Nature Search

Navigating condensate micropolarity to enhance small-molecule drug targeting

Using computational and experimental methods, Ouyang and Chen et al. reveal a drug design principle that the hydrophobic properties of small-molecule drugs significantly influence their ability to engage with and effectively target phase-separated proteins.

Jian Ouyang
Junlin Chen
Tingting Li
Research09 Sept 2025
Nature Chemical Biology

P: 1-11
Mitigating cardiac allograft vasculopathy in a murine model via CD40-TRAF6 blockade and cyclosporin A synergy

Yajun Huang
Junlin Lai
Guohua Wang
ResearchOpen Access01 Jul 2025
Scientific Reports

Volume: 15, P: 1-13
Development and validation of deep learning algorithms for scoliosis screening using back images

Junlin Yang et al. develop deep learning algorithms that diagnose adolescent idiopathic scoliosis with its accuracy superior to human specialists. This method reduces patients’ exposure to radiation and unnecessary referrals when used for routine scoliosis screening and periodic follow-ups.

Junlin Yang
Kai Zhang
Haotian Lin
ResearchOpen Access25 Oct 2019
Communications Biology

Volume: 2, P: 1-8
Lactate-to-albumin ratio as an independent predictor of 28-day ICU mortality in patients with hypertension: a retrospective cohort study

Kaifeng Han
Guode Li
Zhichao Zhao
ResearchOpen Access26 Sept 2025
Scientific Reports

Volume: 15, P: 1-12
Treatment response-adapted risk index model for survival prediction and adjuvant chemotherapy selection in nonmetastatic nasopharyngeal carcinoma

Yang Liu
Wenbin Yan
Junlin Yi
ResearchOpen Access01 Sept 2025
npj Digital Medicine

Volume: 8, P: 1-13
M-Phase Phosphoprotein 9 regulates ciliogenesis by modulating CP110-CEP97 complex localization at the mother centriole

Ciliogenesis is negatively regulated by the CP110-CEP97 complex, although the mechanism controlling mother centriole localization is poorly understood. Here, Huang et al. show that KIF24 recruits MMP9 to the mother centriole, where it regulates ciliogenesis by controlling CP110-CEP97 recruitment.

Ning Huang
Donghui Zhang
Jianguo Chen
ResearchOpen Access30 Oct 2018
Nature Communications

Volume: 9, P: 1-15
Hierarchical assembly of centriole subdistal appendages via centrosome binding proteins CCDC120 and CCDC68

Centriole subdistal appendages (SDAs) anchor microtubules in interphase cells, but their composition and assembly mechanisms are unclear. Here the authors show that two new SDA components, CCDC120 and CCDC68, are required for hierarchical SDA assembly and centrosome microtubule anchoring.

Ning Huang
Yuqing Xia
Jianguo Chen
ResearchOpen Access19 Apr 2017
Nature Communications

Volume: 8, P: 1-14
Enterprise digital transformation and inefficient investment: from the perspective of diversified operations and environmental uncertainty

Ziqian Peng
Haiyang Zhang
Yanbai Chen
ResearchOpen Access02 Aug 2025
Humanities and Social Sciences Communications

Volume: 12, P: 1-16
Cell surface patching via CXCR4-targeted nanothreads for cancer metastasis inhibition

CXCR4-targeted therapies have been proposed for the treatment of cancer metastasis. Here the authors propose a CXCR4-targeted strategy based on interactable polymer nanothreads, showing inhibition of metastasis in preclinical cancer models.

Minglu Zhou
Chendong Liu
Lian Li
ResearchOpen Access29 Mar 2024
Nature Communications

Volume: 15, P: 1-21
Mitochondrial dynamics quantitatively revealed by STED nanoscopy with an enhanced squaraine variant probe

Live cell imaging of mitochondrial cristae is challenged by the unsuitability of current fluorescent probes and high phototoxicity. Here the authors develop a squarine variant probe (MitoESq-635) that is capable of longitudinal imaging of cristae with STED with minimal phototoxicity.

