Nature Search

Synapses take the rap

Stanley C. Froehner
Justin R. Fallon
News & Views21 Sept 1995
Nature

Volume: 377, P: 195-196
Acetylcholine receptor-aggregating factor is similar to molecules concentrated at neuromuscular junctions

Justin R. Fallon
Ralph M. Nitkin
U. J. McMahan
Research13 Jun 1985
Nature

Volume: 315, P: 571-574
Publisher Correction: TDP-43 gains function due to perturbed autoregulation in a Tardbp knock-in mouse model of ALS-FTD

Matthew A. White
Eosu Kim
Jemeen Sreedharan
Amendments and Corrections05 Jun 2018
Nature Neuroscience

Volume: 21, P: 1138
Aggregates of acetylcholinesterase induced by acetylcholine receptor-aggregating factor

Bruce G. Wallace
Ralph M. Nitkin
U. J. McMahan
Research13 Jun 1985
Nature

Volume: 315, P: 574-577
Internalization of ionotropic glutamate receptors in response to mGluR activation

Eric M. Snyder
Benjamin D. Philpot
Mark F. Bear
Research22 Oct 2001
Nature Neuroscience

Volume: 4, P: 1079-1085
A massively parallel reporter assay library to screen short synthetic promoters in mammalian cells

Context-dependent, responsive synthetic promoters are crucial for a wide range of applications, yet currently available options are limited. Here, authors develop a library of thousands of candidate promoters based on binding motifs of hundreds transcription factors for use in mammalian cells.

Adam M. Zahm
William S. Owens
Justin G. English
ResearchOpen Access28 Nov 2024
Nature Communications

Volume: 15, P: 1-14
Evidence against tetrapod-wide digit identities and for a limited frame shift in bird wings

The homology of digits across amniotes is debated. Here, the authors compare the developmental transcriptomes of digits across five divergent amniotes and show high evolutionary dynamism in expression profiles, with conservation of a distinct developmental identity only in the anterior-most digit.

Thomas A. Stewart
Cong Liang
Günter P. Wagner
ResearchOpen Access19 Jul 2019
Nature Communications

Volume: 10, P: 1-13
Synapses go nucle(ol)ar

Jordan and colleagues report that activity causes the shuttling of a synaptic protein AIDA-1d from dendritic spines to the nucleus. This work sheds light on how nuclear protein synthesis is regulated in response to synaptic activity.

Joel D Richter
Justin R Fallon
News & Views01 Apr 2007
Nature Neuroscience

Volume: 10, P: 399-400
TDP-43 gains function due to perturbed autoregulation in a Tardbp knock-in mouse model of ALS-FTD

TDP-43 gains function due to perturbed autoregulation in a Tardbp knock-in mouse model of ALS-FTD, leading to aberrant Mapt splicing and a paucity of parvalbumin interneurons. Phenotypic heterogeneity is exploited to yield modifiers of disease.

Matthew A. White
Eosu Kim
Jemeen Sreedharan
Research19 Mar 2018
Nature Neuroscience

Volume: 21, P: 552-563
Dendritic mRNA translation: deciphering the uncoded

The interaction of two untranslated sequences in the mRNA for calcium/calmodulin-dependent protein kinase II could regulate its activity-dependent transport into dendrites.

David G. Wells
Justin R. Fallon
News & Views01 Nov 2000
Nature Neuroscience

Volume: 3, P: 1062-1064
Building inhibitory synapses: exchange factors getting into the act?

Justin R. Fallon
News & Views01 Jan 2000
Nature Neuroscience

Volume: 3, P: 5-6
Assessing transmissibility of SARS-CoV-2 lineage B.1.1.7 in England

Genetic and testing data from England show that the SARS-CoV-2 variant of concern B.1.1.7 has a transmission advantage over other lineages.

Erik Volz
Swapnil Mishra
Neil M. Ferguson
Research25 Mar 2021
Nature

Volume: 593, P: 266-269
New insights into the genetic etiology of Alzheimer’s disease and related dementias

Meta-analysis of genome-wide association studies on Alzheimer’s disease and related dementias identifies new loci and enables generation of a new genetic risk score associated with the risk of future Alzheimer’s disease and dementia.

