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Typical quantum error correcting codes assign fixed roles to the underlying physical qubits. Now the performance benefits of alternative, dynamic error correction schemes have been demonstrated on a superconducting quantum processor.

Artificial cilia array devices are developed for sound frequency decoding and executing tasks such as drug release.

Here the authors perform a trans expression quantitative trait locus meta-analysis study of over 3,700 people and link a USP18 variant to expression of 50 inflammation genes and lupus risk, highlighting how genetic regulation of immune responses drives autoimmune disease and informs new therapies.

Whether multimorbidity accelerates brain Aβ deposition in humans remains largely unknown. Here, the authors demonstrate that higher self-reported multimorbidity burden predicts increased brain Aβ accumulation rates in the ADNI cohort.

Microbubble interfaces exhibit unique chemical reactivity. Here, the authors visualize catalyst-free hydroxyl radical generation at nitrogen microbubbles, enabling pollutant degradation and sustainable nitrogen fixation under mild conditions.

A study of several longitudinal birth cohorts and cross-sectional cohorts finds only moderate overlap in genetic variants between autism that is diagnosed earlier and that diagnosed later, so they may represent aetiologically different conditions.

Federated learning (FL) algorithms have emerged as a promising solution to train models for healthcare imaging across institutions while preserving privacy. Here, the authors describe the Federated Tumor Segmentation (FeTS) challenge for the decentralised benchmarking of FL algorithms and evaluation of Healthcare AI algorithm generalizability in real-world cancer imaging datasets.

Genome-wide association meta-analyses of attention-deficit/hyperactivity disorder symptom measures and clinical diagnoses identify new risk loci, highlight putative effector genes and yield improved polygenic risk scores.

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

UTe₂ is a proposed intrinsic topological superconductor, but its quasiparticle surface band has not yet been visualized. Now this is achieved using quasiparticle interference imaging, revealing the symmetry of the superconducting order parameter.

Elevated temperatures inactivate a type I restriction endonuclease in P. aeruginosa for ~60 generations via proteolytic degradation triggered by DNA hypomodification, preventing self-targeting and enabling recovery of restriction activity.

In this Stage 2 Registered Report, Buchanan et al. show evidence confirming the phenomenon of semantic priming across speakers of 19 diverse languages.

Observed 730 Myr after the Big Bang, a little red dot is found to anchor an overdensity of eight galaxies and seems to be embedded in a massive host dark matter halo.

Multiancestry fine-mapping of brain protein quantitative trait loci coupled with Mendelian randomization analyses identifies protein–trait pairs consistent with causal effects across neurological and psychiatric conditions.

Friction consolidation transforms brittle Sm–Co powders into dense magnets via shear-driven redox reactions and localized heating, enabling phase-selective refinement and enhanced magnetization in a single-step, low-temperature process.

Resonant inelastic X-ray scattering can be used to measure the spin current carried by magnons in the presence of temperature gradients across a magnetic insulator.

This Review provides insights into nanosensor technologies for monitoring cellular biomarkers, proposing a spatial framework to clarify their distinct advantages, challenges and performance for high-resolution, dynamic profiling of cellular analytes.

In Alzheimer’s disease cohorts with whole genome sequencing and tau and amyloid-β, the authors show that sex, APOE-ε4 and TREM2 impact tau via both Aβ and tau pathways. APOE-ε4 homozygotes and TREM2 carriers showed greater neocortical tau pathology.

Here the authors report a low-cost method to fabricate flexible Ag2Se thermoelectric films with high performance and durability, enabling efficient energy harvesting and cooling in wearable and portable thermoelectric devices.

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Pharmacologic inhibition of dihydroorotate dehydrogenase (DHODH) shows limited efficacy in pancreatic ductal adenocarcinoma (PDAC) models. Here the authors find that targeting the anti-apoptotic protein BCL-XL synergizes with DHODH inhibition in promoting apoptosis in PDAC cells, patient-derived organoids, and PDAC mouse models.

Molecular conformation plays a vital role in biological processes. Here, the authors show that frequency-specific terahertz light enables precise and reversible control of molecular conformation, opening new avenues for biochemical modulation.

Genome-wide analyses identify 30 independent loci associated with obsessive–compulsive disorder, highlighting genetic overlap with other psychiatric disorders and implicating putative effector genes and cell types contributing to its etiology.

Inhibition of a cardiac stroma-enriched mechanosensor, SRC—in concert with suppression of the TGFβ pathway—potentiates the reversal of fibroblast activation and alleviates contractile dysfunction in fibrotic hearts.

A high-bandwidth neuromotor interface offers performant out-of-the-box generalization across people.

Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

In this work, authors perform a large-scale genetic screen to explore the previously unrecognized physical interaction between two transcription factors in Candida albicans. The roles of Stp2 and Dal81 are important in extracellular pH alkalization, fitness, and pathogenicity, key processes requiring coordinated gene regulatory networks governing amino acid metabolism.

A distinct population of CD4 T cells resides in specific regions of the steady-state brain, and these T cells are programmed in the periphery by the microbiome to coordinate adaptive behaviour.

This study shows that brain organoids from individuals with 22q11.2 deletion syndrome and schizophrenia have delayed neuron development, linked to altered gene regulation and microRNAs, offering insight into how this deletion raises psychiatric disease risk.

Magic state distillation is achieved with logical qubits on a neutral-atom quantum computer using a dynamically reconfigurable architecture for parallel quantum operations.

This study shows that many plants form a second, deeper root layer underground, enabling access to nutrient-rich deep soil. This previously unnoticed rooting pattern adds to the growing recognition that deep soil dynamics are overlooked.

Mouse models show that respiratory infections from viruses such as influenza and SARS-CoV-2 can trigger metastasis of dormant breast cancer cells in the lungs, a finding supported by epidemiological data from two large human cohorts.

Using RFdiffusion, a general method for targeting intrinsically disordered proteins and regions for protein design has been developed.

The potential of microsystem technologies to accelerate the development and clinical translation of immunotherapies is now being realized. This Review discusses recent advances in microsystem technologies, illustrating how their application can address key challenges related to the efficacy, toxicity, predictability and affordability of immunotherapeutics. Future directions and ongoing challenges facing the clinical translation of these technologies are discussed.  

Using well-calibrated statistical methods the authors jointly analyze Undiagnosed Diseases Network genomes, identifying known and novel disease genes. Software is publicly available to support future cross-cohort rare disease discovery efforts.

A study reports whole-genome sequences for 490,640 participants from the UK Biobank and combines these data with phenotypic data to provide new insights into the relationship between human variation and sequence variation.