Xusan Yang
Zhigang Yang
Peng Xi
ResearchOpen Access24 Jul 2020
Nature Communications

Volume: 11, P: 1-9
Evidence for weak seismic attenuation in Mars’ deep mantle

The deep mantle of Mars displays markedly lower seismic attenuation than that of Earth, which could reflect differences in water content, grain size, oxygen fugacity, or temperature, according to an analysis of seismic data from marsquakes and meteorite impacts

Jiaqi Li
Junlin Hua
Tong Zhou
ResearchOpen Access13 Aug 2025
Communications Earth & Environment

Volume: 6, P: 1-11
Light-induced activation of boron doping in hydrogenated amorphous silicon for over 25% efficiency silicon solar cells

Low effective doping of boron limits the performance of solar cells based on hydrogenated amorphous silicon. Liu et al. show that light induces the diffusion of hydrogen atoms, which activates boron doping, enabling a power conversion efficiency of over 25%.

Wenzhu Liu
Jianhua Shi
Zhengxin Liu
ResearchOpen Access12 May 2022
Nature Energy

Volume: 7, P: 427-437
An epimer of threose nucleic acid enhances oligonucleotide exonuclease resistance through end capping

End capping of oligonucleotides is crucial for enhancing their stability and therapeutic efficacy by resisting 3’ exonuclease degradation, yet the underlying mechanisms remain elusive. Here, the authors design an epimer of threose nucleic acid by replacing deoxyribose with an α-D-erythrofuranosyl moiety, demonstrating its superior stability and resistance by affecting the binding positions of terminal nucleotides in the phosphodiesterase active site.

Junlin Wen
Chunlei Zhang
Hui Mei
ResearchOpen Access13 May 2025
Communications Chemistry

Volume: 8, P: 1-12
Dual stimuli-responsive rotaxane-branched dendrimers with reversible dimension modulation

Mechanically interlocked molecules are extensively applied as artificial molecular machines but rotaxane-branched dendrimers are rarely explored because of synthetic challenges. Here the authors present the construction of dual stimuli-responsive rotaxane-branched dendrimer which can be stimulated by DMSO or acetate ions.

Xu-Qing Wang
Wei Wang
Hai-Bo Yang
ResearchOpen Access09 Aug 2018
Nature Communications

Volume: 9, P: 1-11
A distinct entorhinal cortex to hippocampal CA1 direct circuit for olfactory associative learning

Entorhinal cortex transfers multimodal information to hippocampus CA1 neurons via indirect and direct pathways. The authors show that excitatory projections from lateral entorhinal cortex selectively target a subpopulation of morphologically complex, calbindin-expressing pyramidal cells in CA1, forming a distinct direct circuit that is required for olfactory associative learning.

Yiding Li
Jiamin Xu
Xiaohui Zhang
Research06 Mar 2017
Nature Neuroscience

Volume: 20, P: 559-570
UBE2S interacting with TRIM21 mediates the K11-linked ubiquitination of LPP to promote the lymphatic metastasis of bladder cancer

Kanghua Xiao
Shengmeng Peng
Tianxin Lin
ResearchOpen Access08 Jul 2023
Cell Death & Disease

Volume: 14, P: 1-13
Prioritizing antiviral drugs against SARS-CoV-2 by integrating viral complete genome sequences and drug chemical structures

Lihong Peng
Ling Shen
Liqian Zhou
ResearchOpen Access18 Mar 2021
Scientific Reports

Volume: 11, P: 1-11
Observation of five types of leaders contained in a negative triggered lightning

Jianguo Wang
Rui Su
Yijun Huang
ResearchOpen Access15 Apr 2022
Scientific Reports

Volume: 12, P: 1-12
Towards next-generation diagnostic pathology: AI-empowered label-free multiphoton microscopy

AI-empowered multiphoton microscopy enhances diagnostic accuracy and efficiency for various human diseases, evolving towards next-generation diagnostic pathology with an endogenous, multi-dimensional, and intelligent approach.

Shu Wang
Junlin Pan
Jianxin Chen
ReviewsOpen Access14 Sept 2024
Light: Science & Applications

Volume: 13, P: 1-25
Fast Super-Resolution Imaging with Ultra-High Labeling Density Achieved by Joint Tagging Super-Resolution Optical Fluctuation Imaging

Zhiping Zeng
Xuanze Chen
Peng Xi
ResearchOpen Access10 Feb 2015
Scientific Reports

Volume: 5, P: 1-7
Manipulating the air-filled zebrafish swim bladder as a neutrophilic inflammation model for acute lung injury

Yuefei Zhang
Hongcui Liu
Yuehai Ke
ResearchOpen Access10 Nov 2016
Cell Death & Disease

Volume: 7, P: e2470

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