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Pretrained using 335,645 whole-slide images, a foundation model is developed to provide representations for slide- and patient-level tasks. It is capable of performing clinical tasks and generating reports even in data-scarce scenarios, such as rare cancer diagnosis and survival prediction, without requiring further fine-tuning.

XCR1+ type 1 conventional DCs (cDC1s) are crucial to mount anti-tumor immune responses, however their infiltration within tumours is often limited. Here the authors show that cDC1 infiltration could be expanded by intratumoral delivery of mesenchymal stromal cells engineered to express the membrane bound form of FLT3L in combination with poly(I:C) or CXCL9 and CCL5, improving anti-tumor immunity in preclinical models.

Wei et al. perform spatial transcriptomic profiling on synovial tissue biopsy samples from individuals with recent-onset rheumatoid arthritis, finding TGFβ signaling and fibrogenic fibroblast activation drive a treatment-refractory tissue phenotype.

The research explores how ultrasound-based human-machine interfaces generalize across a wide variety of situations and participants. Robustness was achieved, with new users able to control virtual hands without the need for calibration.

A single-cell epigenomic atlas of human immune cells highlights cell-type-specific features associated with genetic or environmental exposures.

In statistical physics, systems usually become disordered at high temperatures, but some exhibit entropic order when heated, where one type of ordering enables greater fluctuations in another. Here the authors show how this type of order can persist to arbitrarily high temperature in simple classical and quantum many-body models.

The authors report an integrated triply-resonant superconducting electro-optic transducer combining a 107 GHz NbTiN resonator with a thin-film lithium niobate optical racetrack at telecom wavelengths. Achieving η_OE ≈ 0.82 × 10⁻⁶ and g₀/2π ≈ 0.7 kHz, this work analyzes mm-wave resonator design challenges and proposes strategies for improved quantum transduction.

Tree buds integrate cold and warm cues to control dormancy release. Extended warm periods block plasmodesmata opening by repressing Flowering Locus T and GA pathways in buds. This mechanism ensures robust temporal regulation of dormancy release.

Distinct neuron subtypes compartmentalize specific functions by differentially localizing and translating specific RNAs. This work identifies dynamic subtype- and stage-specific growth cone molecular machinery during neocortical circuit development.

Prenatal Zika virus (ZIKV) exposure can lead to a spectrum of developmental issues, but the mechanisms remain unclear. Here the authors show that prenatal ZIKV exposure in macaques disrupts neurodevelopment, causing prolonged maternal attachment and visual deficits at 3 months that normalize by 12 months, independent of sensory function.

Electrochemical conversion of CO₂ and nitrite offers a green route to produce urea. Here, the authors report co-sputtered copper cobalt catalysts enable efficient C–N coupling through a tandem mechanism, yielding 61 mmol h^⁻1gcat^⁻1 urea at –1.2 V vs. RHE.

Systematic screening of transcription factors reveals conserved mechanisms governing cortical radial glia lineage progression across primates and provides a framework for functional dissection of gene regulatory networks in human cortical neurogenesis.

Vibrio cholerae O1 outbreak strains are classified as Ogawa or Inaba serotypes, but the impact of serotype on pathogenicity is understudied. Here, the authors show that O1 antigen methylation in Ogawa strains promotes colonization and infectivity.

2D p-type transistors are essential for the realization of complementary circuits for post-silicon electronics. Here, the authors report a chloroform doping strategy to fabricate p-type monolayer WSe₂ transistors with high performance and long-term stability.

Metabolite signatures were identified for subtypes of dietary carbohydrate, including added sugar, whole grain and refined grain, and showed different associations with type 2 diabetes, providing an objective measure of dietary risk.

Climate change is altering how plants balance carbon gain and water loss. This study maps global leaf-level water-use efficiency over the past two decades, showing it is highest in regions that are cold or dry, increasing worldwide, and strongly influenced by atmospheric dryness.

Analyzing HPV prevalence among 1,524 women in Gabon, the authors show that most cervical abnormalities in Gabonese women are linked to vaccine-preventable HPV types, supporting the introduction of Gardasil-9 ® and strengthened HPV screening to reduce cervical cancer in Gabon.

A highly chemoselective and enantioselective cross-electrophile coupling using ‘ene’-reductases is reported, and photoexcited enzymes demonstrate the ability to carry out reactions between electrophiles that are not known for small-molecule catalysis.

Nickel(II) dihalide precatalysts with bidentate nitrogen ligands are widely used in cross-coupling reactions, notably in combination with photosensitizers, forming catalytic systems that currently drive major conceptual and synthetic thrusts within organic chemistry. Here the authors show a general mechanism by which these precatalysts are converted to the reduced, catalytically active species, using a range of characterization and spectroscopic techniques.

Hi-C methods for studying 3D genome structure typically require millions of cells and struggle with repetitive regions. Here, authors develop CiFi, combining 3C with PacBio HiFi sequencing, enabling chromatin analysis from as few as 60,000 cells and chromosome-scale assembly from small samples.

Machine-learning-augmented single-nucleus transcriptomic analysis compared molecular landscapes of immature neurons in the mammalian hippocampus across species, highlighting human-specific gene expression but convergent biological processes.

Geometrical frustration in confined systems can lead to the emergence of topological defects, which significantly influence the physical properties of materials. This study demonstrates that grain boundary scars in dense assemblies of active spinners can decouple edge flows from the bulk, resulting in spontaneous self-shearing and a chiral activity-mediated reentrant melting transition.