Céline Bellenguez
Fahri Küçükali
Jean-Charles Lambert
ResearchOpen Access04 Apr 2022
Nature Genetics

Volume: 54, P: 412-436
Calcium channels put synapses in their place

Synapse density and patterning must be tightly regulated to ensure proper circuit formation and function. A new report finds that postsynaptic L-type calcium channels control the pattern and differentiation of developing synapses.

Justin R Fallon
News & Views26 Apr 2011
Nature Neuroscience

Volume: 14, P: 536-538
Genomic epidemiology of SARS-CoV-2 in a UK university identifies dynamics of transmission

In this study, Aggarwal and colleagues perform prospective sequencing of SARS-CoV-2 isolates derived from asymptomatic student screening and symptomatic testing of students and staff at the University of Cambridge. They identify important factors that contributed to within university transmission and onward spread into the wider community.

Dinesh Aggarwal
Ben Warne
Ian G. Goodfellow
ResearchOpen Access08 Feb 2022
Nature Communications

Volume: 13, P: 1-16
SARS-CoV-2 evolution during treatment of chronic infection

Chronic infection with SARS-CoV-2 leads to the emergence of viral variants that show reduced susceptibility to neutralizing antibodies in an immunosuppressed individual treated with convalescent plasma.

Steven A. Kemp
Dami A. Collier
Ravindra K. Gupta
Research05 Feb 2021
Nature

Volume: 592, P: 277-282
Genomic assessment of quarantine measures to prevent SARS-CoV-2 importation and transmission

Post-international travel quarantine has been widely implemented to mitigate SARS-CoV-2 transmission, but the impacts of such policies are unclear. Here, the authors used linked genomic and contact tracing data to assess the impacts of a 14-day quarantine on return to England in summer 2020.

Dinesh Aggarwal
Andrew J. Page
Ewan M. Harrison
ResearchOpen Access23 Feb 2022
Nature Communications

Volume: 13, P: 1-13
Genomic reconstruction of the SARS-CoV-2 epidemic in England

A study of the evolution of the SARS-CoV-2 virus in England between September 2020 and June 2021 finds that interventions capable of containing previous variants were insufficient to stop the more transmissible Alpha and Delta variants.

Harald S. Vöhringer
Theo Sanderson
Moritz Gerstung
ResearchOpen Access14 Oct 2021
Nature

Volume: 600, P: 506-511
Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies

Sera from vaccinated individuals and some monoclonal antibodies show a modest reduction in neutralizing activity against the B.1.1.7 variant of SARS-CoV-2; but the E484K substitution leads to a considerable loss of neutralizing activity.

Dami A. Collier
Anna De Marco
Ravindra K. Gupta
Research11 Mar 2021
Nature

Volume: 593, P: 136-141
SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway

The Omicron variant evades vaccine-induced neutralization but also fails to form syncytia, shows reduced replication in human lung cells and preferentially uses a TMPRSS2-independent cell entry pathway, which may contribute to enhanced replication in cells of the upper airway. Altered fusion and cell entry characteristics are linked to distinct regions of the Omicron spike protein.

Brian J. Willett
Joe Grove
Emma C. Thomson
ResearchOpen Access07 Jul 2022
Nature Microbiology

Volume: 7, P: 1161-1179
Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease

Openshaw and colleagues find myeloid inflammation and complement activation signatures in patients with long COVID who were previously hospitalized.

Felicity Liew
Claudia Efstathiou
J. Eunice Zhang
ResearchOpen Access08 Apr 2024
Nature Immunology

Volume: 25, P: 607-621
Best practices for benchmarking germline small-variant calls in human genomes

A new standard allows the accuracy of variant calls to be assessed and compared across different technologies, variant types and genomic regions.

