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Showing 1–11 of 11 results
Advanced filters: Author: Julien Mena Clear advanced filters

  • The molecular mechanisms underlying drug resistance in relapsed or refractory (rr) acute myeloid leukemia (AML) remain to be explored. Here, the use of bulk and single cell multi-omics and ex vivo drug profiling for 21 rrAML patients reveals mechanisms of resistance to the Bcl-2 inhibitor venetoclax and treatment vulnerabilities.

    • Rebekka Wegmann
    • Ximena Bonilla
    • Alexandre P. A. Theocharides
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-18

  • In the Tumor Profiler proof-of-concept observational study, a multiomics approach for profiling tumors from patients with melanoma was feasible, returning data within 4 weeks and informing treatment recommendations in 75% of cases.

    • Nicola Miglino
    • Nora C. Toussaint
    • Andreas Wicki
    ResearchOpen Access
    Nature Medicine
    Volume: 31, P: 2430-2441

  • HistoPlexer, a deep learning model, generates multiplexed protein expression maps from H&E images, capturing tumour–immune cell interactions. It outperforms baselines, enhances immune subtyping and survival prediction and offers a cost-effective tool for precision oncology.

    • Sonali Andani
    • Boqi Chen
    • Gunnar Rätsch
    ResearchOpen Access
    Nature Machine Intelligence
    Volume: 7, P: 1292-1307

  • A single-cell ex vivo screening of repurposable drugs in glioblastoma and machine learning of drug–target networks show that anti-tumor neuroactive drugs converge on the AP-1/BTG pathway, based on which prediction models and experimental in vivo and in silico validation identify the anti-depressant vortioxetine as a potential therapeutic agent.

    • Sohyon Lee
    • Tobias Weiss
    • Berend Snijder
    ResearchOpen Access
    Nature Medicine
    Volume: 30, P: 3196-3208

  • The origins of the enigmatic extinct Falkland Islands wolf have remained a mystery since first records in the seventeenth century. Ancient DNA data and evidence from submarine terraces reveal that the species colonized the islands during the Last Glacial Maximum via a shallow, potentially frozen, marine strait.

    • Jeremy J. Austin
    • Julien Soubrier
    • Alan Cooper
    Research
    Nature Communications
    Volume: 4, P: 1-7

  • Myelofibrosis is a form of myeloproliferative neoplasm with few treatment options available. Here, the authors profiled drug responses and proteomics ex vivo and identify molecularly-guided treatment strategies, including HDAC and BET inhibitors for CALR mutant myelofibrosis patients.

    • Mattheus H. E. Wildschut
    • Julien Mena
    • Berend Snijder
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-19

  • Long-read single-cell RNA sequencing is capable of detecting isoform-level gene expression and genomic alterations such as mutations and gene fusions, thereby providing cell-specific genotype-phenotype information. Here, the authors use long-read scRNA-seq on metastatic ovarian cancer samples and detect cell-type specific isoforms and gene fusions that may otherwise be misclassified in short-read data.

    • Arthur Dondi
    • Ulrike Lischetti
    • Niko Beerenwinkel
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-19

  • The authors present a robust diagnostic algorithm based on digital pathology and image analysis that quantifies intratumoral and stromal CD8+ T-cell densities in the tumor center and invasive margin compartment in metastatic melanoma. Spatial CD8+ T-cell densities are translated into the clinically relevant immune diagnostic categories “inflamed”, “excluded”, and “desert”. Their approach also allows efficient immune phenotyping of metastatic lesions, on biopsy material or even in the absence of material from the invasive margin.

    • Bettina Sobottka
    • Marta Nowak
    • Viktor Hendrik Koelzer
    ResearchOpen Access
    Laboratory Investigation
    Volume: 101, P: 1561-1570