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Showing 1–9 of 9 results
Advanced filters: Author: Juan J. Calix Clear advanced filters

  • Chiral agrochemicals are known for enhanced effects, but chiral supramolecular functional materials remain underexplored. Here, the authors engineered S and R chiral cyclodextrin-based carriers, where the R-enantiomer exhibits superior foliar adhesion and biofilm disruption—revealing their promise for agrochemical applications.

    • Min Liu
    • Kongjun Liu
    • Peiyi Wang
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-20

  • Infection is a major issue in chronic diabetic wounds. Here, the authors report on a hypoxia triggered drug delivery system to achieve higher drug levels with controlled release to treat wounds infected with multidrug-resistant pseudomonas aeruginosa and demonstrate antibacterial and anti-biofilm action

    • Juan-Juan Li
    • Yuqing Hu
    • Dong-Sheng Guo
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-12

  • Inherently chiral medium-ring derivatives have important applications in many research fields, but few enantioselective methods are available. Herein, the authors report the enantioselective N-heterocyclic carbenes-catalyzed formal (5 + 3) annulation of 1-(2-indolyl)naphthalen-2-ols with ynals for the synthesis of eight-membered lactones.

    • Shao-Qing Shi
    • Chen-Chang Cui
    • Bo Jiang
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-11

  • The natural product BE-43547A2 (BE) could potentially serve as a template of hypoxia target strategy for treating pancreatic cancer, but the unsatisfactory pharmacokinetics profile and severe toxicity impeded the application of BE or its derivatives. Here the authors report a supramolecular dual hypoxia-responsive BE-based complex for achieving efficient drug delivery within tumors.

    • Jian-Shuang Guo
    • Juan-Juan Li
    • Yue Chen
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-13

  • Encapsulating large and contorted nanographenes inside artificial receptors remain challenging. This work reports the synthesis, characterization and binding properties of a trigonal prismatic cage compound that can serve as a receptor for contorted nanographene derivatives.

    • Huang Wu
    • Yu Wang
    • J. Fraser Stoddart
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-13

  • A molecular tweezer has been shown to bind to the surface of a 14-3-3 protein through a particular lysine residue. This interaction — characterized in detail by protein crystallography and computational modelling — disrupts the protein's binding with partner proteins. These findings ascertain supramolecular chemistry as an enticing tool in chemical biology, here towards modulating protein functions.

    • David Bier
    • Rolf Rose
    • Christian Ottmann
    Research
    Nature Chemistry
    Volume: 5, P: 234-239

  • Marks and Calix et al. perform a case-control genomic epidemiology study comparing Staphylococcus aureus isolates from intravenous drug use-associated bloodstream infections with those from other bloodstream infections. The authors show there is clonal expansion of lineages in intravenous drug use-associated bloodstream infections suggesting person-to-person transmission of S. aureus.

    • Laura R. Marks
    • Juan J. Calix
    • Gautam Dantas
    ResearchOpen Access
    Communications Medicine
    Volume: 1, P: 1-10

  • Acinetobacter baumannii is generally considered an opportunistic pathogen. Here, Di Venanzio et al. develop a mouse model of catheter-associated urinary tract infection and show that a plasmid confers niche specificity to an A. baumannii urinary isolate by regulating the expression of chromosomal genes.

    • Gisela Di Venanzio
    • Ana L. Flores-Mireles
    • Mario F. Feldman
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-13