Nature Search

TP53 mutations emerge with HDM2 inhibitor SAR405838 treatment in de-differentiated liposarcoma

Pre-clinical studies have shown that TP53 mutations can account for acquired resistance to HDM2 antagonists. This study provides clinical evidence for the emergence of TP53mutations in circulating cell-free DNA, seen in 5 out of 20 de-differentiated liposarcoma patients treated with an HDM2 antagonist.

Joonil Jung
Joon Sang Lee
James Watters
ResearchOpen Access31 Aug 2016
Nature Communications

Volume: 7, P: 1-7
Cryo-EM structure of a type IV secretion system

Cryo-electron microscopy structures of a 2.8 megadalton bacterial type IV secretion system encoded by the plasmid R388 and comprising 92 polypeptides provide insights into the stepwise mechanism of pilus assembly.

Kévin Macé
Abhinav K. Vadakkepat
Gabriel Waksman
ResearchOpen Access22 Jun 2022
Nature

Volume: 607, P: 191-196
Mechanism of effector capture and delivery by the type IV secretion system from Legionella pneumophila

A membrane-embedded complex (called T4CC) is essential for injection of Legionella pneumophila effector proteins into human macrophages via a Type IV secretion system. Here, the authors purify and study the T4CC using functional and cryo-EM structural analyses, providing insights into the secretion mechanisms.

Amit Meir
Kevin Macé
Gabriel Waksman
ResearchOpen Access08 Jun 2020
Nature Communications

Volume: 11, P: 1-11
CNV-association meta-analysis in 191,161 European adults reveals new loci associated with anthropometric traits

Individual SNPs have small effects on anthropometric traits, yet the impact of CNVs has remained largely unknown. Here, Kutalik and co-workers perform a large-scale genome-wide meta-analysis of structural variation and find rare CNVs associated with height, weight and BMI with large effect sizes.

Aurélien Macé
Marcus A. Tuke
Zoltán Kutalik
ResearchOpen Access29 Sept 2017
Nature Communications

Volume: 8, P: 1-11
Targeting neuronal and glial cell types with synthetic promoter AAVs in mice, non-human primates and humans

Targeting genes to specific cell types is valuable for basic science and gene therapy. The authors describe a collection of AAVs containing synthetic promoters targeting a broad range of neuronal cell types in mice, non-human primates and humans.

Josephine Jüttner
Arnold Szabo
Botond Roska
Research08 Jul 2019
Nature Neuroscience

Volume: 22, P: 1345-1356
1216 Growth of Infants Fed with Nan is in Good Agreement with the Who Growth Standard: A Meta-Analysis

D Grathwohl
K Macé
P Steenhout
Research01 Nov 2010
Pediatric Research

Volume: 68, P: 602
1215 Evaluation of Breastfed Infants with Respect to Who Growth Standard: A Meta-Analysis

D Grathwohl
K Macé
P Steenhout
Research01 Nov 2010
Pediatric Research

Volume: 68, P: 602
Cochlear shape distinguishes southern African early hominin taxa with unique auditory ecologies

J. Braga
C. Samir
F. E. Grine
ResearchOpen Access23 Aug 2021
Scientific Reports

Volume: 11, P: 1-10
Reconstitution of telomerase activity combined with HPV-E7 expression allow human preadipocytes to preserve their differentiation capacity after immortalization

C Darimont
I Zbinden
K Macé
Research22 Aug 2003
Cell Death & Differentiation

Volume: 10, P: 1025-1031
Quorum quenching quandary: resistance to antivirulence compounds

Toshinari Maeda
Rodolfo García-Contreras
Thomas K Wood
Research15 Sept 2011
The ISME Journal

Volume: 6, P: 493-501
Time course and dynamics of adipose tissue development in obese and lean Zucker rat pups

E Pouteau
S Turner
K Macé
Research18 Dec 2007
International Journal of Obesity

Volume: 32, P: 648-657
Contribution of mesothelial cells in the expression of inflammatory-related factors in omental adipose tissue of obese subjects

C Darimont
O Avanti
K Macé
Research17 Jul 2007
International Journal of Obesity

Volume: 32, P: 112-120
Dietary fat and fat types as early determinants of childhood obesity: a reappraisal

K Macé
Y Shahkhalili
S Stan
Research28 Nov 2006
International Journal of Obesity

Volume: 30, P: S50-S57
16p11.2 Locus modulates response to satiety before the onset of obesity

A M Maillard
L Hippolyte
S Jacquemont
Research01 Dec 2015
International Journal of Obesity

Volume: 40, P: 870-876

Search

TP53 mutations emerge with HDM2 inhibitor SAR405838 treatment in de-differentiated liposarcoma

Cryo-EM structure of a type IV secretion system

Mechanism of effector capture and delivery by the type IV secretion system from Legionella pneumophila

CNV-association meta-analysis in 191,161 European adults reveals new loci associated with anthropometric traits

Targeting neuronal and glial cell types with synthetic promoter AAVs in mice, non-human primates and humans

1216 Growth of Infants Fed with Nan is in Good Agreement with the Who Growth Standard: A Meta-Analysis

1215 Evaluation of Breastfed Infants with Respect to Who Growth Standard: A Meta-Analysis

Cochlear shape distinguishes southern African early hominin taxa with unique auditory ecologies

Reconstitution of telomerase activity combined with HPV-E7 expression allow human preadipocytes to preserve their differentiation capacity after immortalization

Quorum quenching quandary: resistance to antivirulence compounds

Time course and dynamics of adipose tissue development in obese and lean Zucker rat pups

Contribution of mesothelial cells in the expression of inflammatory-related factors in omental adipose tissue of obese subjects

Dietary fat and fat types as early determinants of childhood obesity: a reappraisal

16p11.2 Locus modulates response to satiety before the onset of obesity

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