Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–7 of 7 results
Advanced filters: Author: Julie G. Hussin Clear advanced filters

  • The question of whether recombination rate increases with maternal age is controversial, with conflicting prior evidence. Here, Martin et al.analyse nine cohorts in the largest SNP-based analysis of this question and find a small positive increase with maternal age in the number of crossovers.

    • Hilary C. Martin
    • Ryan Christ
    • Peter Donnelly
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-10

  • The identification of T cell epitopes is a critical step in understanding the immune response to infection and in designing vaccine based approaches. Here the authors introduce a frame work of antigen discovery called MHCvalidator and Epitrack to identify new antigenic features for T-cell COVID-19 vaccines and characterise a novel non-canonical epitope from a truncated Spike variant and mutation of an immunodominant epitope in the BNT162b4 vaccine.

    • Kevin A. Kovalchik
    • David J. Hamelin
    • Etienne Caron
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-22

  • PRDM9 is a DNA-binding protein that controls the position of double-strand breaks in meiosis, and the gene that encodes it is responsible for hybrid infertility between closely related mouse species; this hybrid infertility is eliminated by introducing the zinc-finger domain sequence from the human version of the PRDM9 gene, a change which alters both the position of double-strand breaks and the symmetry of PRDM9 binding and suggests that PRDM9 may have a more general but transient role in the early stages of speciation.

    • Benjamin Davies
    • Edouard Hatton
    • Peter Donnelly
    Research
    Nature
    Volume: 530, P: 171-176

  • Philip Awadalla and colleagues report an analysis of the relationship between recombination and deleterious variation using high-coverage sequence data from over 1,400 individuals. They find that the recombination rate modulates the distribution of putatively deleterious variants across the human genome.

    • Julie G Hussin
    • Alan Hodgkinson
    • Philip Awadalla
    Research
    Nature Genetics
    Volume: 47, P: 400-404