Peter Krusche
Len Trigg
Justin M. Zook
Research11 Mar 2019
Nature Biotechnology

Volume: 37, P: 555-560
Localization of common deletion regions on 1p and 19q in human gliomas and their association with histological subtype

Justin S Smith
Benjamin Alderete
Robert B Jenkins
Research30 Jul 1999
Oncogene

Volume: 18, P: 4144-4152
Proteomics and machine learning in the prediction and explanation of low pectoralis muscle area

Nicholas A. Enzer
Joe Chiles
Mario E. Ruiz
ResearchOpen Access03 Aug 2024
Scientific Reports

Volume: 14, P: 1-13
Author Correction: Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies

Dami A. Collier
Anna De Marco
Ravindra K. Gupta
Amendments and Corrections21 Jul 2022
Nature

Volume: 608, P: E24
Author Correction: SARS-CoV-2 evolution during treatment of chronic infection

Steven A. Kemp
Dami A. Collier
Ravindra K. Gupta
Amendments and Corrections21 Jul 2022
Nature

Volume: 608, P: E23
Publisher Correction: Genomic reconstruction of the SARS CoV-2 epidemic in England

Harald S. Vöhringer
Theo Sanderson
Moritz Gerstung
Amendments and CorrectionsOpen Access07 Jun 2022
Nature

Volume: 606, P: E18
Publisher Correction: SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway

Brian J. Willett
Joe Grove
Emma C. Thomson
Amendments and CorrectionsOpen Access16 Sept 2022
Nature Microbiology

Volume: 7, P: 1709
COVID-19 due to the B.1.617.2 (Delta) variant compared to B.1.1.7 (Alpha) variant of SARS-CoV-2: a prospective observational cohort study

Kerstin Kläser
Erika Molteni
Emma L. Duncan
ResearchOpen Access28 Jun 2022
Scientific Reports

Volume: 12, P: 1-17
Author Correction: Proteomics and machine learning in the prediction and explanation of low pectoralis muscle area

Nicholas A. Enzer
Joe Chiles
Mario E. Ruiz
Amendments and CorrectionsOpen Access04 Mar 2025
Scientific Reports

Volume: 15, P: 1
Genomic epidemiology of SARS-CoV-2 in a university outbreak setting and implications for public health planning

Sema Nickbakhsh
Joseph Hughes
Alison Smith-Palmer
ResearchOpen Access19 Jul 2022
Scientific Reports

Volume: 12, P: 1-17

Search

Synapses take the rap

Acetylcholine receptor-aggregating factor is similar to molecules concentrated at neuromuscular junctions

Publisher Correction: TDP-43 gains function due to perturbed autoregulation in a Tardbp knock-in mouse model of ALS-FTD

Aggregates of acetylcholinesterase induced by acetylcholine receptor-aggregating factor

Internalization of ionotropic glutamate receptors in response to mGluR activation

A massively parallel reporter assay library to screen short synthetic promoters in mammalian cells

Evidence against tetrapod-wide digit identities and for a limited frame shift in bird wings

Synapses go nucle(ol)ar

TDP-43 gains function due to perturbed autoregulation in a Tardbp knock-in mouse model of ALS-FTD

Dendritic mRNA translation: deciphering the uncoded

Building inhibitory synapses: exchange factors getting into the act?

Assessing transmissibility of SARS-CoV-2 lineage B.1.1.7 in England

New insights into the genetic etiology of Alzheimer’s disease and related dementias

Calcium channels put synapses in their place

Genomic epidemiology of SARS-CoV-2 in a UK university identifies dynamics of transmission

SARS-CoV-2 evolution during treatment of chronic infection

Genomic assessment of quarantine measures to prevent SARS-CoV-2 importation and transmission

Genomic reconstruction of the SARS-CoV-2 epidemic in England

Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies

SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway

Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease

Best practices for benchmarking germline small-variant calls in human genomes

Localization of common deletion regions on 1p and 19q in human gliomas and their association with histological subtype

Proteomics and machine learning in the prediction and explanation of low pectoralis muscle area

Author Correction: Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies

Author Correction: SARS-CoV-2 evolution during treatment of chronic infection

Publisher Correction: Genomic reconstruction of the SARS CoV-2 epidemic in England

Publisher Correction: SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway

COVID-19 due to the B.1.617.2 (Delta) variant compared to B.1.1.7 (Alpha) variant of SARS-CoV-2: a prospective observational cohort study

Author Correction: Proteomics and machine learning in the prediction and explanation of low pectoralis muscle area

Genomic epidemiology of SARS-CoV-2 in a university outbreak setting and implications for public health planning

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