Nature Search

Targeting cancer cell dormancy

In this Viewpoint article, we asked six scientists working in the field of cancer dormancy to provide their opinions on the current state of the field and the challenges associated with translating dormancy research into the clinic.

Judith Agudo
Julio A. Aguirre-Ghiso
Christoph A. Klein
Reviews07 Dec 2023
Nature Reviews Cancer

Volume: 24, P: 97-104
Dietary cysteine enhances intestinal stemness via CD8⁺ T cell-derived IL-22

Dietary cysteine enhances intestinal stem cell-mediated intestinal repair following injury by promoting CD8 T cell-regenerative immune responses.

Fangtao Chi
Qiming Zhang
Ömer H. Yilmaz
Research01 Oct 2025
Nature

P: 1-10
SOX17 enables immune evasion of early colorectal adenomas and cancers

Transcriptomic and chromatin accessibility analyses of naive and transplanted colon cancer organoids in a mouse model reveal a key role for the transcription factor SOX17 in establishing a permissive immune environment for tumour cells.

Norihiro Goto
Peter M. K. Westcott
Ömer H. Yilmaz
Research28 Feb 2024
Nature

Volume: 627, P: 636-645
Stemness in solid malignancies: coping with immune attack

Immunotherapy shows promise in treating cancers by engineering T cells or using antibodies to activate them. However, cancer stem cells (CSCs) resist immunotherapies and drive cancer relapse. In this Review, Agudo and Miao highlight the mechanisms through which normal stem cells and CSCs in solid tumours achieve immune resistance, offering insights for the development of more effective cancer treatments.

Judith Agudo
Yuxuan Miao
Reviews25 Oct 2024
Nature Reviews Cancer

Volume: 25, P: 27-40
Mammary intraepithelial lymphocytes and intestinal inputs shape T cell dynamics in lactogenesis

Here Ramanan and colleagues provide an analysis of mammary T cells during late pregnancy and lactation. This revealed an increase in intraepithelial lymphocytes in the lactating mammary gland, which was driven by thymic and intestinal inputs and was sensitive to changes in the microbiota

Abigail Jaquish
Eleni Phung
Deepshika Ramanan
Research29 Jul 2025
Nature Immunology

Volume: 26, P: 1411-1422
Direct presentation of inflammation-associated self-antigens by thymic innate-like T cells induces elimination of autoreactive CD8⁺ thymocytes

The thymus harbors a complex constitutively active inflammatory network with innate-like T cells representing one of its central nodes. Here, the authors show that these cells can induce tolerance to inflammation-associated self-antigens, a class of molecules that otherwise largely mirrors the spatial and temporal distribution of pathogen-derived antigens.

Yuanyuan You
Josefine Dunst
Taras Kreslavsky
ResearchOpen Access11 Jul 2024
Nature Immunology

Volume: 25, P: 1367-1382
Molecular correlates of response to eribulin and pembrolizumab in hormone receptor-positive metastatic breast cancer

A randomized phase 2 clinical trial has recently shown no benefit of the combination eribulin and pembrolizumab over pembrolizumab alone in HR + metastatic breast cancer patients (NCT03051659). Here, the authors are reporting the final OS data and biomarker analyses on a subset of samples to analyze molecular correlates

Tanya E. Keenan
Jennifer L. Guerriero
Sara M. Tolaney
ResearchOpen Access21 Sept 2021
Nature Communications

Volume: 12, P: 1-13
PDL2⁺ CD11b⁺ dermal dendritic cells capture topical antigen through hair follicles to prime LAP⁺ Tregs

Antigen present and presented in the structures of the skin can result in immune responses that elicit tolerance, protective immunity or allergy, depending on the immunological context. Here the authors describe a key role for the hair follicle and CD11b⁺ dendritic cells in the priming of local antigenic tolerance.

Leticia Tordesillas
Daniel Lozano-Ojalvo
M. Cecilia Berin
ResearchOpen Access07 Dec 2018
Nature Communications

Volume: 9, P: 1-12
Hepatitis C virus genetics affects miR-122 requirements and response to miR-122 inhibitors

Replication of the hepatitis C virus (HCV) requires a host RNA molecule, miR-122, whose transient inhibition is being explored as an antiviral therapy. Here, the authors study the interaction between miR-122 and HCV, and identify mutations in HCV strains that affect susceptibility to miR-122 inhibition.

Benjamin Israelow
Gavriel Mullokandov
Matthew J. Evans
Research18 Nov 2014
Nature Communications

Volume: 5, P: 1-11
Genomic instability during reprogramming by nuclear transfer is DNA replication dependent

Chia et al. show that developmental arrest after human nuclear transfer is associated with genetic instability, including DNA damage, which occurs during DNA replication and is influenced by the developmental origin of the transferred nucleus.

