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Showing 1–4 of 4 results

Advanced filters: Author: Jueqi Chen Clear advanced filters

Type A cholesterol-dependent cytolysins translocate to the trans-Golgi network for NLRP3 inflammasome activation

Chen and colleagues show that type A cholesterol-dependent cytolysins, a group of bacteria pore-forming toxins, translocate to the trans-Golgi network to remodel it into a platform for NLRP3 activation.

Nanyang Xiao
Airi Kogishi
Jueqi Chen
Research05 Sept 2025
Nature Immunology

Volume: 26, P: 1673-1685
SARS-CoV-2 ORF3a drives dynamic dense body formation for optimal viral infectivity

Hartmann et al. discovered that SARS-CoV-2 constructs a group of dynamic membrane structures named the 3DB. 3DB regulates the processing of the viral spike protein to assemble a highly infectious virus, highlighting the potential of 3DB as a novel COVID-19 therapeutic target.

Stella Hartmann
Lisa Radochonski
Jueqi Chen
ResearchOpen Access12 May 2025
Nature Communications

Volume: 16, P: 1-22
PtdIns4P on dispersed trans-Golgi network mediates NLRP3 inflammasome activation

Recruitment of NLRP3 to the dispersed trans-Golgi network via binding to PtdIns4P is required for activation of the NLRP3 inflammasome by diverse stimuli.

Jueqi Chen
Zhijian J. Chen
Research28 Nov 2018
Nature

Volume: 564, P: 71-76
The correlation between different metabolic scores and the risk of cardiometabolic comorbidities in hypertensive patients

Guliman Muheiyati
Jueqi Wang
Ning Tao
ResearchOpen Access30 Sept 2025
Scientific Reports

Volume: 15, P: 1-10