Flicker noise limits the performance of electronics. Here, the authors demonstrate in nanowires of charge-density wave materials (TaSe₄)₂I and NbS₃ that low-frequency electronic noise is suppressed below the limit of thermalized charge carriers in passive resistors.

The authors use femtosecond-timed Coulomb explosion to study in real time the bimolecular reaction of a single lithium ion diffusing toward a benzene dimer inside a liquid helium nanodroplet until formation of an ion-molecule complex.

Brain-wide recordings in mice reveal that prior expectations are distributed through recurrent loops across all levels of cortical and subcortical processing.

The pathogenic bacterium Pseudomonas aeruginosa can be found in vacuoles and cytoplasm within infected cells. Here, Schator et al. show that extracellular bacteria use a type-III secretion system to induce Ca²⁺ influx into host cells and promote vacuole escape of intracellular bacteria and in vivo dissemination.

High-pressure measurements of the electrical conductivity of (Mg,Fe)O, used as an analogue for basal magma ocean material, indicate that the conductivity is high enough to produce a dynamo much stronger than a core-driven dynamo for super-Earths larger than 3–6 Earth masses.

The 4D Nucleome Project demonstrates the use of genomic assays and computational methods to measure genome folding and then predict genomic structure from DNA sequence, facilitating the discovery of potential effects of genetic variants, including variants associated with disease, on genome structure and function.

There is a growing body of research on disease clusters in multimorbidity, necessitating a systematic review and meta-analysis of methods and findings. Here, the authors show the range of methods applied, and identify six disease clusters with moderate stability across the multimorbidity literature.

Spatially variable surface-elevation changes across 40 global deltas using interferometric synthetic aperture radar are reported.

The primary challenge in commercializing perovskite solar cells stems from the fragile and moisture-sensitive nature of perovskite materials. Here, authors propose a multi-functional asynchronous cross-linking strategy and achieve high-performance and stable devices with mere 0.30 voltage deficit.

Lipid nanoparticle based mRNA vaccines are known to induce robust CD4 + T cell responses. Here the authors establish a role of endogenously derived antigen processing in the optimal priming of CD4 + T cell responses to mRNA lipid nanoparticle vaccines.

A suite of TadA-derived cytosine base editors was optimized to improve efficiency, reduce sequence bias, expand PAM compatibility and minimize artefacts, enabling precise genetic interrogation of variants of uncertain significance (VUS) in zebrafish.

Human challenge studies with SARS-CoV-2 have shown changes in the innate and adaptive immune response. Here the authors are examining potential correlates of infection in virus challenged recipients by assessing baseline immune parameters and how this predicts virus control.

Understanding the mechanisms underlying the survival of drug tolerant persister cells following chemotherapy remains elusive. Here, multi-omics analysis and experimental approaches show that the germ-cell-specific H3K4 methyltransferase PRDM9 promotes metabolic rewiring in glioblastoma stem cells.

Genomic and transcriptomic analysis of samples from patients with multiple myeloma, followed by in vitro validation, indicate mechanisms of antigen escape in response to GPRC5D T cell-engager talquetamab, including biallelic deletions, small nucleotide variants, insertion-deletions and chromatin silencing.

A systematic review including 574 studies extracts information about transmissibility, epidemiological delays and outbreaks for Zika virus disease at global scale.

Although autoantibodies occur in healthy individuals, pathogenic autoantibodies are the key etiologic agent in many autoimmune diseases in humans, most notably lupus erythematosus. In this Review the authors explore how these autoantibodies become pathogenic, what accounts for their specificity, how they cause disease and whether they have a clinical role as biomarkers of disease.

This research developed and compared firearm-specific and method-agnostic machine-learning models using data from 800,579 Army veterans, revealing that model choice and intervention thresholds impact predictive accuracy and fairness, guiding tailored suicide prevention efforts.

Structural characterization of two influenza hemagglutinin stem antibodies reveals binding to non-competing epitopes and the evolution of antigenicity of the hemagglutinin stem, which is a target for developing broadly protective influenza vaccines.

Here, the authors characterise Acinetobacter baumanii and Klebsiella pneumoniae isolated from a single human lung infection and proceed to define their interactions to shed light on how this impacts their evolution, growth parameters, metabolism and antimicrobial responses.

Disease course and pathology an infection may cause can change owing to the structural and functional physiological changes that accumulate with age, but therapy can be tailored accordingly; disease tolerance genes show antagonistic pleiotropy.

Authors report drug repurposing screens against O-GlcNAc cycling enzymes, finding kinase inhibitors that act as splicing modulators to disrupt O-GlcNAc homeostasis and downregulate OGT and OGA. These findings reveal splicing modulator chemotypes and approaches to disrupt O-GlcNAc homeostasis.

Here the authors show that endogenous or therapeutically delivered GDF-15 activates brainstem neurons that trigger splenic β-adrenergic signaling. This, in turn, suppresses autoreactive T cells and reduces neuroinflammation, identifying a possible target for multiple sclerosis treatment.

Chikungunya virus (CHIKV) infects humans and causes chronic arthritic diseases, yet information on CHIKV immune epitopes is still lacking. Here the authors stimulate peripheral blood cells from CHIKV patients with a peptide pool covering the full CHIKV proteome to define CD4 + T cell epitopes as well as to map cross-reactivity with closely related alphaviruses.

Cross-linkable co-SAMs improve hole-selective SAM stability, preventing defects and thermal degredation in perovskite solar cells, enabling 26.92% efficiency with high heat durability, and guiding the design of more efficient and durable solar cells.