Receptor-interacting protein kinase 1 (RIPK1) plays key roles in regulating multiple signalling pathways. Here, using solid state NMR, the authors report the amyloid structure of mouse RIPK1, formed by an 82-residue sequence centred at RHIM: it adopts an “N”-shaped folding of the protein subunit in the fibril.
- Jing Liu
- Xia-lian Wu
- Jun-xia Lu