Gloryn Chia
Judith Agudo
Dieter Egli
Research06 Mar 2017
Nature Cell Biology

Volume: 19, P: 282-291
The miR-126–VEGFR2 axis controls the innate response to pathogen-associated nucleic acids

Plasmacytoid dendritic cells produce copious amounts of type I interferon in response to viral infection. Brown and colleagues show that the homeostasis and function of these cells are regulated by the microRNA miR-126.

Judith Agudo
Albert Ruzo
Brian D Brown
Research24 Nov 2013
Nature Immunology

Volume: 15, P: 54-62
The influence of light and relative humidity on the formation of epsomite in cadmium yellow and French ultramarine modern oil paints

Jessie Harrison
Judith Lee
David J. Payne
ResearchOpen Access06 Sept 2021
Heritage Science

Volume: 9, P: 1-17
The first wave of the COVID-19 epidemic in Spain was associated with early introductions and fast spread of a dominating genetic variant

Analysis of 2,170 SARS-CoV-2 sequences from the first wave of the COVID-19 epidemic in Spain provides insights into transmission patterns and the effects of lockdown on the emergence of new variants.

Mariana G. López
Álvaro Chiner-Oms
Iñaki Comas
Research30 Sept 2021
Nature Genetics

Volume: 53, P: 1405-1414
GFP-specific CD8 T cells enable targeted cell depletion and visualization of T-cell interactions

T cells specific for GFP allow depletion of specific cell types in mice.

Judith Agudo
Albert Ruzo
Brian D Brown
Research02 Nov 2015
Nature Biotechnology

Volume: 33, P: 1287-1292
The immunity and redox clocks in mice, markers of lifespan

Judith Félix
Irene Martínez de Toda
Mónica De la Fuente
ResearchOpen Access19 Jan 2024
Scientific Reports

Volume: 14, P: 1-13
Mapping the effects of drugs on the immune system

The effects of drugs on the immune system is predicted by a data integration method.

Brian A Kidd
Aleksandra Wroblewska
Joel T Dudley
Research01 Jan 2016
Nature Biotechnology

Volume: 34, P: 47-54
Randomised, double-blind, placebo-controlled, parallel-group, multicentric, phase IIA clinical trial for evaluating the safety, tolerability, and therapeutic efficacy of daily oral administration of NFX88 to treat neuropathic pain in individuals with spinal cord injury

Pablo V. Escribá
Ángel M. Gil-Agudo
Antonio Oliviero
ResearchOpen Access19 Jun 2024
Spinal Cord

Volume: 62, P: 454-467
Genetic variation in NDFIP1 modifies the metabolic patterns in immune cells of multiple sclerosis patients

Pilar López-Cotarelo
Adela González-Jiménez
Elena Urcelay
ResearchOpen Access01 Nov 2021
Scientific Reports

Volume: 11, P: 1-9

Search

Targeting cancer cell dormancy

Dietary cysteine enhances intestinal stemness via CD8⁺ T cell-derived IL-22

SOX17 enables immune evasion of early colorectal adenomas and cancers

Stemness in solid malignancies: coping with immune attack

Mammary intraepithelial lymphocytes and intestinal inputs shape T cell dynamics in lactogenesis

Direct presentation of inflammation-associated self-antigens by thymic innate-like T cells induces elimination of autoreactive CD8⁺ thymocytes

Molecular correlates of response to eribulin and pembrolizumab in hormone receptor-positive metastatic breast cancer

PDL2⁺ CD11b⁺ dermal dendritic cells capture topical antigen through hair follicles to prime LAP⁺ Tregs

Hepatitis C virus genetics affects miR-122 requirements and response to miR-122 inhibitors

Genomic instability during reprogramming by nuclear transfer is DNA replication dependent

The miR-126–VEGFR2 axis controls the innate response to pathogen-associated nucleic acids

The influence of light and relative humidity on the formation of epsomite in cadmium yellow and French ultramarine modern oil paints

The first wave of the COVID-19 epidemic in Spain was associated with early introductions and fast spread of a dominating genetic variant

GFP-specific CD8 T cells enable targeted cell depletion and visualization of T-cell interactions

The immunity and redox clocks in mice, markers of lifespan

Mapping the effects of drugs on the immune system

Randomised, double-blind, placebo-controlled, parallel-group, multicentric, phase IIA clinical trial for evaluating the safety, tolerability, and therapeutic efficacy of daily oral administration of NFX88 to treat neuropathic pain in individuals with spinal cord injury

Genetic variation in NDFIP1 modifies the metabolic patterns in immune cells of multiple sclerosis patients

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