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IL-17A-producing NKp44(−) group 3 innate lymphoid cells accumulate in Familial Adenomatous Polyposis duodenal tissue

Familial adenomatous polyposis (FAP) is an inherited gastrointestinal syndrome associated with duodenal adenoma formation. Here the authors show that IL17A-producing NKp44- group 3 innate lymphoid cells accumulate in FAP duodenal tissue and are associated with duodenal adenoma formation in patients with FAP.

Kim M. Kaiser
Jan Raabe
Jacob Nattermann
ResearchOpen Access25 Apr 2025
Nature Communications

Volume: 16, P: 1-19
Evolution of retinal degeneration and prediction of disease activity in relapsing and progressive multiple sclerosis

The prognostic value of OCT in progressive vs relapsing multiple sclerosis (MS) is not clear. Analyzing 2651 OCTs of 407 MS patients, OCT predicted activity in all MS subtypes cross sectionally but longitudinal changes were not predictive in a multicenter setting.

Julia Krämer
Carolin Balloff
Philipp Albrecht
ResearchOpen Access19 Jun 2024
Nature Communications

Volume: 15, P: 1-16
Single-cell analysis identifies the CNP/GC-B/cGMP axis as marker and regulator of modulated VSMCs in atherosclerosis

The second messenger 3’,5’-cyclic guanosine monophosphate (cGMP) is important for the maintenance of cardiovascular homeostasis. Here, correlative single-cell profiling of cGMP dynamics and vascular cell phenotype reveals a druggable atheroprotective mechanism and suggests parallels between remodeling processes in bone and atherosclerotic arteries.

Moritz Lehners
Hannes Schmidt
Robert Feil
ResearchOpen Access15 Jan 2025
Nature Communications

Volume: 16, P: 1-21
Swarm Learning for decentralized and confidential clinical machine learning

Swarm Learning is a decentralized machine learning approach that outperforms classifiers developed at individual sites for COVID-19 and other diseases while preserving confidentiality and privacy.

Stefanie Warnat-Herresthal
Hartmut Schultze
Joachim L. Schultze
ResearchOpen Access26 May 2021
Nature

Volume: 594, P: 265-270
Striated muscle-specific base editing enables correction of mutations causing dilated cardiomyopathy

Dilated cardiomyopathy is the second most common cause for heart failure. Here the authors combine CRISPR base editors with the muscle-targeting viral vector AAVMYO to repair patient mutations in the cardiac splice factor Rbm20 in two mouse models.

Markus Grosch
Laura Schraft
Lars M. Steinmetz
ResearchOpen Access22 Jun 2023
Nature Communications

Volume: 14, P: 1-15
Mybpc3 gene therapy for neonatal cardiomyopathy enables long-term disease prevention in mice

Hereditary hypertrophic cardiomyopathy (HCM) is caused by mutations in cardiomyocyte genes, such as MYBPC3. Here, the authors use virus-mediated gene therapy to correct Mycbpc3mutations in 1-day-old mice and, by administering just a single dose, prevent development of HCM over a period of 34 weeks.

Giulia Mearini
Doreen Stimpel
Lucie Carrier
Research02 Dec 2014
Nature Communications

Volume: 5, P: 1-10
Translational fidelity and growth of Arabidopsis require stress-sensitive diphthamide biosynthesis

Diphthamide is a post-translationally modified histidine residue present in animal and yeast TRANSLATION ELONGATION FACTOR2. Here the authors show that diphthamide modification of eEF2 is conserved in Arabidopsis thaliana and contributes to translational fidelity and growth via cell proliferation.

Hongliang Zhang
Julia Quintana
Ute Krämer
ResearchOpen Access11 Jul 2022
Nature Communications

Volume: 13, P: 1-14
A CYBDOM protein impacts iron homeostasis and primary root growth under phosphate deficiency in Arabidopsis

Iron deposition in cell walls inhibits Arabidopsis root growth under phosphate deficiency. A protein with iron reductase activity belonging to an uncharacterized CYBDOM family was identified which modulates this process and affects iron homeostasis.

Joaquín Clúa
Jonatan Montpetit
Yves Poirier
ResearchOpen Access11 Jan 2024
Nature Communications

Volume: 15, P: 1-20
Toxicity modelling of Plk1-targeted therapies in genetically engineered mice and cultured primary mammalian cells

Polo-like kinase 1 is a key regulator of mitosis and is a candidate for drug development to treat cancer. Here, reduced expression of polo-like kinase 1 in adult mice has a minor impact on animal physiology, suggesting that polo-like kinase 1 inhibitors may be useful in the killing of tumour cells while sparing normal cells.

Monika Raab
Sven Kappel
Klaus Strebhardt
ResearchOpen Access19 Jul 2011
Nature Communications

Volume: 2, P: 1-11
Bruton tyrosine kinase inhibitors for multiple sclerosis

Bruton tyrosine kinase inhibitors are an emerging treatment for multiple sclerosis. Krämer et al. consider the evidence that central nervous system-penetrant Bruton tyrosine kinase inhibitors might target both peripheral immune cells and compartmentalized inflammation and discuss promising preliminary results of clinical trials of these agents in multiple sclerosis.

