1-12

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Interleukin-12 anchored drug conjugate (tolododekin alfa) in patients with advanced solid tumors: first-in-human Phase 1 trial

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