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Viral ribonucleoprotein–viral protein networks form pre-replication centres that nucleate viral factories and drive respiratory syncytial virus replication.

Floquet engineering is often limited by weak light–matter coupling and heating. Now it is shown that exciton-driven fields in monolayer semiconductors produce stronger, longer-lived Floquet effects and reveal hybridization linked to excitonic phases.

Here the authors report single-cell and spatial transcriptomics of young and aged male fibrotic mouse lungs. Age-related alterations in capillary sub-populations are associated with a proangiogenic phenotype linked to regeneration of the alveolar niche.

Antimicrobial resistance poses a significant global health threat, necessitating swift and precise diagnostic solutions. Here, the authors introduce a culture-free diagnostic platform integrating microfluidic cell enrichment, single-cell Raman spectroscopy, and deep learning, that identifies bacterial and fungal infections directly from clinical samples within 20 minutes.

The mechanical properties of nanoporous gold are tied to their topology and surface morphology. Here, a correlative and scale-bridging approach, combining non-destructive 3D tomography, mechanical testing and experimentally-informed modelling, reveals the origins of the size dependent deformation mechanisms.

Mass cytometry can be used to scale up multiplexed serology testing, as shown for the simultaneous detection of antibody levels against multiple SARS-CoV-2 proteins in hundreds of serum samples.

Addition of an inexpensive, biocompatible polymer reduces spontaneous fusions of organoids in culture.

Maintaining neural progenitor cell stemness has proven challenging in vitro, due to their propensity to form cell-dense neurospheres. Here, the authors developed a 3D hydrogel system that supports neural progenitor cell stemness maintenance and differentiation by tuning matrix mechanics and cell-binding cues, enabling long-term expansion and neuron formation without needing dense cell clusters.

Multiplexed editing using Cas12a transgenic mice facilitates the study of disease models with complex genotypes.

The authors report thermally activated delayed fluorescence in rigid planar donor-acceptor molecules achieving decoupling of ground and excited states through a bonding/antibonding connectivity between donor and acceptor without alarge dihedral twist angle between them.

A mechanical injector that targets tissue by sensing the loss-of-resistance on encountering softer tissue or a cavity can reliably and precisely deliver liquids to the suprachoroidal space, and to other injection-accessible target sites in the body.

The authors use femtosecond K-edge X-ray absorption spectroscopy to follow nuclear motion in a manganese-based tri-nuclear single-molecule magnet, and resolve changes in bond lengths on the order of hundreds of ångströms and on sub-picosecond timescales.

In this study, the authors estimate excess mortality at the regional level for five European countries (England, Greece, Italy, Spain, and Switzerland) in 2020. They identify the regions and time periods with highest excess mortality and show how these patterns evolved through different pandemic waves.

Downregulation of the transcription factor KLF4 in keratinocyte precursors improves the proliferation and maintenance of immature keratinocytes in vitro and the generation of epidermis in vivo.

Swarm Learning is a decentralized machine learning approach that outperforms classifiers developed at individual sites for COVID-19 and other diseases while preserving confidentiality and privacy.

Patient-derived intestinal organoids and tumouroids supplemented with immune cells can be used to predict and study the on-target off-tumour toxicities of T-cell-engaging bispecific antibodies and to capture inter-patient variabilities in the responses to the antibodies.

Controlling single-molecule magnets (SMMs) with ultrashort laser pulses could be key to future data storage devices, however, the photophysics of SMMs is complex. Now, using a monomer model system, it has been shown that optical excitation of Mn(iii)-SMMs leads to a modulation of the Jahn–Teller distortion, which is important for its magnetic anisotropy.

A Zika virus (ZIKV) vaccine should provide long-lasting immunity, which may be achieved with a live-attenuated vaccine. Here, Kwek et al. select an interferon-restricted, attenuated ZIKV variant and evaluate replication and immunogenicity in mouse and mosquito models.

Boon et al. show that thalidomide appears to be efficacious in the management of chronic pain, bleeding and ulceration in 18 patients with severely symptomatic arteriovenous malformations refractory to conventional therapies.

The crystal structure of V1/V2, the only unresolved portion of the HIV-1 gp120 envelope glycoprotein, is reported in complex with human antibody PG9 and reveals a paradigm of antibody recognition with implications for vaccine development.

Guillaume Dion and co-authors present the gait pattern recognition micro-electromechanical sensor. The effective coupling between sensing and computing capabilities allows in-sensor processing for robust, secure and low-power data analysis.

A general-purpose framework and continuous miniaturization have been key to the success of CMOS technology. However, the recent explosion in compute requirements across a growing variety of architectures and applications is happening at a time when CMOS technology faces unprecedented scaling and cost challenges. This requires reimagining of the existing paradigm.

Richard Hopper and colleagues design a multi-channel odor delivery system. Their device allows high precision olfactory experiences to be created with a compact desktop unit.

The process of thermally activated delayed fluorescence (TADF) converts non-radiative triplet states into emissive singlet states. Herein we outline the fundamentals of TADF, some of the recent progress in understanding the key material properties responsible for promoting TADF and finally discuss some remaining challenges for the  potential applications of this phenomenon.