Julia Krämer
Amit Bar-Or
Heinz Wiendl
Reviews13 Apr 2023
Nature Reviews Neurology

Volume: 19, P: 289-304
Hepatic Rab24 controls blood glucose homeostasis via improving mitochondrial plasticity

Non-alcoholic steatohepatitis (NASH) is characterized by lipid accumulation within hepatocytes and fibrosis. Seitz et al. show that the GTPase protein Rab24 is increased in the livers of people who are obese or have NASH.

Susanne Seitz
Yun Kwon
Anja Zeigerer
Research14 Oct 2019
Nature Metabolism

Volume: 1, P: 1009-1026
Severe SMA mice show organ impairment that cannot be rescued by therapy with the HDACi JNJ-26481585

Julia Schreml
Markus Riessland
Brunhilde Wirth
Research17 Oct 2012
European Journal of Human Genetics

Volume: 21, P: 643-652
The power of imaging to understand extracellular vesicle biology in vivo

This Review describes the state of the art in imaging extracellular vesicles in animals to study their release, biodistribution and uptake, and covers labeling strategies, microscopy methods and discoveries made in model organisms.

Frederik J. Verweij
Leonora Balaj
Guillaume van Niel
Reviews26 Aug 2021
Nature Methods

Volume: 18, P: 1013-1026
Molecular composition of skeletal muscle in infants and adults: a comparative proteomic and transcriptomic study

Alexander Schaiter
Andreas Hentschel
Anne Schänzer
ResearchOpen Access03 Oct 2024
Scientific Reports

Volume: 14, P: 1-18
PSYSCAN multi-centre study: baseline characteristics and clinical outcomes of the clinical high risk for psychosis sample

Stefania Tognin
Sandra Vieira
Philip McGuire
ResearchOpen Access17 Apr 2025
Schizophrenia

Volume: 11, P: 1-9
Gene regulation for inflammation and inflammation resolution differs between umbilical arterial and venous endothelial cells

Julia Caroline Michaeli
Sebastian Albers
Benito A. Yard
ResearchOpen Access27 Sept 2023
Scientific Reports

Volume: 13, P: 1-11
Co-activation of Sonic hedgehog and Wnt signaling in murine retinal precursor cells drives ocular lesions with features of intraocular medulloepithelioma

Matthias Dottermusch
Piotr Sumisławski
Julia E. Neumann
ResearchOpen Access16 Nov 2021
Oncogenesis

Volume: 10, P: 1-13
Multivariable prediction of functional outcome after first-episode psychosis: a crossover validation approach in EUFEST and PSYSCAN

Margot I. E. Slot
Maria F. Urquijo Castro
René S. Kahn
ResearchOpen Access07 Oct 2024
Schizophrenia

Volume: 10, P: 1-11
Antimicrobial peptide cWFW kills by combining lipid phase separation with autolysis

Kathi Scheinpflug
Michaela Wenzel
Henrik Strahl
ResearchOpen Access09 Mar 2017
Scientific Reports

Volume: 7, P: 1-15

Search

IL-17A-producing NKp44(−) group 3 innate lymphoid cells accumulate in Familial Adenomatous Polyposis duodenal tissue

Evolution of retinal degeneration and prediction of disease activity in relapsing and progressive multiple sclerosis

Single-cell analysis identifies the CNP/GC-B/cGMP axis as marker and regulator of modulated VSMCs in atherosclerosis

Swarm Learning for decentralized and confidential clinical machine learning

Striated muscle-specific base editing enables correction of mutations causing dilated cardiomyopathy

Mybpc3 gene therapy for neonatal cardiomyopathy enables long-term disease prevention in mice

Translational fidelity and growth of Arabidopsis require stress-sensitive diphthamide biosynthesis

A CYBDOM protein impacts iron homeostasis and primary root growth under phosphate deficiency in Arabidopsis

Toxicity modelling of Plk1-targeted therapies in genetically engineered mice and cultured primary mammalian cells

Bruton tyrosine kinase inhibitors for multiple sclerosis

Hepatic Rab24 controls blood glucose homeostasis via improving mitochondrial plasticity

Severe SMA mice show organ impairment that cannot be rescued by therapy with the HDACi JNJ-26481585

The power of imaging to understand extracellular vesicle biology in vivo

Molecular composition of skeletal muscle in infants and adults: a comparative proteomic and transcriptomic study

PSYSCAN multi-centre study: baseline characteristics and clinical outcomes of the clinical high risk for psychosis sample

Gene regulation for inflammation and inflammation resolution differs between umbilical arterial and venous endothelial cells

Co-activation of Sonic hedgehog and Wnt signaling in murine retinal precursor cells drives ocular lesions with features of intraocular medulloepithelioma

Multivariable prediction of functional outcome after first-episode psychosis: a crossover validation approach in EUFEST and PSYSCAN

Antimicrobial peptide cWFW kills by combining lipid phase separation with autolysis

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